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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Functional genomic of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism.

Authors: Costa, Lucio G; Cole, Toby B; Jarvik, Gail P; Furlong, Clement E

Published In Annu Rev Med, (2003)

Abstract: This review focuses on the functional genomics of the human paraoxonase (PON1) polymorphisms. Levels and genetic variability of the PON1 position 192 isoforms (Gln/Arg) influence sensitivity to specific insecticides or nerve agents and risk for cardiovascular disease. A more recent area of investigation, the role of PON1 in drug metabolism, is also discussed. We emphasize the importance of considering both PON1 isoforms and PON1 levels in disease/sensitivity association studies.

PubMed ID: 12525679 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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