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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: A free radical scavenger (Lazaroid U75412E) attenuates tumor necrosis factor-alpha generation in a rabbit model of smoke-induced lung injury.

Authors: Wang, S; Lantz, R C; Rider, E D; Chen, G J; Breceda, V; Hays, A M; Robledo, R F; Tollinger, B J; Dinesh, S V; Witten, M L

Published In Respiration, (1997)

Abstract: The lazaroid (21-aminosteroid) analogue U75412E was evaluated in rabbits exposed to diesel fuel-polycarbonate plastic smoke. Inhalation of total of 4.6 mg U75412E aerosolized at a rate of 1.53 mg/min for 3 min before or after smoke significantly prevented or limited the extent of alveolar hypoventilation, interstitial edema, and tumor necrosis factor-alpha (TNF-alpha) by pulmonary alveolar macrophages (PAM) ex vivo observed at 2 h. The smoke-induced changes in wet lung/body weight ratios and the production of superoxide (O2-) by PAM ex vivo were also attenuated by the drug treatment after smoke exposure (p < 0.05). This study suggests that lazaroids may ameliorate the oxygen-radical-initiated cytokine processes and inflammation cascade as a result of the smoke insult.

PubMed ID: 9311052 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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