Title: Tissue specificity of spontaneous point mutations in lambda supF transgenic mice.

Authors: Leach, E G; Narayanan, L; Havre, P A; Gunther, E J; Yeasky, T M; Glazer, P M

Published In Environ Mol Mutagen, (1996)

Abstract: Transgenic mice carrying multiple copies of a recoverable lambda phage shuttle vector carrying the supF mutation reporter gene (lambda supF) were constructed for the purpose of studying mutagenesis in a whole animal. Spontaneous mutations in rescued supF target genes from mouse liver and skin were analyzed. The mutation frequency was similar in both tissues (in the range of 2 x 10(-5)), but the spectrum of point mutations was distinct, with transitions common in the skin and transversions more prominent in the liver (P = 0.01). These results may help to elucidate pathways of endogenous mutagenesis in vivo, and they illustrate potentially important tissue-specific differences in genetic instability.

PubMed ID: 8991078

MeSH Terms: No MeSH terms associated with this publication