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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Dietary vitamin E does not inhibit the promotion of liver carcinogenesis by polychlorinated biphenyls in rats.

Authors: Glauert, Howard P; Lu, Zijing; Kumar, Amita; Bunaciu, R Petruta; Patel, Sandip; Tharappel, Job C; Stemm, Divinia N; Lehmler, Hans-Joachim; Lee, Eun Y; Robertson, Larry W; Spear, Brett T

Published In J Nutr, (2005 Feb)

Abstract: In this study, the effect of dietary vitamin E on the hepatic tumor-promoting activity of PCB-77 and PCB-153 in female Sprague-Dawley rats (175-200 g) was investigated. One week after diethylnitrosamine injection, rats were fed purified diets containing 10, 50, or 250 mg/kg vitamin E in the form of alpha-tocopheryl acetate. Starting 1 wk later, we injected rats i.p. with vehicle (corn oil) or PCB-77 or PCB-153 (300 mumol/kg) every 14 d for 4 injections. All rats were killed 10 d after the last PCB injection. The number and volume of placental glutathione S-transferase (PGST)-positive foci were increased by PCB-77 but not by PCB-153. Vitamin E did not affect the induction of PGST-positive foci. PCB-77, but not PCB-153, increased hepatic NF-kappaB activity. In conclusion, dietary vitamin E supplementation does not protect against the induction of altered hepatic focal lesions by PCBs.

PubMed ID: 15671227 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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