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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Shock stress protects mice against amphetamine-induced dopaminergic toxicity.

Authors: Carlson, Kirsten M; Wagner, George C

Published In Brain Res, (2006 May 4)

Abstract: The effect of tail shock (ten, 2.0 mA/0.15 s shocks) on amphetamine-induced dopaminergic toxicity in adult, male BALB/c mice was assessed. Fifteen minutes following a single shock session, mice received amphetamine (50-mg/kg) or saline as follows: Shock/Saline; NoShock/Saline; Shock/Amphetamine; No Shock/Amphetamine. Amphetamine caused a 60% dopamine depletion in the No Shock/Amphetamine group. Tail shock provided neuroprotection against amphetamine-induced dopamine depletion, an effect likely related to the stress response.

PubMed ID: 16626635 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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