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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: p53-dependent response in UV-induced transformation.

Authors: Zhang, W; Zhang, X; Zhu, H; Chen, S

Published In Carcinogenesis, (1997 Dec)

Abstract: Cells carrying different numbers of copies of wild-type p53 were transformed by UV irradiation. Putative dense foci were analyzed for their growth behavior in low serum and for anchorage-independence. A correlation was found between number of copies of wild-type p53 gene and transformation frequency: cells with more copies of p53 gene were more resistant to transformation by UV. The p53 in the transformed clones was shown to be wild-type at the protein level. A single DNA base change was detected between GenBank data and our normal and transformed cells; this pre-existing single base difference is probably due to the differences between the strains of mice from which the cells were derived.

PubMed ID: 9450476 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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