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National Institute of Environmental Health Sciences

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Publication Detail

Title: Oxidative metabolism of lipoamino acids and vanilloids by lipoxygenases and cyclooxygenases.

Authors: Prusakiewicz, Jeffery J; Turman, Melissa V; Vila, Andrew; Ball, Heather L; Al-Mestarihi, Ahmad H; Di Marzo, Vincenzo; Marnett, Lawrence J

Published In Arch Biochem Biophys, (2007 Aug 15)

Abstract: The lipoamino acids and endovanilloids have multiple roles in nociception, pain, and inflammation, yet their biological reactivity has not been fully characterized. Cyclooxygenases (COXs) and lipoxygenases (LOs) oxygenate polyunsaturated fatty acids to generate signaling molecules. The ability of COXs and LOs to oxygenate arachidonyl-derived lipoamino acids and vanilloids was investigated. COX-1 and COX-2 were able to minimally metabolize many of these species. However, the lipoamino acids were efficiently oxygenated by 12S- and 15S-LOs. The kinetics and products of oxygenation by LOs were characterized. Whereas 15S-LOs retained positional specificity of oxygenation with these novel substrates, platelet-type 12S-LO acted as a 12/15-LO. Fatty acid oxygenases may play an important role in the metabolic inactivation of lipoamino acids or vanilloids or may convert them to bioactive derivatives.

PubMed ID: 17493578 Exiting the NIEHS site

MeSH Terms: Amino Acids/metabolism*; Animals; Cyclooxygenase 1/metabolism*; Cyclooxygenase 2/metabolism*; Humans; Lipoxygenase/metabolism*; Oxidation-Reduction; Oxygen/metabolism*; Rabbits

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