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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Assembling the pieces.

Authors: Thiele, Dennis J; Gitlin, Jonathan D

Published In Nat Chem Biol, (2008 Mar)

Abstract: Transition metals function as cofactors in specific proteins, catalyzing electron exchange reactions, binding substrates and stabilizing protein structure. Studies of human diseases and of model organisms have defined many of the molecular details of metal uptake, trafficking, and excretion. The current challenge is to integrate these details into a systematic view of metal content, speciation, localization and use within organisms and ecosystems.

PubMed ID: 18277968 Exiting the NIEHS site

MeSH Terms: Animals; Arabidopsis/growth & development; Arabidopsis/metabolism; Catalysis; Cell Membrane/chemistry; Cell Membrane/genetics; Cell Membrane/metabolism; Computational Biology*/trends; Humans; Menkes Kinky Hair Syndrome/genetics; Metalloproteins*/chemistry; Metalloproteins*/genetics; Metalloproteins*/metabolism; Mice; Mice, Knockout; Models, Biological; Systems Biology/trends; Tomography/instrumentation; Tomography/trends; Transition Elements*/chemistry; Transition Elements*/metabolism; Zebrafish

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