Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document
Use this QR code to view the newest version of this document

Your Environment. Your Health.

Publication Detail

Title: Developmental regulation of PV-1 in rat lung: association with the nuclear envelope and limited colocalization with Cav-1.

Authors: Hnasko, Robert; Ben-Jonathan, Nira

Published In Am J Physiol Lung Cell Mol Physiol, (2005 Feb)

Abstract: Plasmalemma vesicle protein-1 (PV-1) is a caveolae-associated protein that is enriched in lung endothelial cells. The PV-1 protein is first detected in the lung at embryonic day 12, before that of caveolin-1 (Cav-1). There is a postnatal rise in PV-1 and Cav-1 mRNA levels, reaching a peak at the time of weaning and declining to their lowest levels in the adult lung. In contrast, the PV-1 protein progressively increases during postnatal development with its highest levels in the adult lung; the Cav-1 protein remains relatively constant throughout this period. Alveolar endothelial cells express both PV-1 and Cav-1 proteins, but PV-1, unlike Cav-1, is also detectable in some bronchial epithelial cells. Endothelial cells transfected with a rat PV-1 construct show a punctate membrane distribution of PV-1, perinuclear accumulation, and an association with the nuclear envelope. In these cells, PV-1 exhibits only partial perinuclear colocalization with Cav-1 and F-actin. In summary, PV-1 is developmentally regulated in the rat lung and shows a divergent intracellular localization, with a limited caveolae/Cav-1 colocalization in cultured endothelial cells.

PubMed ID: 15640522 Exiting the NIEHS site

MeSH Terms: Aging/metabolism*; Animals; Animals, Newborn/growth & development; Animals, Newborn/metabolism; Carrier Proteins/genetics; Carrier Proteins/metabolism*; Cattle; Caveolin 1; Caveolins/genetics; Caveolins/metabolism*; Cells, Cultured; Embryo, Mammalian/metabolism; Embryonic Development; Endothelial Cells/metabolism; Endothelium, Vascular/embryology; Lung/embryology*; Lung/growth & development; Lung/metabolism*; Membrane Proteins/genetics; Membrane Proteins/metabolism*; Nuclear Envelope/metabolism*; Pulmonary Alveoli/blood supply; Pulmonary Alveoli/embryology; RNA, Messenger/metabolism; Rats; Rats, Sprague-Dawley; Tissue Distribution; Transfection

Back
to Top