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National Institute of Environmental Health Sciences

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Publication Detail

Title: Disruption of endothelial barrier function: relationship to fluidity of membrane extracellular lamella.

Authors: Alvarado, A; Butterfield, D A; Hennig, B

Published In Int J Biochem, (1994 Apr)

Abstract: 1. Endothelial cells were cultured in tissue culture flasks or on microcarrier beads and labeled with a lipid specific spin-label. 2. Exposure of endothelial cells to benzyl alcohol caused a dose- and time-dependent increase in membrane fluidity using electron spin resonance (ESR). Maximum fluidity was reached after a 5-min exposure to 100 mM benzyl alcohol. 3. Albumin permeability across endothelial cells cultured on micropore filters was used as an indication of endothelial monolayer integrity. 4. A significant increase in permeability occurred with 50 mM benzyl alcohol. Maximal albumin permeability was reached after a 5-min exposure to 100 mM benzyl alcohol.

PubMed ID: 8013743 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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