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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Delayed reproductive death as a dominant phenotype in cell clones surviving X-irradiation.

Authors: Chang, W P; Little, J B

Published In Carcinogenesis, (1992 Jun)

Abstract: Residual damage manifested as reduced cloning efficiency was observed in many of the cloned progeny of Chinese hamster ovary (CHO) cells and human carcinoma SQ-20B cells surviving X-irradiation. This stable phenotype, which we have termed delayed reproductive death, persisted for greater than 50 generations of cell replication post-irradiation. Clones showing this phenotype were aneuploid, and formed colonies with a high proportion of giant cells. By somatic cell hybridization of CHO clones, the delayed reproductive death phenotype was found to be a dominant trait; the cloning efficiency of hybrid clones was persistently depressed, as compared with that of control hybrid cells. These results suggest that delayed reproductive death represents a specific cellular response that may persist in some of the progeny of mammalian cells for long periods after X-irradiation.

PubMed ID: 1600612 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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