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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Lack of evidence for perfluorodecanoyl- or perfluorooctanoyl-coenzyme A formation in male and female rats.

Authors: Kuslikis, B I; Vanden Heuvel, J P; Peterson, R E

Published In J Biochem Toxicol, (1992)

Abstract: Perfluorodecanoic (PFDA) and perfluorooctanoic (PFOA) acids belong to the structurally diverse group of compounds known to cause peroxisomal proliferation. It has been hypothesized that the common mode of action of these compounds is that they act through an activated coenzyme A (CoA) thioester. Using rat liver microsomal and isolated rat hepatocyte incubation conditions that were effective in producing a CoA conjugate of clofibric acid, no corresponding CoA derivative could be found for either PFDA or PFOA.

PubMed ID: 1588571 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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