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Publication Detail

Title: Inositol trisphosphate and thapsigargin discriminate endoplasmic reticulum stores of calcium in rat brain.

Authors: Verma, A; Hirsch, D J; Hanley, M R; Thastrup, O; Christensen, S B; Snyder, S H

Published In Biochem Biophys Res Commun, (1990 Oct 30)

Abstract: ATP dependent Ca2+ accumulation into oxalate-loaded rat brain microsomes is potently inhibited by thapsigargin with an IC50 of 2 nM and maximal inhibition at 10 nM. Approximately 15% of the total A23187-releasable microsomal calcium store is insensitive to thapsigargin concentrations up to 100 microM. Inositol-1,4,5-trisphosphate (IP3) maximally inhibits 40% of the net Ca2+ accumulation by whole brain microsomes. Its effects are non-additive with thapsigargin suggesting that the IP3-sensitive Ca2+ pool is a subset of the thapsigargin sensitive Ca2+ pool. Marked regional differences occur in Ca2+ transport rates and sensitivity to both thapsigargin and IP3.

PubMed ID: 2241971 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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