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National Institute of Environmental Health Sciences

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Publication Detail

Title: Regional and subcellular distribution of cytochrome P-450-dependent drug metabolism in monkey brain: the olfactory bulb and the mitochondrial fraction have high levels of activity.

Authors: Iscan, M; Reuhl, K; Weiss, B; Maines, M D

Published In Biochem Biophys Res Commun, (1990 Jun 29)

Abstract: In brain of female monkey (M. fascicularis) the content of cytochrome P-450 and benzo(a)pyrene hydroxylase activity in the mitochondrial fraction exceeded that of the microsomes by more than 4-fold. The mitochondrial drug metabolism activity exhibited substrate specificity and, unlike the microsomes, did not catalyze 7-ethoxyresorufin O-deethylase reaction. Moreover, the rate of benzo(a)pyrene hydroxylase activity by both the mitochondrial and the microsomal fractions displayed regional variation with the olfactory bulb displaying the highest hydroxylase activity. In contrast, the microsomal 7-ethoxyresorufin O-deethylase activity was uniformally distributed in all brain regions.

PubMed ID: 2363728 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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