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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Efficient immortalization by SV40 T DNA of skin fibroblasts from patients with Wilms' tumor associated with chromosome 11p deletion.

Authors: Kano, Y; Little, J B

Published In Mol Carcinog, (1989)

Abstract: We report that transfection with a plasmid containing the SV40 early region (T) leads to a very high frequency of immortalization in two different strains of human diploid fibroblasts, each with a partial deletion of the short arm of chromosome 11. Immortalization often occurred without a recognizable "crisis" phase. Preimmortal cells showed a high frequency of spontaneous mutations and chromosomal aberrations. These results suggest that a gene involved in the control of senescence of human cells in vitro may be associated with this chromosome.

PubMed ID: 2559742 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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