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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Differential response of human and rodent cell lines to chemical inhibition of the repair of potentially lethal damage.

Authors: Little, J B; Ueno, A M; Dahlberg, W K

Published In Radiat Environ Biophys, (1989)

Abstract: We have examined the effects of several classes of metabolic inhibitors on the repair of potentially lethal damage in density-inhibited cultures of two rodent and two human cell systems which differ in their growth characteristics. Aphidicolin, 1-beta-D-arabinofuranosylcytosine (ara-C) and hydroxyurea showed no effect on PLD repair, whereas the effects of 9-beta-D-arabinofuranosyladenine (ara-A) and 3-aminobenzamide (3-AB) were cell line dependent. For example, 3-AB suppressed PLD repair almost completely in CHO cells, but showed no inhibitory effects in human diploid fibroblasts. These results indicate that inhibitors of DNA replication and poly(ADP-ribose) synthesis are not efficient inhibitors of cellular recovery in irradiated cells and, moreover, that such effects may be cell line dependent.

PubMed ID: 2508186 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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