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Publication Detail

Title: Modification of radiosensitivity and recovery from X ray damage in vitro by retinoic acid.

Authors: Rutz, H P; Little, J B

Published In Int J Radiat Oncol Biol Phys, (1989 May)

Abstract: We studied the effects of all-trans retinoic acid (RA) combined with X-irradiation on confluent cultures of human breast cancer (MCF-7) and melanoma (C-143) cell lines, as well as in a normal human diploid fibroblast strain (AG 1522). RA in non-cytotoxic concentrations was a potent inhibitor of confluent holding recovery of potentially lethal damage (PLD repair) for all three cell types. A complete inhibition of recovery was observed at lower RA concentrations in the tumor lines than in the fibroblast strain. Exposure to RA prior to and during irradiation resulted in a radiosensitizing effect that was similar in MCF-7 and AG 1522 cells. The implications of these findings are discussed in terms of the potential value of retinoids as biological response modifiers for the clinical radiotherapy of cancer.

PubMed ID: 2715081 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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