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Who We Fund: Basic Cellular And Molecular Research - Genome Integrity

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Viewing 71 results
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Title Principal Investigator Institution Grant Number RFA PA Number Program Officer Pubs Primary Science Code Secondary Science Code
2023-2025 ANNUAL MEETINGS OF THE ENVIRONMENTAL MUTAGENESIS AND GENOMICS SOCIETY (EMGS) bemis, jeffrey c Environmental Mutagenesis/Genomics Soc R13ES036022 PA21-151 Shaughnessy, Daniel 0 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
ACCURATE AND COST-EFFECTIVE DETECTION OF MUTAGENICITY AND MUTAGENIC EXPOSURE sharifi, sam Mutagentech, Inc. R43ES036101 PA22-176 Shaughnessy, Daniel 0 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
APE1 CLEAVAGE MECHANISMS DURING DNA REPAIR freudenthal, bret d University Of Kansas Medical Center R01ES029203 PA16-160 Heacock, Michelle 13 09 - Genome Integrity -
APPLICATIONS OF THE LONG-TERM CULTURE HUMAN PRIMORDIAL GERM CELL-LIKE CELLS TO TOXICOLOGICAL ASSESSMENTS AND MECHANISTIC STUDIES ON CHEMICALLY CAUSED HERITABLE HUMAN HEALTH THREATS shioda, toshihiro Massachusetts General Hospital R21ES034468 PA20-195 Shaughnessy, Daniel 3 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
APPLYING GENOMIC DOSIMETERS OF UV DAMAGE TO PREDICTING SKIN CANCER RISK brash, douglas e Yale University R01ES030562 PAR18-704 Shaughnessy, Daniel 5 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
ATM ACTIVATION BY DNA SINGLE-STRAND BREAKS yan, shan University Of North Carolina Charlotte R21ES032966 PA20-195 Heacock, Michelle 9 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
CHEMICAL BIOLOGY OF DNA AND RNA ALKYLATION wang, yinsheng University Of California Riverside R35ES031707 ES19-007 Tyson, Frederick 41 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
COLLABORATIVE FUNCTIONS OF BRCA2 AND RAD51 PARALOGS IN HOMOLOGOUS RECOMBINATION jensen, ryan brown Yale University R21ES034164 PA20-195 Shaughnessy, Daniel 0 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
CROSS-LINKS AT ABASIC SITES IN DUPLEX DNA gates, kent s University Of Missouri-Columbia R01ES021007 PA18-484 Shaughnessy, Daniel 30 09 - Genome Integrity -
DEFINING THE MOLECULAR BASIS OF ONCOGENE-INDUCED REPLICATION STRESS huang, tony tung New York University School Of Medicine R01ES031658 PA19-056 Shaughnessy, Daniel 7 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
DNA ADDUCT DETECTION AND REPAIR IN MAMMALIAN CELLS sancar, aziz Univ Of North Carolina Chapel Hill R01ES033414 PAR19-251 Shaughnessy, Daniel 18 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
DNA ADDUCT-INDUCED MUTAGENESIS stone, michael p Vanderbilt University R01ES029357 PA16-160 Shaughnessy, Daniel 20 09 - Genome Integrity -
DNA ADDUCTOME OF HUMAN BLADDER FROM THE TOBACCO EXPOSOME turesky, robert j. University Of Minnesota R01ES030559 PAR18-704 Shaughnessy, Daniel 4 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
DNA PROTEIN CROSS-LINKS:CELLULAR EFFECTS AND REPAIR MECHANISMS tretyakova, natalia y University Of Minnesota R01ES023350 PA18-484 Shaughnessy, Daniel 41 09 - Genome Integrity -
DNA REPAIR PATHWAY COORDINATION DURING DAMAGE PROCESSING schaich, matthew allen University Of Pittsburgh At Pittsburgh F32ES034982 PA21-048 Shaughnessy, Daniel 0 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
DNA–PROTEIN CROSS-LINKING SEQUENCING FOR GENOME-WIDE MAPPING OF ABASIC SITES AT SINGLE-NUCLEOTIDE RESOLUTION tang, feng University Of California Riverside K99ES035446 PA20-188 Shaughnessy, Daniel 0 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
ENVIRONMENTAL DNA LESIONS AND MUTAGENESIS: MOLECULAR MECHANISMS OF LESION RECOGNITION FOR REPAIR AND POLYMERASE BYPASS broyde, suse New York University R01ES025987 PA20-185 Heacock, Michelle 26 09 - Genome Integrity -
ENVIRONMENTAL FACTORS AND COMPOUNDS AFFECTING THE GENOMIC STABILITY IN HAPLOINSUFFICIENT BRCA1 CELLS. gerhardt, jeannine Weill Medical Coll Of Cornell Univ R01ES034733 PA20-185 Shaughnessy, Daniel 1 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
ERROR-SUPPRESSED WHOLE GENOME SEQUENCING FOR GENOTOXICANT-INDUCED STRUCTURAL VARIANT DETECTION wilson, thomas edward University Of Michigan At Ann Arbor R21ES034143 PA20-195 Shaughnessy, Daniel 0 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
FUNCTIONS OF SRAP DOMAIN PROTEINS IN DNA METABOLISM cortez, david k Vanderbilt University R01ES030575 PA18-484 Shaughnessy, Daniel 9 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
GENOTOXIC STRESS RESPONSE AND MUTAGENESIS IN NORMAL TISSUES OF MICE DEFICIENT IN HOMOLOGY DIRECTED REPAIR jackson, james Tulane University Of Louisiana R01ES032036 PA20-185 Shaughnessy, Daniel 4 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
HOW SSB REGULATES YOAA-CHI'S FUNCTION IN DNA DAMAGE REPAIR pollenz, savannah weeks University Of Florida F31ES034652 PA21-051 Shaughnessy, Daniel 1 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
HYPERMUTATION IN BACTERIA AND HUMANS goodman, myron University Of Southern California R35ES028343 ES16-008 Shaughnessy, Daniel 16 09 - Genome Integrity -
IDENTIFYING CHROMATIN FACTORS ESSENTIAL FOR DNA REPAIR USING A NOVEL HIGH-THROUGHPUT SCREENING METHODOLOGY clarke, thomas l Boston University Medical Campus R00ES034443 PA20-188 Shaughnessy, Daniel 0 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
IMPLICATION OF HISTONE H4 LRS MUTATIONS IN TRANSLESION SYNTHESIS AND UV MUTAGENESIS li, shisheng Louisiana State Univ A&M Col Baton Rouge R03ES033789 PA20-200 Reinlib, Leslie 2 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
INDIRECT GENOTOXICITY IN METAL CARCINOGENESIS zhitkovich, anatoly Brown University R01ES031002 PA19-056 Tyson, Frederick 9 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
INTEGRATIVE MODELING OF BIOMOLECULAR MACHINERY IN NUCLEOTIDE EXCISION REPAIR ivanov, ivaylo nikolaev Georgia State University R01ES032786 PA20-185 Shaughnessy, Daniel 2 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
INVESTIGATING ENVIRONMENTAL RISK FACTORS FOR BREAST CANCER USING ADDUCTOMICS funk, william e Northwestern University At Chicago R01ES031809 PAR19-251 Shaughnessy, Daniel 0 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
INVESTIGATING ROLES FOR OXIDATIVE GUANINE DAMAGE IN TRANSCRIPTION REGULATION de rosa, mariarosaria University Of Pittsburgh At Pittsburgh K99ES035871 PA20-188 Heacock, Michelle 0 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
INVESTIGATING THE CELLULAR IMPACT OF 8-OXO-GUANINE ON DNA REPLICATION AND GENOME STABILITY barnes, ryan p University Of Kansas Medical Center R00ES033771 PA20-188 Heacock, Michelle 0 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
INVESTIGATION OF HUMAN DNA POLYMERASE EPSILON VARIANTS pursell, zachary f Tulane University Of Louisiana R01ES028271 PA20-185 Shaughnessy, Daniel 11 09 - Genome Integrity -
KIDNEY DNA ADDUCTOMICS turesky, robert j. University Of Minnesota R01ES030765 PA19-056 Shaughnessy, Daniel 3 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
MEASURING GENOMIC DNA DAMAGE AND DNA REPAIR CAPACITY IN LONGITUDINAL POPULATION SAMPLES - A STEP TOWARDS PRECISION PREVENTION sobol, robert w Brown University U01ES029518 ES17-006 Boyles, Abee 18 09 - Genome Integrity -
MEASURING NUCLEOTIDE EXCISION REPAIR IN HUMAN POPULATIONS niedernhofer, laura jane University Of Minnesota U01ES029603 ES17-006 Heacock, Michelle 8 09 - Genome Integrity -
MECHANISM OF EUKARYOTIC ENVIRONMENTAL MUTAGENESIS walker, graham c Massachusetts Institute Of Technology R35ES028303 ES16-008 Shaughnessy, Daniel 11 09 - Genome Integrity -
MECHANISM OF RAD51C FORK PROTECTION AND ENVIRONMENTAL CARCINOGENESIS schlacher, katharina University Of Tx Md Anderson Can Ctr R01ES029680 PA16-160 Shaughnessy, Daniel 8 09 - Genome Integrity -
MECHANISMS OF DNA DOUBLE-STRAND BREAK END RESECTION AND REPAIR PATHWAY CHOICE sung, patrick University Of Texas Hlth Science Center R01ES007061 PA20-185 Mcallister, Kimberly 139 09 - Genome Integrity -
MECHANISMS OF REPLICATION FORK DEGRADATION IN VERTEBRATES dewar, james m Vanderbilt University R01ES034847 PA20-185 Shaughnessy, Daniel 1 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
MOLECULAR ARCHITECTURE OF OXIDATIVE STRESS INDUCED DOUBLE STRAND BREAK REPAIR jamsen, joonas Univ Of Arkansas For Med Scis R00ES029572 PA16-193 Heacock, Michelle 0 09 - Genome Integrity -
MOLECULAR STRUCTURE OF CHROMIUM-DNA ADDUCTS vincent, john bertram University Of Alabama In Tuscaloosa R15ES033800 PAR18-714 Shaughnessy, Daniel 3 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
MULTI-PATHWAY DNA REPAIR CAPACITY MEASUREMENTS IN LUNG CANCER PATIENTS AND HEALTHY CONTROLS nagel, zachary david Harvard School Of Public Health U01ES029520 ES17-006 Shaughnessy, Daniel 11 09 - Genome Integrity -
MUTATIONAL PROFILING IN HUMAN CELLS AS AN IN VITRO ALTERNATIVE TO IN VIVO MUTAGENICITY ASSESSMENTS recio, leslie Scitovation, Llc R44ES035336 PA22-176 Shaughnessy, Daniel 0 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
NGS-BASED ANALYSIS OF MUTATION SIGNATURES DURING THE TRANSLESION SYNTHESIS sugiyama, tomohiko Ohio University Athens R15ES029723 PAR18-714 Shaughnessy, Daniel 2 09 - Genome Integrity -
NICKEL AND TOXIC TOPOISOMERASE I PRODUCTS zhitkovich, anatoly Brown University R01ES031979 PA20-185 Tyson, Frederick 8 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
NOVEL MARKERS OF EXPOSURE AND PATHWAYS OF RESPONSE TO CHROMIUM lemos, bernardo University Of Arizona R01ES027981 PA21-268 Shaughnessy, Daniel 13 09 - Genome Integrity -
ONCOMETABOLITES, DNA REPAIR, AND CANCER glazer, peter m Yale University R01ES005775 PA20-185 Shaughnessy, Daniel 83 09 - Genome Integrity -
R-LOOPS AT THE TELOMERE AS A TOXIC SOURCE OF GENOMIC INSTABILITY griffith, jack d Univ Of North Carolina Chapel Hill R01ES031635 PA19-056 Heacock, Michelle 14 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
RAD51 PARALOG FUNCTION IN CANCER PREDISPOSITION AND GENOME INTEGRITY bernstein, kara a University Of Pennsylvania R01ES031796 PA20-185 Shaughnessy, Daniel 9 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
REGULATION OF DNA EXCISION REPAIR IN CHROMATIN wyrick, john j Washington State University R01ES028698 PA16-160 Shaughnessy, Daniel 30 09 - Genome Integrity -
REGULATION OF P53 AND CHECKPOINT SIGNALING BY CHROMIUM(VI) zhitkovich, anatoly Brown University R01ES028072 PA16-160 Tyson, Frederick 14 09 - Genome Integrity -
REGULATION OF THE DNA DAMAGE RESPONSE cimprich, karlene a Stanford University R01ES016486 PA16-160 Shaughnessy, Daniel 32 09 - Genome Integrity 01 - Basic Cellular or Molecular processes
REPAIR OF ENVIRONMENTALLY INDUCED MITOCHONDRIAL DNA DAMAGE prakash, aishwarya University Of South Alabama R01ES030084 ES18-001 Shaughnessy, Daniel 8 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
REPAIR OF OXIDATIVE DAMAGE IN G-QUADRUPLEX PROMOTER DNA whitaker, amy michelle Research Inst Of Fox Chase Can Ctr R00ES031148 PA19-130 Heacock, Michelle 2 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
REPLICATION FORK DYNAMICS AND REPAIR BY RAD51 PARALOGUES AFTER DNA ALKYLATION bernstein, kara a University Of Pennsylvania R01ES030335 PA18-484 Shaughnessy, Daniel 14 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
REPLICATION-COUPLED REPAIR: A MECHANISM FOR SURVIVING UV IRRADIATION courcelle, justin Portland State University R21ES034880 PA20-195 Shaughnessy, Daniel 4 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
ROLE OF AFLATOXIN-INDUCED DNA DAMAGE FORMATION AND REPAIR IN HEPATIC MUTAGENESIS li, wentao University Of Georgia R00ES030015 PA18-398 Cui, Yuxia 4 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
ROLE OF BASE EXCISION REPAIR IN LIMITING HEPATOCELLULAR CARCINOMAS lloyd, r. stephen Oregon Health & Science University R01ES031086 PA19-056 Heacock, Michelle 8 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
SHU COMPLEX AND RAD52 FUNCTION IN DNA DAMAGE RECOGNITION AND SUBSEQUENT REPAIR hengel, sarah r Tufts University Medford R00ES033738 PA20-188 Shaughnessy, Daniel 2 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
STRUCTURAL BASIS OF EUKARYOTIC CLAMP LOADING remus, dirk Sloan-Kettering Inst Can Research R01ES036297 PA20-185 Shaughnessy, Daniel 0 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
STUDIES OF CHEMICALLY LABILE ALKYLATION DAMAGE IN DNA lee, seongmin University Of Texas At Austin R01ES034781 PA20-185 Shaughnessy, Daniel 1 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
TELOMERE DYSFUNCTION DRIVEN MOLECULAR OUTPUTS IN THE CARDIAC UNIT gurkar, aditi u University Of Pittsburgh At Pittsburgh R01ES035733 ES22-007 Heacock, Michelle 0 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
TELOMERE UNCAPPING EPIGENETICALLY REPROGRAMS A STRESS RESPONSE AND LONGEVITY PATHWAY ahmed, shawn cameron Univ Of North Carolina Chapel Hill R01ES035777 ES22-007 Heacock, Michelle 0 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
THE MUTAGENIC CONSEQUENCES OF REPLICATION-COUPLED DNA REPAIR MECHANISMS mehta, kavi University Of Wisconsin-Madison R00ES034058 PA20-188 Shaughnessy, Daniel 0 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
THE ROLE OF AQUAPORIN 3 IN ARSENIC-INDUCED DNA DAMAGE AND MUTAGENESIS xia, jun Creighton University R00ES033259 PA20-188 Shaughnessy, Daniel 5 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
THE ROLE OF CENP-A IN THE RESPONSE TO DNA DOUBLE-STRAND BREAKS kitagawa, katsumi University Of Texas Hlth Science Center R21ES033354 PA20-195 Shaughnessy, Daniel 0 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
THE ROLE OF MONO-ADP-RIBOSYLATION BY PARP14 IN RADIORESISTANCE moldovan, george lucian Pennsylvania State Univ Hershey Med Ctr R01ES026184 PA20-185 Shaughnessy, Daniel 26 09 - Genome Integrity -
TRANSLESION SYNTHESIS DNA POLYMERASES AND GENOME INSTABILITY shcherbakova, polina v University Of Nebraska Medical Center R01ES015869 PA18-484 Heacock, Michelle 23 09 - Genome Integrity 01 - Basic Cellular or Molecular processes
UNDERSTANDING POST TRANSLATIONAL MODIFIERS IN DNA DAMAGE REPAIR dray, eloise University Of Texas Hlth Science Center R21ES035997 PA20-195 Heacock, Michelle 0 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
URINARY DNA ADDUCTOMICS FOR THE ASSESSMENT OF EXPOSURE TO CANCER RISK FACTORS cooke, marcus stanley University Of South Florida R01ES030557 PAR18-704 Shaughnessy, Daniel 10 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
WATCHING COOPERATIVE INTERACTIONS BETWEEN BASE AND NUCLEOTIDE EXCISION REPAIR PROTEINS van houten, bennett University Of Pittsburgh At Pittsburgh R35ES031638 ES19-007 Heacock, Michelle 23 09 - Genome Integrity 03 - Carcinogenesis/Cell Transformation
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