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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Person Details: Richard A. Corley

Superfund Research Program

Richard A. Corley

Pacific Northwest National Laboratory
Biological Monitoring and Modeling Group
P.O. Box 999
MSIN: P7-59
Richland, Washington 99352
Phone: 509-371-6983
Fax: 509-371-6978
Email: rick.corley@pnnl.gov

Projects

Publications

2022

  • Pande P, Madeen E, Williams DE, Crowell SR, Ognibene T, Turteltaub KW, Corley RA, Smith JN. 2022. Translating dosimetry of Dibenzo[def,p]chrysene (DBC) and metabolites across dose and species using physiologically based pharmacokinetic (PBPK) modeling. Toxicol Appl Pharmacol 438:doi:10.1016/j.taap.2021.115830 PMID:34933053 PMCID:PMC9264404

2021

  • Stoddard EG, Nag S, Martin J, Tyrrell KJ, Gibbins T, Anderson KA, Shukla AK, Corley RA, Wright AT, Smith JN. 2021. Exposure to an environmental mixture of polycyclic aromatic hydrocarbons induces hepatic cytochrome P450 enzymes in mice. Chem Res Toxicol 34(9):2145-2156. doi:10.1021/acs.chemrestox.1c00235 PMID:34472326

2019

  • Madeen E, Siddens LK, Uesugi S, McQuistan TJ, Corley RA, Smith JN, Waters KM, Tilton SC, Anderson KA, Ognibene T, Turteltaub KW, Williams DE. 2019. Toxicokinetics of benzo[a]pyrene in humans: Extensive metabolism as determined by UPLC-accelerator mass spectrometry following oral micro-dosing. Toxicol Appl Pharmacol 364:97-105. doi:10.1016/j.taap.2018.12.010 PMID:30582946 PMCID:PMC6369707
  • Stoddard EG, Nag S, Martin J, Killinger BJ, Corley RA, Smith JN, Wright AT. 2019. Benzo[a]pyrene induction of glutathione S-transferases: an activity-based protein profiling investigation. Chem Res Toxicol 32(6):1259-1267. doi:10.1021/acs.chemrestox.9b00069 PMID:30938511

2018

  • Sadler NC, Webb-Robertson B, Clauss TR, Pounds J, Corley RA, Wright AT. 2018. High-fat diets alter the modulatory efects of xenobiotics on cytochrome P450 activities. Chem Res Toxicol 31:308-318. doi:10.1021/acs.chemrestox.8b00008 PMID:29688711

2017

  • Shrivastava M, Lou S, Zelenyuk A, Easter RC, Corley RA, Thrall BD, Rasch PJ, Fast JD, Simonich SL, Shen H, Tao S. 2017. Global long-range transport and lung cancer risk from polycyclic aromatic hydrocarbons shielded by coatings of organic aerosol. Proc Natl Acad Sci U S A 114(6):1246-1251. doi:10.1073/pnas.1618475114 PMID:28115713 PMCID:PMC5307436
  • Smith JN, Mehinagic D, Nag S, Crowell SR, Corley RA. 2017. In vitro metabolism of benzo[a]pyrene-7,8-dihydrodiol and dibenzo[def,p]chrysene-11,12 diol in rodent and human hepatic microsomes. Toxicol Lett 269:23-32. doi:10.1016/j.toxlet.2017.01.008 PMID:28119020

2016

  • Madeen E, Ognibene T, Corley RA, Henderson MC, Baird WM, Bench G, Turteltaub KW, Williams DE, McQuistan TJ. 2016. Human microdosing with carcinogenic polycyclic aromatic hydrocarbons: in vivo pharmacokinetics of dibenzo[def,p]chrysene and metabolites by UPLC accelerator mass spectrometry. Chem Res Toxicol 29(10):1641-1650. doi:10.1021/acs.chemrestox.6b00169 PMID:27494294 PMCID:PMC5380438
  • Sadler NC, Nandhikonda P, Webb-Robertson B, Ansong C, Anderson LN, Smith JN, Corley RA, Wright AT. 2016. Hepatic cytochrome P450 activity, abundance, and expression throughout human development. Drug Metab Dispos 44(7):984-991. doi:10.1124/dmd.115.068593 PMID:27084891 PMCID:PMC4931891
  • Teeguarden J, Tan Y, Edwards SW, Leonard JA, Anderson KA, Corley RA, Harding A, Kile ML, Simonich SL, Stone D, Tanguay RL, Waters KM, Harper SL, Williams DE. 2016. Expanding on successful concepts, models, and organization. Environ Sci Technol 50(17):8921-8922. doi:10.1021/acs.est.6b03027 PMID:27509267
  • Teeguarden J, Tan Y, Edwards SW, Leonard JA, Anderson KA, Corley RA, Kile ML, Simonich SL, Stone D, Tanguay RL, Waters KM, Harper SL, Williams DE. 2016. Completing the link between exposure science and toxicology for improved environmental health decision making: the aggregate exposure pathway framework. Environ Sci Technol 50(9):4579-4586. doi:10.1021/acs.est.5b05311 PMID:26759916 PMCID:PMC4854780

2015

  • Madeen E, Corley RA, Crowell SR, Turteltaub KW, Ognibene T, Malfatti MA, McQuistan TJ, Garrard M, Sudakin D, Williams DE. 2015. Human in vivo pharmacokinetics of [(14)C]dibenzo[def,p]chrysene by accelerator mass spectrometry following oral microdosing. Chem Res Toxicol 28(1):126-134. doi:10.1021/tx5003996 PMID:25418912 PMCID:PMC4303324

2013

2012

  • Shorey LE, Castro DJ, Baird WM, Siddens LK, Lohr CV, Matzke MM, Waters KM, Corley RA, Williams DE. 2012. Transplacental carcinogenesis with dibenzo[def,p]chrysene (DBC): Timing of maternal exposures determines target tissue response in offspring. Cancer Lett 317(1):49-55. doi:10.1016/j.canlet.2011.11.010 PMID:22085489 PMCID:PMC3269513

2011

  • Crowell SR, Amin S, Anderson KA, Krishnegowda G, Sharma AK, Soelberg JJ, Williams DE, Corley RA. 2011. Preliminary physiologically based pharmacokinetic models for benzo a pyrene and dibenzo def,p chrysene in rodents. Toxicol Appl Pharmacol 257:365-376. doi:10.1016/j.taap.2011.09.020 PMID:22001385 PMCID:PMC3226888
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