Superfund Research Program
Sangeeta N. Bhatia
University of California-San Diego
Department of Bioengineering
9500 Gilman Drive, 0412
La Jolla, California 92093-0412
Email: sbhatia@bioeng.ucsd.edu
Projects
- University of California-San Diego: Microscale Engineered Liver Tissue for Toxicant Testing (2005-2010)
Publications
2004
- Khetani SR, Szulgit G, Del Rio JA, Barlow C, Bhatia SN. 2004. Exploring interactions between rat hepatocytes and nonparenchymal cells using gene expression profiling. Hepatology 40(3):545-554. doi:10.1002/hep.20351 PMID:15349892
- Lin P, Chan WC, Badylak S, Bhatia SN. 2004. Assessing porcine liver-derived biomatrix for hepatic tissue engineering. Tissue Engineering Part A 10(7-8):1046-53. PMID:15363162
2003
- Allen JW, Bhatia SN. 2003. Formation of steady-state oxygen gradients in vitro: application to liver zonation. Biotechnol Bioeng 82(3):253-262. doi:10.1002/bit.10569 PMID:12599251
- Gopalan SM, Flaim C, Bhatia SN, Hoshijima M, Knoell R, Chien KR, Omens JH, McCulloch AD. 2003. Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomers. Biotechnol Bioeng 81(5):578-587. PMID:12514807
- Li YY, Cunin F, Link JR, Gao T, Betts RE, Reiver SH, Chin V, Bhatia SN, Sailor MJ. 2003. Polymer replicas of photonic porous silicon for sensing and drug delivery applications. Science 299(5615):2045-2047. PMID:12663921
- Ozkan M, Pisanic T, Scheel J, Barlow C, Esener S, Bhatia SN. 2003. Electro-optical platform for the manipulation of live cells. Langmuir 19(5):1532-1538.
- Vozzi G, Flaim C, Ahluwalia A, Bhatia SN. 2003. Fabrication of PLGA scaffolds using soft lithography and microsyringe deposition. Biomaterials 24(14):2533-2540. PMID:12695080
2002
- Cunin F, Schmedake T, Link JR, Li YY, Koh J, Bhatia SN, Sailor MJ. 2002. Biomolecular screening with encoded porous-silicon photonic crystals. Nat Mater 1(1):39-41. doi:10.1038/nmat702 PMID:12618846
- Liu VA, Bhatia SN. 2002. Three-dimensional photopatterning of hydrogels containing living cells. Biomed Microdevices 4(4):257-66.
- Liu VA, Jastromb WE, Bhatia SN. 2002. Engineering protein and cell adhesivity using PEO-terminated triblock polymers. J Biomed Mater Res 60(1):126-134. doi:10.1002/jbm.10005 PMID:11835168
2001
- Allen JW, Hassanein T, Bhatia SN. 2001. Advances in bioartificial liver devices. Hepatology 34(3):447-455. PMID:11526528
- Chin V, Collins BE, Sailor MJ, Bhatia SN. 2001. Compatibility of primary hepatocytes on nanoporous silicon. Advanced Materials 13(24):1877-1880.
2000
- Behnia K, Bhatia SN, Jastromb N, Balis U, Sullivan S, Yarmush M, Toner M. 2000. Xenobiotic metabolism by cultured primary porcine hepatocytes. Tissue Engineering Part A 6(5):467-479. PMID:11074934
1999
- Balis U, Behnia K, Dwarakanath B, Bhatia SN, Sullivan S, Yarmush M, Toner M. 1999. Oxygen consumption characteristics of porcine hepatocytes. Metab Eng 1(1):49-62. PMID:10935754
- Bhatia SN, Balis U, Yarmush M, Toner M. 1999. Effect of cell-cell interactions in preservation of cellular phenotype: co-cultivation of hepatocytes and non-parenchymal cells. FASEB J 13(14):1883-1900. PMID:10544172
- Bhatia SN, Chen CS. 1999. Tissue engineering at the micro-scale. Biomed Microdevices 2(2):131-144.
- Ledezma GA, Folch A, Bhatia SN, Balis U, Yarmush M, Toner M. 1999. Numerical model of fluid flow and oxygen transport in a radial-flow microchannel containing hepatocytes. J Biomech Eng 121(1):58-64. PMID:10080090
1998
- Bhatia SN, Balis U, Yarmush M, Toner M. 1998. Microfabrication of hepatocyte/fibroblast co-cultures: role of homotypic cell interactions. Biotechnol Prog 14(3):378-387. PMID:9622518
- Bhatia SN, Balis U, Yarmush M, Toner M. 1998. Probing heterotypic cell interactions: hepatocyte function in microfabricated co-cultures. Journal of Biomaterials Science, Polymer Edition 9(11):1137-1160. PMID:9860177
1997
- Bhatia SN, Yarmush M, Toner M. 1997. Controling cell interactions by micropatterning in co-cultures: hepatocytes and 3T3 fibroblasts. J Biomed Mater Res 34(2):189-199. PMID:9029299
1996
- Bhatia SN, Toner M, Foy BD, Rotem A, Tompkins R, Yarmush M. 1996. Zonal liver cell heterogeneity: effects of oxygen on metabolic functions of hepatocytes. Journal of Cellular Engineering 1:125-135.