Superfund Research Program

Dr Guy A. Perkins

University of California-San Diego
Department of Neurosciences
La Jolla, California 92093

Projects

• University of California-San Diego: Multiscale Imaging and Proteomics Core (2005-2017)

Publications

2016

• Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins GA, Ali S, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M. 2016. NF-κB restricts inflammasome activation via elimination of damaged mitochondria. Cell 164(5):896-910. doi:10.1016/j.cell.2015.12.057 PMID:26919428 PMCID:PMC4769378

2014

• Dowding JM, Song W, Bossy K, Karakoti A, Kumar A, Kim AH, Bossy B, Seal S, Ellisman MH, Perkins GA, Self WT, Bossy-Wetzel E. 2014. Cerium oxide nanoparticles protect against A beta -induced mitochondrial fragmentation and neuronal cell death. Cell Death Differ 21(10):1622-1632. doi:10.1038/cdd.2014.72 PMID:24902900 PMCID:PMC4158687

2012

• Lee J, Budanov AV, Talukdar S, Park E, Park H, Park H, Bandyopadhyay G, Li N, Aghajan M, Jang I, Wolfe AM, Perkins GA, Ellisman MH, Bier E, Scadeng M, Foretz M, Viollet B, Olefsky J, Karin M. 2012. Maintenance of metabolic homeostasis by Sestrin 2 and Sestrin 3. Cell Metab 16(3):311-321. doi:10.1016/j.cmet.2012.08.004 PMID:22958918 PMCID:PMC3687365
• Perkins GA, Scott RT, Perez A, Ellisman MH, Johnson JE, Fox DA. 2012. Bcl-xL-mediated remodeling of rod and cone synaptic mitochondria after postnatal lead exposure: Electron microscopy, tomography and oxygen consumption. Mol Vis 18:3029-3048. PMID:23288995 PMCID:PMC3534145

2010

• Lee J, Budanov AV, Park E, Birse R, Kim TE, Perkins GA, Ocorr K, Ellisman MH, Bodmer R, Bier E, Karin M. 2010. Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science 327(5970):1223-1228. doi:10.1126/science.1182228 PMID:20203043 PMCID:PMC2866632
• Suhr ST, Chang E, Tjong J, Alcasid N, Perkins GA, Goissis M, Ellisman MH, Perez GI, Cibelli J. 2010. Mitochondrial rejuvenation after induced pluripotency. PLoS One 5:e14095:doi:10.1371/journal.pone.0014095 PMID:21124794 PMCID:PMC2991355

2009

• Perkins GA, Bossy-Wetzel E, Ellisman MH. 2009. New insights into mitochondrial structure during cell death. Experimental Neurology 218(2):183-92. doi:10.1016/j.expneurol.2009.05.021 PMID:19464290 PMCID:PMC2712651
• Perkins GA, Sun M, Frey TG. 2009. Chapter 2 Correlated light and electron microscopy/electron tomography of mitochondria in situ. Methods Enzymol 456:29-52. doi:10.1016/S0076-6879(08)04402-9 PMID:19348881 PMCID:PMC2730195
• Yamaguchi R, Perkins GA. 2009. Dynamics of mitochondrial structure during apoptosis and the enigma of Opa1. Biochim Biophys Acta 1787(8):963-972. doi:10.1016/j.bbabio.2009.02.005 PMID:19245786 PMCID:PMC2773558

2008

• Knott AB, Perkins GA, Schwarzenbacher R, Bossy-Wetzel E. 2008. Mitochondrial fragmentation in neurodegeneration. Nat Rev Neurosci 9(7):505-518. doi:10.1038/nrn2417 PMID:18568013 PMCID:PMC2711514
• Yamaguchi R, Lartigue L, Perkins GA, Scott RT, Dixit A, Kushnareva Y, Kuwana T, Ellisman MH, Newmeyer DD. 2008. Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization. Mol Cell 31(4):557-569. doi:10.1016/j.molcel.2008.07.010 PMID:18691924 PMCID:PMC2636708

2003

• He L, Perkins GA, Poblenz AT, Harris JB, Hung M, Ellisman MH, Fox DA. 2003. Bcl-xL overexpression blocks bax-mediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead-exposed mice. Proc Natl Acad Sci U S A 100(3):1022-1027. doi:10.1073/pnas.0333594100 PMID:12540825 PMCID:PMC298719