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National Institute of Environmental Health Sciences

 

Person Details

Superfund Research Program

James A. Swenberg

University of North Carolina-Chapel Hill
Department of Environmental Sciences and Engineering
253C Rosenau Hall, CB# 7431
Chapel Hill, NC 27599-7431
Phone: 919-966-6139
Fax: 919-966-6123
Email:

Projects

Research Briefs

Patents

  • Method of detecting DNA single strand breaks
  • Methods for Detection of Single Strand Breaks in DNA

Superfund Sites

Ciba-Giegy Corp. Site

  • University of North Carolina-Chapel Hill: Biomarkers of Exposure versus Effect: Improving the Scientific Basis for Risk Assessment

Hudson River PCBs

  • University of North Carolina-Chapel Hill: Biomarkers of Exposure versus Effect: Improving the Scientific Basis for Risk Assessment

Publications

2013
  • Edrissi, Bahar, Koli Taghizadeh, Benjamin C. Moeller, Dean Kracko, Melanie Doyle-Eisele, James A. Swenberg, and Peter C. Dedon. 2013. Dosimetry of n(6)-formyllysine adducts following [(13)c(2)h2]-formaldehyde exposures in rats. Chemical Research in Toxicology.   26(10):1421-1423. doi:10.1021/tx400320u  
  • Moeller, Benjamin C., Leslie Recio, Amanda Green, Wei Sun, Fred A. Wright, Wanda M. Bodnar, and James A. Swenberg. 2013. Biomarkers of exposure and effect in human lymphoblastoid TK6 cells following C-13(2)-acetaldehyde exposure. Toxicological Sciences.   133(1):1-12. doi:10.1093/toxsci/kft029  
  • Rager, Julia E., Benjamin C. Moeller, Melanie Doyle-Eisele, Dean Kracko, James A. Swenberg, and Rebecca C. Fry. 2013. Formaldehyde and epigenetic alterations: MicroRNA changes in the nasal epithelium of nonhuman primates. Environmental Health Perspectives. 121(3):339-344. doi:10.1289/ehp.1205582  
  • Rager, Julia E., Benjamin C. Moeller, Sloane K. Miller, Dean Kracko, Melanie Doyle-Eisele, James A. Swenberg, and Rebecca C. Fry. 2013. Formaldehyde-associated changes in microRNAs: Tissue and temporal specificity in the rat nose, white blood cells, and bone marrow. Toxicological Sciences.   doi:10.1093/toxsci/kft267  
  • Starr, Thomas B. and James A. Swenberg. 2013. A novel bottom-up approach to bounding low-dose human cancer risks from chemical exposures. Regulatory Toxicology and Pharmacology.   65(3):311-315. doi:10.1016/j.yrtph.2013.01.004  
2012
  • Lu, Kun, Sessaly Craft, Jun Nakamura, Benjamin C. Moeller, and James A. Swenberg. 2012. Use of LC-MS/MS and Stable Isotopes to Differentiate Hydroxymethyl and Methyl DNA Adducts from Formaldehyde and Nitrosodimethylamine. Chemical Research in Toxicology.   25(3):664-675. doi:10.1021/tx200426b  
  • Lu, Kun, Husamettin Gul, Patricia B. Upton, Benjamin C. Moeller, and James A. Swenberg. 2012. Formation of Hydroxymethyl DNA Adducts in Rats Orally Exposed to Stable Isotope Labeled Methanol. Toxicological Sciences.   126(1):28-38. doi:10.1093/toxsci/kfr328  
  • Mutlu, Esra, Yo-Chan Jeong, Leonard B. Collins, Amy-Joan L. Ham, Patricia B. Upton, Gary Hatch, Darrell Winsett, Paul Evansky, and James A. Swenberg. 2012. A New LC-MS/MS Method for the Quantification of Endogenous and Vinyl Chloride-Induced 7-(2-Oxoethyl)Guanine in Sprague–Dawley Rats. Chemical Research in Toxicology.   25(2):391-399. doi:10.1021/tx200447w  
  • Nakamura, Jun, Husamettin Gul, Xu Tian, Scott J. Bultman, and James A. Swenberg. 2012. Detection of PIGO-Deficient Cells Using Proaerolysin: A Valuable Tool to Investigate Mechanisms of Mutagenesis in the DT40 Cell System. PLoS ONE.   7(3):e33563. doi:10.1371/journal.pone.0033563  
  • Swenberg, James A., Benjamin C. Moeller, Kun Lu, Julia E. Rager, Rebecca C. Fry, and Thomas B. Starr. 2012. Formaldehyde carcinogenicity research: 30 years and counting for mode of action, epidemiology, and cancer risk assessment. Toxicologic Pathology.   doi:10.1177/0192623312466459  
2011
  • Adami, Hans-Olov, Colin L. Berry, Charles B. Breckenridge, Lewis L. Smith, James A. Swenberg, Dimitrios Trichopoulos, Noel S. Weiss, and Timothy P. Pastoor. 2011. Toxicology and Epidemiology: Improving the Science with a Framework for Combining Toxicological and Epidemiological Evidence to Establish Causal Inference. Toxicological Sciences.   122(2):223-234. doi:10.1093/toxsci/kfr113  
  • Ito, Shinsuke, Li Shen, Qing Dai, Susan C. Wu, Leonard B. Collins, James A. Swenberg, Chuan He, and Yi Zhang. 2011. Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine. Science.   333(6047):1300-1303. doi:10.1126/science.1210597  
  • Jung, Dawoon, Cole W. Matson, Leonard B. Collins, Geoff Laban, Heather M. Stapleton, John W. Bickham, James A. Swenberg, and Richard T. Di Giulio. 2011. Genotoxicity in Atlantic killifish (Fundulus heteroclitus) from a PAH-contaminated Superfund site on the Elizabeth River, Virginia. Ecotoxicology. 20:1890-1899. doi:10.1007/s10646-011-0727-9  
  • Koturbash, Igor, Anne Scherhag, Kenneth Sexton, Wanda M. Bodnar, Volodymyr P. Tryndyak, James A. Swenberg, Frederick A. Beland, Igor P. Pogribny, Ivan Rusyn, and John R. Latendresse. 2011. Epigenetic alterations in liver of C57BL/6J mice after short-term inhalational exposure to 1,3-Butadiene. Environmental Health Perspectives. 119:635-640. doi:10.1289/ehp.1002910  
  • Lu, Kun, Benjamin C. Moeller, Melanie Doyle-Eisele, Jacob D. McDonald, and James A. Swenberg. 2011. Molecular Dosimetry of N2-Hydroxymethyl-dG DNA Adducts in Rats Exposed to Formaldehyde. Chemical Research in Toxicology.   24(2):159-161. doi:10.1021/tx1003886  
  • Luke, A.M., Paul D. Chastain, Brian F. Pachkowski, Valeriy Afonin, Shunichi Takeda, David G. Kaufman, James A. Swenberg, and Jun Nakamura. 2011. Accumulation of true single strand breaks and AP sites in base excision repair deficient cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis.   694:65-71. doi:10.1016/j.mrfmmm.2010.08.008  
  • Moeller, Benjamin C., Kun Lu, Melanie Doyle-Eisele, Jacob D. McDonald, Andrew Gigliotti, and James A. Swenberg. 2011. Determination of N2-Hydroxymethyl-dG Adducts in the Nasal Epithelium and Bone Marrow of Nonhuman Primates Following 13CD2-Formaldehyde Inhalation Exposure. Chemical Research in Toxicology.   24(2):162-164. doi:10.1021/tx1004166  
  • Ridpath, John R., Shunichi Takeda, James A. Swenberg, and Jun Nakamura. 2011. Convenient, multi-well plate-based DNA damage response analysis using DT40 mutants is applicable to a high-throughput genotoxicity assay with characterization of modes of action. Environmental and Molecular Mutagenesis.   52(2):153-160. doi:10.1002/em.20595  
  • Swenberg, James A., Kun Lu, Benjamin C. Moeller, Lina Gao, Patricia B. Upton, Jun Nakamura, and Thomas B. Starr. 2011. Endogenous versus Exogenous DNA Adducts: Their Role in Carcinogenesis, Epidemiology, and Risk Assessment. Toxicological Sciences.   120(suppl1):S130-S145. doi:10.1093/toxsci/kfq371  
  • Wu, Kuen-Yuh, Su-Yin Chiang, Wei-Chung Shih, Chih-Chun J. Huang, Ming-Feng Chen, and James A. Swenberg. 2011. The application of mass spectrometry in molecular dosimetry: Ethylene oxide as an example. Mass Spectrometry Reviews.   30(5):733-756. doi:10.1002/mas.20299  
2010
  • Asagoshi, Kenjiro, Keizo Tano, Paul D. Chastain, N. Adachi, Eiichiro Sonoda, K. Kikuchi, H. Koyama, K. Nagata, David G. Kaufman, Shunichi Takeda, Samuel H. Wilson, Masami Watanabe, James A. Swenberg, and Jun Nakamura. 2010. FEN1 functions in long patch base excision repair under conditions of oxidative stress in vertebrate cells. Molecular Cancer Research.   8:204-15. doi:10.1158/1541-7786.MCR-09-0253  
  • Boysen, Gunnar, Leonard B. Collins, Shengkai Liao, A.M. Luke, Brian F. Pachkowski, Joanne L. Watters, and James A. Swenberg. 2010. Analysis of 8-oxo-7,8-dihydro-2′-deoxyguanosine by ultra high pressure liquid chromatography–heat assisted electrospray ionization–tandem mass spectrometry. Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences. 878(3-4):375-380. doi:10.1016/j.jchromb.2009.12.004  
  • Chastain, Paul D., Jun Nakamura, S. Rao, H. Chu, J. Ibrahim, James A. Swenberg, and David G. Kaufman. 2010. Abasic sites preferentially form at regions undergoing DNA replication. FASEB Journal.   24(10):3674-80. doi:10.1096/fj.09-145276  
  • Lu, Kun, Leonard B. Collins, Hongyu Ru, Edilberto Bermudez, and James A. Swenberg. 2010. Distribution of DNA adducts caused by inhaled formaldehyde is consistent with induction of nasal carcinoma but not Leukemia. Toxicological Sciences.   116(2):441-451. doi:10.1093/toxsci/kfq061  
  • Lu, Kun, Wenjie Ye, Li Zhou, Leonard B. Collins, Xian Chen, Avram Gold, Louise M. Ball, and James A. Swenberg. 2010. Structural characterization of formaldehyde-induced cross-links between amino acids and deoxynucleosides and their oligomers. Journal of American Chemical Society. 132(10):3388-3399. doi:10.1021/ja908282f  
  • Mutlu, Esra, Leonard B. Collins, Matthew D. Stout, Patricia B. Upton, Laura R. Daye, Darrell Winsett, Gary Hatch, Paul Evansky, and James A. Swenberg. 2010. Development and Application of an LC-MS/MS Method for the Detection of the Vinyl Chloride-Induced DNA Adduct N2,3-Ethenoguanine in Tissues of Adult and Weanling Rats Following Exposure to [13C2]-VC. Chemical Research in Toxicology.   23(9):1485-1491. doi:10.1021/tx1001767  
2009
  • Bordeerat, Narisa K., Nadia I. Georgieva, David G. Klapper, Leonard B. Collins, Tyra J. Cross, Christoph H. Borchers, James A. Swenberg, and Gunnar Boysen. 2009. Accurate quantitation of standard peptides used for quantitative proteomics. Proteomics. 9(15):3939-3944. doi:10.1002/pmic.200900043  
  • Boysen, Gunnar, Brian F. Pachkowski, Jun Nakamura, and James A. Swenberg. 2009. The formation and biological significance of N7-guanine adducts. Mutation Research/Genetic Toxicology and Environmental Mutagenesis.  
  • Jung, Dawoon, Youngeun Cho, Leonard B. Collins, James A. Swenberg, and Richard T. Di Giulio. 2009. Effects of benzo[a]pyrene on mitochondrial and nuclear DNA damage in Atlantic killifish (Fundulus heteroclitus) from a creosote-contaminated and reference site. Aquatic Toxicology.   95(1):44-51. doi:10.1016/j.aquatox.2009.08.003  
  • Kim, Sungkyoon, Gunnar Boysen, James A. Swenberg, Avram Gold, Louise M. Ball, Blair U. Bradford, Ivan Rusyn, and Leonard B. Collins. 2009. Liquid chromatography electrospray ionization tandem mass spectrometry analysis method for simultaneous detection of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine. Toxicology.   262(3):230-238. doi:10.1016/j.tox.2009.06.013  
  • Pachkowski, Brian F., Keizo Tano, Valeriy Afonin, Rhoderick H. Elder, Shunichi Takeda, Masami Watanabe, James A. Swenberg, and Jun Nakamura. 2009. Cells deficient in PARP-1 show an accelerated accumulation of DNA single strand breaks, but not AP sites, over the PARP-1-proficient cells exposed to MMS. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis.   671(1-2):93-99. doi:10.1016/j.mrfmmm.2009.09.006  
  • Swenberg, James A., Thomas B. Starr, Richard Albertini, and Vernon Walker. 2009. Response to Keshava et al. Chemical Research in Toxicology.   22(1):10-12. doi:10.1021/tx800438g  
  • Ye, Wenjie, Avram Gold, Louise M. Ball, James A. Swenberg, and Kun Lu. 2009. Formation of S-[1-(N2-deoxyguanosinyl)methyl]glutathione between glutathione and DNA induced by formaldehyde. Journal of American Chemical Society. 131(10):3414-5. doi:10.1021/ja808048c  
  • Ye, Wenjie, Avram Gold, Louise M. Ball, James A. Swenberg, and Kun Lu. 2009. The formation of S-[1-(N^-deoxyguanosinyl)methyl]-glutathione between glutathione and DNA during the detoxification of formaldehyde. Journal of American Chemical Society. 131(10):3414-3415. doi:10.1021/ja808048c  
2008
  • Brusick, D., M.S. Small, E.L. Cavalieri, D. Chakravarti, X. Ding, D.G. Longfellow, Jun Nakamura, E.C. Rogan, and James A. Swenberg. 2008. Possible genotoxic modes of action for naphthalene. Regulatory Toxicology and Pharmacology.   51:S43-50. doi:10.1016/j.yrtph.2007.12.002  
  • Jeong, Yo-Chan, N.J. Walker, D.E. Burgin, G. Kissling, M. Gupta, Lawrence L. Kupper, Linda S. Birnbaum, and James A. Swenberg. 2008. Accumulation of M1dG DNA adducts after chronic exposure to PCBs, but not from acute exposure to polychlorinated aromatic hydrocarbons. Free Radical Biology and Medicine.   45(5):585-91. doi:10.1016/j.freeradbiomed.2008.04.043  
  • Lu, Kun, Gunnar Boysen, James A. Swenberg, Lina Gao, and Leonard B. Collins. 2008. Formaldehyde-Induced histone modifications in vitro. Chemical Research in Toxicology.   21(8):1586-1593. doi:10.1021/tx8000576  
  • Swenberg, James A., E. Fryar-Tita, Yo-Chan Jeong, Gunnar Boysen, Thomas B. Starr, Vernon Walker, and Richard Albertini. 2008. Biomarkers in toxicology and risk assessment: informing critical dose-response relationships. Chemical Research in Toxicology.   21(1):253-265.
2007
  • Brusick, D., M.S. Small, E.L. Cavalieri, D. Chakravarti, X. Ding, D.G. Longfellow, Jun Nakamura, E.C. Rogan, and James A. Swenberg. 2007. Possible genotoxic modes of action for naphthalene. Regulatory Toxicology and Pharmacology.  
  • Kupper, Lawrence L., James A. Swenberg, J.L. Waiters, J.A. Satia, and J.C. Schroeder. 2007. Associations of antioxidant nutrients and oxidative DNA damage in healthy African-American and White adults. Cancer Epidemiology Biomarkers & Prevention.   16(7):1428-36.
  • Ridpath, John R., Jun Nakamura, Keizo Tano, A.M. Luke, Eiichiro Sonoda, Hirohumi Arakawa, Jean-Marie Buerstedde, D.A. Gillespie, J.E. Sale, M. Yamazoe, D.K. Bishop, M. Takata, Shunichi Takeda, Masami Watanabe, and James A. Swenberg. 2007. Cells deficient in the FANC/BRCA pathway are hypersensitive to plasma levels of formaldehyde. Cancer Research.   67(23):11117-22.
2006
  • Chastain, Paul D., Jun Nakamura, James A. Swenberg, and David G. Kaufman. 2006. Nonrandom AP site distribution in highly proliferative cells. FASEB Journal.   20(14):2612-4.
  • DeSimone, Michelle C., David Harbourt, Gunnar Boysen, Leonard B. Collins, Blair U. Bradford, Jun Han, James A. Swenberg, David W. Threadgill, and Ivan Rusyn. 2006. Multi-strain study of trichoroethylene toxicity in mice. In: Superfund Basic Research Program Annual Meeting, December 11-12. La Jolla, CA.
  • Pachkowski, Brian F., Scott Winkel, Yoshiko Kubota, James A. Swenberg, Robert C. Millikan, and Jun Nakamura. 2006. XRCC1 genotype and breast cancer: Functional studies and epidemiologic data show interactions between XRCC1 codon 280 his and smoking. Cancer Research.   66(5):2860-2868.
  • Roper, J.Chadwick, Denise M. Brown, Michelle A. Sullivan, Robert Schoonhoven, James A. Swenberg, and Frederic K. Pfaender. 2006. Epifluorescence microscopy and image analysis of high-level polycyclic aromatic hydrocarbon contamination in soils. Environmental Toxicology and Chemistry.   25(12):3093-100.
2005
  • Bammler, Theodor K., Richard P. Beyer, Sanchita Bhattacharya, Gary A. Boorman, Abee Boyles, Blair U. Bradford, Roger E. Bumgarner, Pierre R. Bushel, Kabir Chaturvedi, Dongseok Choi, Michael L. Cunningham, Shibing Deng, Holly K. Dressman, Rickie D. Fannin, Federico M. Farin, Jonathan H. Freedman, Rebecca C. Fry, Angel Harper, Michael C. Humble, Patrick Hurban, Terrance J. Kavanagh, William K. Kaufmann, Kathleen F. Kerr, Li Jing, Jodi A. Lapidus, Michael R. Lasarev, Jianying Li, Yi-Ju Li, Edward K. Lobenhofer, Xinfang Lu, Renae L. Malek, Sean Milton, Srinivasa R. Nagalla, Jean P. O'Malley, Valerie S. Palmer, Patrick Pattee, Richard S. Paules, Charles M. Perou, Ken Phillips, Li-Xuan Qin, Yang Qiu, Sean D. Quigley, Matthew Rodland, Ivan Rusyn, Leona D. Samson, David A. Schwartz, Yan Shi, Jung-Lim Shin, Stella O. Sieber, Susan Slifer, Marcy C. Speer, Peter S. Spencer, Dean I. Sproles, James A. Swenberg, William A. Suk, Robert C. Sullivan, Ru Tian, Raymond W. Tennant, Signe A. Todd, Charles J. Tucker, Bennett Van Houten, Brenda K. Weis, Shirley Xuan, and Helmut F. Zarbl. 2005. Standardizing global gene expression analysis between laboratories and across platforms. Nature Methods. 2(5):351-6.
  • Jeong, Yo-Chan and James A. Swenberg. 2005. Formation of M1G-dR from endogenous and exogenous ROS-inducing chemicals. Free Radical Biology and Medicine.   39(8):1021-1029.
  • Jeong, Yo-Chan, Jun Nakamura, Patricia B. Upton, and James A. Swenberg. 2005. Pyrimido[1,2-a]-purin-10(3H)-one, M1G, is less prone to artifact than base oxidation. Nucleic Acids Research.   33(19):6426-6434.
  • Jeong, Yo-Chan, Ramiah Sangaiah, Jun Nakamura, Brian F. Pachkowski, Asoka Ranasinghe, Avram Gold, Louise M. Ball, and James A. Swenberg. 2005. Analysis of M(1)G-dR in DNA by aldehyde reactive probe labeling and liquid chromatography tandem mass spectrometry. Chemical Research in Toxicology.   18(1):51-60.
  • Lin, Chia-Hua, Hong-Tsee Leow, Shih-Chien Huang, Jun Nakamura, James A. Swenberg, and Po-Hsiung Lin. 2005. Induction of cytotoxicity, aldehydic DNA lesions, and poly(ADP-ribose) polymerase-1 activation by catechol derivatives of pentachlorophenol in calf thymus DNA and in human breast cancer cells. Chemical Research in Toxicology.   18(2):257-264.
  • Weis, Brenda K., David M. Balshaw, J.R. Barr, D. Brown, Mark H. Ellisman, Paul J. Lioy, G. Omenn, J.D. Potter, Martyn T. Smith, Lydia Sohn, William A. Suk, S. Sumner, James A. Swenberg, D.R. Walt, S. Watkins, Claudia L. Thompson, and Samuel H. Wilson. 2005. Personalized exposure assessment: promising approaches for human environmental health research. Environmental Health Perspectives. 113(7):840-8.
2004
  • Ham, Amy-Joan L., Bevin P. Engelward, Hasan Koc, Ramiah Sangaiah, Lisiane B. Meira, Leona D. Samson, and James A. Swenberg. 2004. New immunoaffinity-LC-MS/MS methodology reveals that Aag null mice are deficient in their ability to clear 1,N-6-etheno-deoxyadenosine DNA lesions from lung and liver in vivo. DNA Repair.   3(3):257-265.
  • Hu, Chiung-Wen, Ming-Tsang Wu, Mu-Rong Chao, Chih-Hong Pan, Chien-Jen Wang, James A. Swenberg, and Kuen-Yuh Wu. 2004. Comparison of analyses of urinary 8-hydroxy-2 '-deoxyguanosine by isotope-dilution liquid chromatography with electrospray tandem mass spectrometry and by enzyme-linked immunosorbent assay. Rapid Communications in Mass Spectrometry.   18(4):505-510.
  • Lin, Po-Hsiung, Ramiah Sangaiah, Asoka Ranasinghe, Louise M. Ball, James A. Swenberg, and Avram Gold. 2004. Synthesis of chlorinated and non-chlorinated biphenyl-2,3-and 3,4-catechols and their [H-2(3)]-isotopomers. Organic & Biomolecular Chemistry.   2(18):2624-2629.
  • Rusyn, Ivan, Shoji Asakura, Brian F. Pachkowski, Blair U. Bradford, Mikhail F. Denissenko, Jeffrey M. Peters, Steven M. Holland, Janardan K. Reddy, Michael L. Cunningham, and James A. Swenberg. 2004. Expression of base excision DNA repair genes is a sensitive biomarker for in vivo detection of chemical-induced chronic oxidative stress: Identification of the molecular source of radicals responsible for DNA damage by peroxisome proliferators. Cancer Research.   64(3):1050-1057.
  • Slikker, William, Matthew S. Bogdanffy, James S. Bus, Steven D. Cohen, Rory B. Conolly, Raymond M. David, Nancy G. Doerrer, David C. Dorman, David W. Gaylor, Dale Hattis, John M. Rogers, R. Woodrow Setzer, James A. Swenberg, Kendall Wallace, and Melvin E. Andersen. 2004. Dose-dependent transitions in mechanisms of toxicity. Toxicology and Applied Pharmacology.   201(3):203-225.
  • Swenberg, James A. 2004. Toxicological considerations in the application and interpretation of DNA adducts in epidemiological studies. IARC Scientific Publications. 157:237-246.
  • Zielinska-Park, Joanna, Jun Nakamura, James A. Swenberg, and Michael D. Aitken. 2004. Aldehydic DNA lesions in calf thymus DNA and HeLa S3 cells produced by bacterial quinone metabolites of fluoranthene and pyrene. Carcinogenesis.   25(9):1727-1733.
2003
  • Albertini, Richard, Harvey Clewell, Matthew W. Himmelstein, Eric J. Morinello, Stephen Olin, Julian Preston, Louis Scarano, Martyn T. Smith, James A. Swenberg, Raymond R. Tice, and Curtis Travis. 2003. The use of non-tumor data in cancer risk assessment: reflections on butadiene, vinyl chloride, and benzene. Regulatory Toxicology and Pharmacology.   37(1):105-132.
  • Barbin, Alain, Hiroko Ohgaki, Jun Nakamura, Michael Kurrer, Paul Kleihues, and James A. Swenberg. 2003. Endogenous deoxyribonucleic acid (DNA) damage in human tissues: A comparison of ethenobases with aldehydic DNA lesions. Cancer Epidemiology Biomarkers & Prevention.   12(11):1241-1247.
  • Horton, Julie K., Donna F. Joyce-Gray, Brian F. Pachkowski, James A. Swenberg, and Samuel H. Wilson. 2003. Hypersensitivity of DNA polymerase beta null mouse fibroblasts reflects accumulation of cytotoxic repair intermediates from site-specific alkyl DNA lesions. DNA Repair.   2(1):27-48.
  • Li, Y., Gunnar Boysen, N.D. Dicheva, Patricia B. Upton, and James A. Swenberg. 2003. Effects of Free Unmodified Purine Basis, Guanine and Adenine, on Ionization of Three N-7 Guanine DNA Adducts Using LC/ESI/MS/MS. In: Proceedings of the American Society of Mass Spectrometry, 51st Annual Conference.
  • Lin, Po-Hsiung, Jun Nakamura, Shuji Yamaguchi, Shoji Asakura, and James A. Swenberg. 2003. Aldehydic DNA lesions induced by catechol estrogens in calf thymus DNA. Carcinogenesis.   24(6):1133-1141.
  • Nakamura, Jun and James A. Swenberg. 2003. Aldehyde Reactive Probe-Slot Blot Assay to quantitate DNA lesions caused by oxidative stress. In: Methods in Biological Oxidative Stress. Humana Press, pp.109-115.
  • Nakamura, Jun, Shoji Asakura, Susan D. Hester, Gilbert de Murcia, Keith W. Caldecott, and James A. Swenberg. 2003. Quantitation of intracellular NAD(P)H can monitor an imbalance of DNA single strand break repair in base excision repair deficient cells in real time. Nucleic Acids Research.   31(17):e104.
  • Nakamura, Jun, Elizabeth R. Purvis, and James A. Swenberg. 2003. Micromolar concentrations of hydrogen peroxide induce oxidative DNA lesions more efficiently than millimolar concentrations in mammalian cells. Nucleic Acids Research.   31(6):1790-1795.
  • Pachkowski, Brian F., Jun Nakamura, Y. Li, Ramiah Sangaiah, Avram Gold, and James A. Swenberg. 2003. An LC/MS Approach to the Differentiation of Aldehydic Deoxyribose Lesions. In: Proceedings of the American Association for Cancer Research Annual Meeting, 2003.
  • Williams, David E., George S. Bailey, Ashok Reddy, Jerry D. Hendricks, Aram Oganesian, Gayle A. Orner, Cliff B. Pereira, and James A. Swenberg. 2003. The rainbow trout (Oncorhynchus mykiss) tumor model: recent applications in low-dose exposures to tumor initiators and promoters. Toxicologic Pathology.   31(Suppl.1):58-61.
2002
  • Koc, Hasan and James A. Swenberg. 2002. Applications of mass spectrometry for quantitation of DNA adducts. Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences. 778(1-2):323-343.
  • Lin, Po-Hsiung, David K. La, Patricia B. Upton, and James A. Swenberg. 2002. Analysis of DNA adducts in rats exposed to pentachlorophenol. Carcinogenesis.   23(2):365-369.
  • Morinello, Eric J., Amy-Joan L. Ham, Asoka Ranasinghe, Jun Nakamura, Patricia B. Upton, and James A. Swenberg. 2002. Molecular dosimetry and repair of N2,3-ethenoguanine in rats exposed to vinyl chloride. Cancer Research.   62:5189-5195.
  • Morinello, Eric J., Hasan Koc, Asoka Ranasinghe, and James A. Swenberg. 2002. Differential induction of N2,3-ethenoguanine in rat brain and liver after exposure to vinyl chloride. Cancer Research.   62:5183-5188.
  • Sobol, Robert W., David E. Watson, Jun Nakamura, F. Michael Yakes, Esther Hou, Julie K. Horton, Jennifer Wu, Bennett Van Houten, James A. Swenberg, Kenneth R. Tindall, Leona D. Samson, and Samuel H. Wilson. 2002. Mutations associated with base excision repair deficiency and methylation-induced genotoxic stress. Proceedings of the National Academy of Sciences of the United States of America (PNAS).   99(14):6860-6865.
  • Swenberg, James A. 2002. Toxicological considerations in the application and interpretation of DNA adducts in epidemiologic studies. IARC Scientific Publications. 157:237-246.
  • Swenberg, James A., Nadia I. Georgieva, Amy-Joan L. Ham, Hasan Koc, Eric J. Morinello, Asoka Ranasinghe, Patricia B. Upton, and Vernon Walker. 2002. Linking pharmacokinetics and biomarker data to mechanism of action in risk assessment. Human and Ecological Risk Assessment: An International Journal.   8(6):1315-1338.
  • Swenberg, James A., Amy-Joan L. Ham, Hasan Koc, David K. La, Eric J. Morinello, Brian F. Pachkowski, Asoka Ranasinghe, and Patricia B. Upton. 2002. Methods for measuring DNA adducts and abasic sites II: Methods for measurement of DNA adducts. Current Protocols in Toxicology. 3.9.1-3.9.35.
  • Swenberg, James A., Amy-Joan L. Ham, K.S. McDorman, Eric J. Morinello, Jun Nakamura, and Robert Schoonhoven. 2002. Methods for measuring DNA adducts and abasic sites I: Isolation, purification, and analysis of DNA adducts in intact DNA. Current Protocols in Toxicology. 3.8.1-3.8.18.
  • Toraason, Mark, Mel Andersen, Matthew S. Bogdanffy, David Dankovic, Elaine M. Faustman, Paul Foster, Clay Frederick, Lynne Haber, Carole A. Kimmel, Steven Lewis, Roger McClellan, Ronald Melnick, Frank Mirer, Kevin Morgan, Val Schaeffer, Ellen K. Silbergeld, William Slikker, James A. Swenberg, and Harri Vainio. 2002. Improving risk assessment: Toxicological research needs. Human and Ecological Risk Assessment: An International Journal.   8(6):1405-1419.
2001
  • Ham, Amy-Joan L., C. Zhan, Hasan Koc, R.J. Hass, and James A. Swenberg. 2001. Analysis of 1,N6-ethenodeoxyguanosine by immunoaffinity/LC/MS/MS. In: Proceedings of the 49th ASMS (American Society for Mass Spectrometry) Conference on Mass Spectrometry and Allied Topics. June 4-7. Chicago, IL.
  • Lin, Po-Hsiung, Jun Nakamura, Shuji Yamaguchi, David K. La, and James A. Swenberg. 2001. Oxidative damage and direct adducts in calf thymus DNA induced by the pentachlorophenol metabolites, tetrachlorohydroquinone and tetrachloro-1,4-benzoquinone. Carcinogenesis.   22(4):627-634.
  • Lin, Po-Hsiung, Jun Nakamura, Shuji Yamaguchi, David K. La, Patricia B. Upton, and James A. Swenberg. 2001. Induction of direct adducts, apurinic/apyrimidinic sites, and oxidized bases in nuclear DNA of human HeLa S3 tumor cells by tetrachlorohydroquinone. Carcinogenesis.   22(4):635-639.
  • Morinello, Eric J., Amy-Joan L. Ham, Asoka Ranasinghe, Ramiah Sangaiah, and James A. Swenberg. 2001. Simultaneous quantitation of N2,3-ethenoguanine and 1,N2-ethenoguanine with immunoaffinity/gas chromatography/high resolution mass spectrometry. Chemical Research in Toxicology.   14:327-334.
2000
  • Boivin-Angele, Sandra, Lydie Lefrancois, Olivier Froment, Andreas Spiethoff, Matthew S. Bogdanffy, Kurt Wegener, Horst Wesch, Alain Barbin, Brigitte Bancel, Christian Trepo, Helmut Bartsch, James A. Swenberg, and Marie-Jean Marion. 2000. Ras gene mutations in vinyl chloride-induced liver tumours are carcinogen-specific but vary with cell type and species. International Journal of Cancer.   85(2):223-227.
  • Ham, Amy-Joan L., Asoka Ranasinghe, Hasan Koc, and James A. Swenberg. 2000. 4-Hydroxy-2-nonenal and ethyl linoleate from N2,3-ethenoguanine under peroxidizing conditions. Chemical Research in Toxicology.   13:1243-1250.
  • Hayes, Richard B., Luoping Zhang, Songnian Yin, James A. Swenberg, Li-qiang Xi, John K. Wiencke, William E. Bechtold, M. Yao, Nathaniel Rothman, Robert Haas, J. Patrick O'Neill, D. Zhang, Joseph L. Wiemels, Mustafa Dosemeci, Gui-Lan Li, and Martyn T. Smith. 2000. Genotoxic markers among butadiene-polymer workers in China. Carcinogenesis.   21(1):55-62.
  • Holt, Sharon, G. Roy, Soma R. Mitra, Patricia B. Upton, Matthew S. Bogdanffy, and James A. Swenberg. 2000. Deficiency of N-methylpurine-DNA-glycosylase expression in nonparenchymal cells, the target cell for vinyl chloride and vinyl fluoride. DNA Repair.   460(2):105-115.
  • Lin, Po-Hsiung, Ramiah Sangaiah, Asoka Ranasinghe, Patricia B. Upton, David K. La, Avram Gold, and James A. Swenberg. 2000. Formation of quinonoid-derived protein adducts in the liver and brain of Sprague-Dawley rats treated with 2,2',5,5'-tetrachlorobiphenyl. Chemical Research in Toxicology.   13(8):710-718.
  • Nakamura, Jun, David K. La, and James A. Swenberg. 2000. 5'-Nicked Apurinic/Apyrimidinic Sites Are Resistant to b-Elimination by b-Polymerase and Are Persistent in Human Cultured Cells after Oxidative Stress. Journal of Biological Chemistry.   275(8):5323-5328.
  • Rusyn, Ivan, Mikhail F. Denissenko, Victoria A. Wong, Byron E. Butterworth, Michael L. Cunningham, Patricia B. Upton, Ronald G. Thurman, and James A. Swenberg. 2000. Expression of base excision repair enzymes in rat and mouse liver is induced by peroxisome proliferators and is dependent upon carcinogenic potency. Carcinogenesis.   21(12):2141-2145.
  • Swenberg, James A., Nadia I. Christova-Gueoguieva, Patricia B. Upton, Asoka Ranasinghe, Nova A. Scheller, Kuen-Yuh Wu, Ten-Yang Yen, and Richard B. Hayes. 2000. Hemoglobin adducts as biomarkers of butadiene exposure and metabolism. HEI Research Report No. 92: 1,3-Butadiene and its metabolites: Interspecies comparison of carcinogenicity, mutagenicity and biomarkers. Part V. Hemoglobin adducts as biomarkers of butadiene exposure and metabolism. pp.191-219.
  • Swenberg, James A., Amy-Joan L. Ham, Hasan Koc, Eric J. Morinello, Asoka Ranasinghe, Natalia Tretyakova, Patricia B. Upton, and Kuen-Yuh Wu. 2000. DNA adducts: effects of low exposure to ethylene oxide, vinyl chloride and butadiene. Mutation Research/Genetic Toxicology and Environmental Mutagenesis.   464(1):77-86. doi:10.1016/S1383-5718(99)00168-0  
  • Walker, Vernon, Kuen-Yuh Wu, Patricia B. Upton, Asoka Ranasinghe, Nova A. Scheller, Myung-Haeng Cho, Jane S. Vergnes, Thomas R. Skopek, and James A. Swenberg. 2000. Biomarkers of exposure and effect as indicators of potential carcinogenic risk arising from in vivo metabolism of ethylene to ethylene oxide. Carcinogenesis.   21(9):1661-1669.
1999
  • Ham, Amy-Joan L., Asoka Ranasinghe, Eric J. Morinello, Jun Nakamura, Patricia B. Upton, Francis Johnson, and James A. Swenberg. 1999. Immunoaffinity/gas chromatography/high resolution mass spectrometry method for the detection of N2,3-ethenoguanine. Chemical Research in Toxicology.   12:1240-1246.
  • Holt, Sharon, Matthew S. Bogdanffy, and James A. Swenberg. 1999. The molecular dosimetry and repair of vinyl fluoride-induced DNA adducts. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.335.
  • Ito, Norio, David K. La, Sharon Holt, T.R. Craft, R.C. Sills, and James A. Swenberg. 1999. Analysis of ras mutations in forestomach tumors from B6C3F1 mice exposed to 1,2,3-trichloropropane. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.137.
  • La, David K. and James A. Swenberg. 1999. The induction of endogenous DNA adducts in tissues of Fischer-344 rats following gavage administration of 1,2,3-trichloropropane. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.131.
  • La, David K., Po-Hsiung Lin, and James A. Swenberg. 1999. Analysis of DNA Adducts in rats chronically exposed to pentachlorophenol. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.330.
  • Lin, Po-Hsiung, Ramiah Sangaiah, and James A. Swenberg. 1999. Adducts of 2,3,2',5'-tetrachlorobiphenyl-derived ortho-quinone with rat liver proteins after metabolic activation in vitro. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.330.
  • Lin, Po-Hsiung, Suramya Waidyanatha, Gary M. Pollack, James A. Swenberg, and Stephen M. Rappaport. 1999. Dose-specific production of chlorinated quinone and semiquinone adducts in rodent livers following administration of pentachlorophenol. Toxicological Sciences.   47(1):126-133.
  • Mitro, K.L., Nova A. Scheller, Asoka Ranasinghe, and James A. Swenberg. 1999. Quantitation of endogenous N2,3-ethenoguanine in human and rat liver DNA using high resolution mass spectrometry. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.847.
  • Nakamura, Jun and James A. Swenberg. 1999. Endogenous apurinic/apyrimidinic sites in genomic DNA of mammalian tissues. Cancer Research.   59(11):2522-2526.
  • Nakamura, Jun, Vernon Walker, Patricia B. Upton, and James A. Swenberg. 1999. Characterization of a newly developed AP site assay that uses an aldehyde reactive probe-Slot-Blot method. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.480.
  • Swenberg, James A. and Lois D. Lehman-McKeeman. 1999. Urinary globulin-associated nephropathy as a mechanism of renal tubular cell carcinogenesis in male rats. IARC Scientific Publications. 147:95-118.
  • Swenberg, James A., Matthew S. Bogdanffy, Amy-Joan L. Ham, Sharon Holt, A.H. Kim, Eric J. Morinello, Asoka Ranasinghe, Nova A. Scheller, and Patricia B. Upton. 1999. Formation and repair of DNA adducts in vinyl chloride- and vinyl fluoride- induced carcinogenesis. IARC Scientific Publications. 150:29-43.
  • Wu, Kuen-Yuh, Asoka Ranasinghe, Patricia B. Upton, Nova A. Scheller, and James A. Swenberg. 1999. Endogenous formation of the major DNA adduct of ethylene oxide in humans, rats, and mice. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.102.
  • Wu, Kuen-Yuh, Asoka Ranasinghe, Patricia B. Upton, Vernon Walker, and James A. Swenberg. 1999. Molecular dosimetry of endogenous and ethylene oxide-induced N7-(2-hydroxyethyl)guanine formation in tissues of rodents. Carcinogenesis.   20:1787-1792.
  • Wu, Kuen-Yuh, Nova A. Scheller, Myung-Haeng Cho, Asoka Ranasinghe, Patricia B. Upton, Vernon Walker, and James A. Swenberg. 1999. Molecular dosimetry of hydroxyethyl adducts in DNA and hemoglobin following exposure of rats and mice to ethylene. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.839.
  • Wu, Kuen-Yuh, Nova A. Scheller, Asoka Ranasinghe, Ten-Yang Yen, Ramiah Sangaiah, Roger W. Giese, and James A. Swenberg. 1999. A gas chromatography/electron capture/negative chemical ionization-high resolution mass spectrometry method for analysis of endogenous and exogenous N7-(2-hydroxyethyl)guanine in rodents and its potential for human biological monitoring. Chemical Research in Toxicology.   12(8):722-729.
1998
  • Ham, Amy-Joan L. and James A. Swenberg. 1998. Immunoaffinity (IA) gas chromatography/mass spectometry (GC/MS) method for N2,3-ethenoguanine demonstrates importance of hydrolysis method for adduct quantitation. Fundamental and Applied Toxicology.   42:180.
  • Holt, Sharon, Ramiah Sangaiah, and James A. Swenberg. 1998. Detection of 1,N6-Ethenoadenine in Rat Urine After Chloroethylene Oxide Exposure. Carcinogenesis.   19(10):1763-1769.
  • Holt, Sharon, Nova A. Scheller, Soma R. Mitra, Matthew S. Bogdanffy, and James A. Swenberg. 1998. Formation and repair of vinyl fluoride-induced DNA adducts. Fundamental and Applied Toxicology.   42:180.
  • Law, J.McHugh, M. Bull, Jun Nakamura, and James A. Swenberg. 1998. Molecular dosimetry of DNA adducts in the medaka small fish model. Carcinogenesis.   19(3):515-518.
  • Nakamura, Jun, Vernon Walker, Patricia B. Upton, Su-Yin Chiang, Y.W. Kow, and James A. Swenberg. 1998. Highly sensitive AP site assay can detect spontaneous and chemically-induced depurination under physiological conditions. Cancer Research.   58(2):222-225.
  • Ploch, S.A., Jun Nakamura, James A. Swenberg, and Richard T. Di Giulio. 1998. Assessment of AP site formation in isolated hepatocytes from brown bullhead upon treatment with benzo(a)pyrene. Fundamental and Applied Toxicology.   42:82.
  • Ranasinghe, Asoka, Amy-Joan L. Ham, Eric J. Morinello, and James A. Swenberg. 1998. Quantitation of 1, N2-ethenoguanine and N2, 3-ethenoguanine by IAC/GC/ECNCI/HRMS. In: Proceedings of the 46th ASMS (American Society for Mass Spectrometry) Conference on Mass Spectrometry and Allied Topics.
  • Ranasinghe, Asoka, Nova A. Scheller, Kuen-Yuh Wu, Patricia B. Upton, and James A. Swenberg. 1998. Application of Gas Chromatography/Electron Capture Negative Chemical Ionization/High Resolution Mass spectrometry for Analysis of DNA and Protein Adducts. Chemical Research in Toxicology.   11:520-526.
  • Yen, Ten-Yang, Sharon Holt, Ramiah Sangaiah, Avram Gold, and James A. Swenberg. 1998. Quantitation of 1,N6 Ethenoadenine in Rat Urine by Immunoaffinity Extraction Combined with Liquid Chromatography/Electrospray Ionization Mass Spectrometry. Chemical Research in Toxicology.   11(7):810-815.
1997
  • La, David K. and James A. Swenberg. 1997. Carcinogenic alkylating agents. In: Comprehensive Toxicology, Vol. 12, Chemical Carcinogens and Anticarcinogens. Elsevier Science, Oxford, United Kingdom. pp.111-140.
  • Scheller, Nova A., Asoka Ranasinghe, Matthew S. Bogdanffy, and James A. Swenberg. 1997. Detection of N2,3-ethenoguanine by GC/HR-MS in brains and kidneys in vinyl fluoride exposed rodents. Fundamental and Applied Toxicology.   36:94.
  • Swenberg, James A. 1997. Generating data for scientifically-based risk assessment. Fundamental and Applied Toxicology.   36:286.
  • Swenberg, James A. 1997. In vivo studies on the formation and repair of DNA adducts. In: Proceedings of Environmental Mutagen Society Meeting, 1997. Minneapolis, MN.
  • Wu, Kuen-Yuh, Asoka Ranasinghe, Nova A. Scheller, Patricia B. Upton, and James A. Swenberg. 1997. Mechanism-based risk assessment: Utility of DNA adducts in model selection. Fundamental and Applied Toxicology.   36:97.
  • Yen, Ten-Yang, Kuen-Yuh Wu, Sharon Holt, Ramiah Sangaiah, and James A. Swenberg. 1997. Determination of DNA adducts from ethylene oxide and vinyl chloride exposure. In: Proceedings of the 45th AMS (American Society of Microbiology) Conference on Mass Spectrometry and Allied Topics. pp.295.
1996
  • Chiang, Su-Yin, James A. Swenberg, Wade A. Weisman, and Thomas R. Skopek. 1996. Mutagenicity of vinyl chloride and its reactive metabolites, chloroethylene oxide and chloroacetaldehyde, in a metabolically competent human B-lymphoblastoid line. Carcinogenesis.   18(1):31-36.
  • Christova-Gueoguieva, Nadia I., Ten-Yang Yen, Nova A. Scheller, Sharon Holt, and James A. Swenberg. 1996. Quantitation of N2,3-ethenoguanine (εG) in rat liver by liquid chromatography-electrospray mass spectrometry. The Toxicologist.   30(1,part2):235.
  • Holt, Sharon and James A. Swenberg. 1996. Age-dependent modulation of tissue-specific repair activity for methylpurine glycosylase. The Toxicologist.   30(1,part2):236.
  • La, David K., Robert Schoonhoven, Norio Ito, and James A. Swenberg. 1996. The effects of exposure route on DNA adduct formation and cellular proliferation by 1,2,3-trichloropropane. Toxicology and Applied Pharmacology.   140(1):108-114.
  • La, David K., James A. Swenberg, Amy-Joan L. Ham, Hasan Koc, Eric J. Morinello, Asoka Ranasinghe, Natalia Tretyakova, Patricia B. Upton, and Kuen-Yuh Wu. 1996. DNA adducts: Biological markers of exposure and potential applications to risk assessment. Mutation Research.   365:129-146.
  • Ranasinghe, Asoka, Nova A. Scheller, Kuen-Yuh Wu, and James A. Swenberg. 1996. GC/ECNCI/MS/MS Analysis of electrophore-labeled DNA adducts. In: Proceedings of the 44th ASMS (American Society for Mass Spectrometry) on Mass Spectrometry and Allied Topics. Portland, OR.
  • Scheller, Nova A., Asoka Ranasinghe, Nadia I. Christova-Gueoguieva, Ten-Yang Yen, Amy-Joan L. Ham, and James A. Swenberg. 1996. Detection of Endogenous N2,3-ethenoguanine by GC/ECNCI/MS. In: Proceedings of the 44th ASMS (American Society for Mass Spectrometry) on Mass Spectrometry and Allied Topics. Portland, OR. pp.781.
  • Swenberg, James A., David K. La, Nova A. Scheller, and Kuen-Yuh Wu. 1996. Dose-response relationships for carcinogens. Toxicology Letters.   82-3:751-756.
  • Swenberg, James A., Nova A. Scheller, Asoka Ranasinghe, Patricia B. Upton, Nadia I. Christova-Gueoguieva, and Matthew S. Bogdanffy. 1996. Molecular dosimetry of N2,3-ethenoguanine in DNA of vinyl fluoride-exposed rats: Relationship to hemangiosarcoma. The Toxicologist.   30(1,part2):235.
  • Yen, Ten-Yang, Nadia I. Christova-Gueoguieva, Nova A. Scheller, Sharon Holt, James A. Swenberg, and M. Judith Charles. 1996. HPLC/ESI/MS May be the Technique of Choice for the Analysis of Certain DNA Adducts. In: Proceedings of the 44th ASMS (American Society for Mass Spectrometry) on Mass Spectrometry and Allied Topics. Portland, OR. pp.780.
  • Yen, Ten-Yang, Nadia I. Christova-Gueoguieva, Nova A. Scheller, Sharon Holt, James A. Swenberg, and M. Judith Charles. 1996. Quantitative analysis of the DNA N2,3-Ethenoguanine using liquid chromatography/electrospray ionization mass spectrometry. Journal of Mass Spectrometry.   31(11):1271-1276.
1995
  • Chiang, Su-Yin, T.R. Craft, Thomas R. Skopek, and James A. Swenberg. 1995. Mutation spectra of vinyl chloride (VC) and chloroethylene oxide (CEO) at the hprt gene in metabolically-competent human lymphoblastoid lines. International Toxicologist. 7(1):46P9.
  • Chiang, Su-Yin, Thomas R. Skopek, and James A. Swenberg. 1995. Mutagenicity of vinyl chloride and its metabolites, and vinyl fluoride in a metabolically competent human lymphoblastoid line. The Toxicologist.   15(1):79.
  • Holt, Sharon and James A. Swenberg. 1995. Detection of 1,N6-ethenoadenine excreted in rat urine after chloroethylene oxide exposure. The Toxicologist.   15(1):77.
  • Scheller, Nova A., Asoka Ranasinghe, A.H. Kim, Sharon Holt, Matthew S. Bogdanffy, and James A. Swenberg. 1995. High resolution GC/MS detection of N2,3-ethenoguanine in livers of control and vinyl fluoride-exposed B6C3F1 mice. International Toxicologist. 7(1):6P21.
  • Scheller, Nova A., Ramiah Sangaiah, Asoka Ranasinghe, Venkataraman Amarnath, Avram Gold, and James A. Swenberg. 1995. Synthesis of [4,5,6,8-13C4]guanine, a reagent for the production of internal standards of guanyl DNA adducts. Chemical Research in Toxicology.   8(3):333-337.
  • Swenberg, James A. 1995. Bioassay design and MTD setting: Old methods and new approaches. Regulatory Toxicology and Pharmacology.   21:44-51.
  • Swenberg, James A. 1995. Carcinogenesis. In: Patty's Industrial Hygiene and Toxicology, 3rd edition, Volume 4, Part B. Wiley and Sons, New York, NY. pp.255-273.
  • Yen, Ten-Yang, Nadia I. Christova-Gueoguieva, Nova A. Scheller, James A. Swenberg, and M. Judith Charles. 1995. Quantitative analysis of DNA adducts by using HPLC/ESI-MS. In: Proceedings of the 43rd ASMS (American Society for Mass Spectrometry) Conference on Mass Spectrometry and Allied Topics. pp.497.