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National Institute of Environmental Health Sciences

 

Person Details

Superfund Research Program

Clement E. Furlong

University of Washington
Department of Medicine and Genome Sciences
Division of Medical Genetics
Seattle, WA 98195
Phone: (206) 543-1193
Fax: (206) 543-3050
Email:

Projects

Research Briefs

Patents

  • Engineered Recombinant Human Paraoxonase 1 (rHuPON1) Purified from E. coli Protects against Organophosphate Poisoning
  • Methods of Determining the Activity of Paraoxonase 1 (PON1) and Use Of Pon1 Status as a Biomarker for Parkinsons Disease
  • Methods of Determining Paraoxonase 1 (PON1) Status in a Mammalian Subject

Publications

2014
  • Cole, Toby B., W.F. Li, Aila L. Co, Ariel M. Hay, James W. MacDonald, Theodor K. Bammler, Federico M. Farin, Lucio G. Costa, and Clement E. Furlong. 2014. Repeated gestational exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1) modulated effects in maternal and fetal tissues. Toxicological Sciences. 141(2):409-422. doi:10.1093/toxsci/kfu144  
  • Costa, Lucio G., Rian de Laat, Khoi Dao, Claudia Pellacani, Toby B. Cole, and Clement E. Furlong. 2014. Paraoxonase-2 (PON2) in brain and its potential role in neuroprotection. NeuroToxicology.   43:3-9. doi:10.1016/j.neuro.2013.08.011  
2013
  • Baker, Paul E., Toby B. Cole, Megan Cartwright, Stephanie M. Suzuki, Kenneth E. Thummel, Yvonne S. Lin, Aila L. Co, Allan E. Rettie, Jerry H. Kim, and Clement E. Furlong. 2013. Identifying safer anti-wear triaryl phosphate additives for jet engine lubricants. Chemico-Biological Interactions.   203(1):257-264. doi:10.1016/j.cbi.2012.10.005  
  • Costa, Lucio G., Gennaro Giordano, Toby B. Cole, Judit Marsillach, and Clement E. Furlong. 2013. Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity. Toxicology.   307:115-122. doi:10.1016/j.tox.2012.07.011  
  • Costa, Lucio G., Leah Tait, Rian de Laat, Khoi Dao, Gennaro Giordano, Claudia Pellacani, Toby B. Cole, and Clement E. Furlong. 2013. Modulation of paraoxonase 2 (PON2) in mouse brain by the polyphenol quercetin: A mechanism of neuroprotection?. Neurochemical Research. 38(9):1809-1818. doi:10.1007/s11064-013-1085-1  
  • Giordano, Gennaro, Leah Tait, Clement E. Furlong, Toby B. Cole, Terrance J. Kavanagh, and Lucio G. Costa. 2013. Gender differences in brain susceptibility to oxidative stress are mediated by levels of paraoxonase-2 expression. Free Radical Biology and Medicine.   58:98-108. doi:10.1016/j.freeradbiomed.2013.01.019  
  • Kim, Daniel Seung, Judit Marsillach, Clement E. Furlong, and Gail P. Jarvik. 2013. Pharmacogenetics of paraoxonase activity: Elucidating the role of high-density lipoprotein in disease. Pharmacogenomics. 14:1495-1515. doi:10.2217/pgs.13.147  
  • Marsillach, Judit, Lucio G. Costa, and Clement E. Furlong. 2013. Protein adducts as biomarkers of exposure to organophosphorus compounds. Toxicology.   307:46-54. doi:10.1016/j.tox.2012.12.007  
  • Marsillach, Judit, Edward J. Hsieh, Rebecca J. Richter, Michael J. MacCoss, and Clement E. Furlong. 2013. Proteomic analysis of adducted butyrylcholinesterase for biomonitoring organophosphorus exposures. Chemico-Biological Interactions.   203(1):85-90. doi:10.1016/j.cbi.2012.10.019  
2012
2011
  • Cole, Toby B., Richard P. Beyer, Theodor K. Bammler, Sarah S. Park, Federico M. Farin, Lucio G. Costa, and Clement E. Furlong. 2011. Repeated Developmental Exposure of Mice to Chlorpyrifos Oxon Is Associated with Paraoxonase 1 (PON1)-Modulated Effects on Cerebellar Gene Expression. Toxicological Sciences.   123:155-169. doi:10.1093/toxsci/kfr157  
  • Costa, Lucio G. and Clement E. Furlong. 2011. Paraoxonase 1: Structure, Function and Polymorphisms. Chapter 7 in: Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology. Wiley, Hoboken, NJ. pp.85-96.
  • Costa, Lucio G., Gennaro Giordano, and Clement E. Furlong. 2011. Pharmacological and dietary modulators of paraoxonase 1 (PON1) activity and expression: The hunt goes on. Biochemical Pharmacology.   81(3):337-344. doi:10.1016/j.bcp.2010.11.008  
  • Giordano, Gennaro, Toby B. Cole, Clement E. Furlong, and Lucio G. Costa. 2011. Paraoxonase 2 (PON2) in the mouse central nervous system: A neuroprotective role?. Toxicology and Applied Pharmacology.   256:369-378. doi:10.1016/j.taap.2011.02.014  
  • Kim, Jerry H., Richard C. Stevens, Michael J. MacCoss, David R. Goodlett, Alex Scherl, Rebecca J. Richter, Stephanie M. Suzuki, Clement E. Furlong, Judit Marsillach, Daniela Tomazela, Lawrence M. Schopfer, and Oksana Lockridge. 2011. Biomarkers of organophosphorus (OP) exposures in humans. NeuroToxicology.   32:656-660. doi:10.1016/j.neuro.2011.06.005  
  • Liyasova, M., B. Li, Lawrence M. Schopfer, Florian Nachon, Patrick Masson, Clement E. Furlong, and Oksana Lockridge. 2011. Exposure to tri-o-cresyl phosphate detected in jet airplant passengers. Toxicology and Applied Pharmacology.   256:337-347. doi:10.1016/j.taap.2011.06.016  
2010
  • Cole, Toby B., Sarah S. Park, W.F. Li, Clement E. Furlong, Lucio G. Costa, and Karen L. Jansen. 2010. The Toxicity of Mixtures of Specific Organophosphorus (OP) Compounds is Modulated by Paraoxonase 1 Status. Advances in Experimental Medicine and Biology.   660:47-60. doi:10.1007/978-1-60761-350-3_6  
  • Furlong, Clement E., Stephanie M. Suzuki, Richard C. Stevens, Judit Marsillach, Rebecca J. Richter, Gail P. Jarvik, Harvey Checkoway, Ali Samii, Lucio G. Costa, Alida Griffith, John W. Roberts, Dora Yearout, and Cyrus P. Zabetian. 2010. Human PON1, a biomarker of risk of disease and exposure. Chemico-Biological Interactions.   187(1-3):355-361. doi:10.1016/j.cbi.2010.03.033  
  • Hofmann, Jonathan N., Matthew Keifer, Harvey Checkoway, Anneclaire J. De Roos, Federico M. Farin, Richard A. Fenske, Rebecca J. Richter, Gerald van Belle, and Clement E. Furlong. 2010. Biomarkers of Sensitivity and Exposure in Washington State Pesticide Handlers. Advances in Experimental Medicine and Biology.   660:19-27. doi:10.1007/978-1-60761-350-3_3  
  • Hofmann, Jonathan N., Matthew Keifer, Anneclaire J. De Roos, Richard A. Fenske, Clement E. Furlong, Gerald van Belle, and Harvey Checkoway. 2010. Occupational determinants of serum cholinesterase inhibition among organophosphate-exposed agricultural pesticide handlers in Washington State. Occupational and Environmental Medicine.   67:375-386. doi:10.1136/oem.2009.046391  
  • Kim, Jerry H., Richard C. Stevens, Michael J. MacCoss, David R. Goodlett, Alex Scherl, Rebecca J. Richter, Stephanie M. Suzuki, and Clement E. Furlong. 2010. Identification and Characterization of Biomarkers of Organophosphorus (OP) Exposures in Humans. Advances in Experimental Medicine and Biology.   660:61-71. doi:10.1007/978-1-60761-350-3_7  
  • Richter, Rebecca J., Toby B. Cole, Sarah S. Park, Tamara C. Otto, Douglas M. Cerasoli, David E. Lenz, Clement E. Furlong, Stephanie M. Suzuki, and Richard C. Stevens. 2010. Engineering Human P0N1 in an E. coli Expression System. In: Paraoxonases in Inflammation, Infection and Toxicology. Humana Press, pp.37-46.
  • Richter, Rebecca J., Gail P. Jarvik, and Clement E. Furlong. 2010. Paraoxonase 1 Status as a Risk Factor for Disease or Exposure. Advances in Experimental Medicine and Biology.   660:29-35. doi:10.1007/978-1-60761-350-3_4  
  • Ross, S., C. Brewin, H. Curran, Clement E. Furlong, K. Abraham-Smith, and V. Harrison. 2010. Neuropsychological and psychiatric functioning in sheep farmers exposed to low levels of organophosphate pesticides. Neurotoxicology and Teratology.   32(4):452-459. doi:10.1016/j.ntt.2010.03.004  
  • Schopfer, L., Clement E. Furlong, and Oksana Lockridge. 2010. Development of diagnostics in the search for an explanation of aerotoxic syndrome. Analytical Biochemistry.   404(1):64-74. doi:10.1016/j.ab.2010.04.032  
  • Suzuki, Stephanie M., Richard C. Stevens, Rebecca J. Richter, Toby B. Cole, Sarah S. Park, Tamara C. Otto, Douglas M. Cerasoli, David E. Lenz, and Clement E. Furlong. 2010. Engineering Human PON1 in an E. coli Expression System. Advances in Experimental Medicine and Biology.   660:37-45. doi:10.1007/978-1-60761-350-3_5  
  • Ticozzi, N., A.L. LeClerc, P.J. Keagle, J.D. Glass, A.M. Wills, M. van Blitterswijk, D.A. Bosco, I. Rodriguez-Leyva, C. Gellera, A. Ratti, F. Taroni, D. McKenna-Yasek, P.C. Sapp, V. Silvani, Clement E. Furlong, R.H. Brown, and J.E. Landers. 2010. Paraoxonase gene mutations in amyotrophic lateral sclerosis. Annals of Neurology.   68(1):102-107. doi:10.1002/ana.21993  
2009
  • Hofmann, Jonathan N., Matthew Keifer, Clement E. Furlong, Anneclaire J. De Roos, Federico M. Farin, Richard A. Fenske, Gerald van Belle, and Harvey Checkoway. 2009. Serum Cholinesterase Inhibition in Relation to Paraoxonase-1 (PON1) Status among Organophosphate-Exposed Agricultural Pesticide Handlers. Environmental Health Perspectives. 117:1402-1408.
  • Huen, Karen, Rebecca J. Richter, Clement E. Furlong, Brenda Eskenazi, and Nina T. Holland. 2009. Validation of PON1 enzyme activity assays for longitudinal studies. Clinica Chimica Acta.   402(1-2):67-74. doi:10.1016/j.cca.2008.12.019  
  • Jansen, Karen L., Toby B. Cole, Sarah S. Park, Clement E. Furlong, and Lucio G. Costa. 2009. Paraoxonase 1 (P0N1) Modulates the Toxicity of Mixed Organophosphorus Compounds. Toxicology and Applied Pharmacology.   236(2):142-153. doi:10.1016/j.taap.2009.02.001  
  • Richter, Rebecca J., Gail P. Jarvik, and Clement E. Furlong. 2009. Paraoxonase 1 (PON1) status and substrate hydrolysis. Toxicology and Applied Pharmacology.   235(1):1-9. doi:10.1016/j.taap.2008.11.001  
2008
2007
2006
  • Costa, Lucio G., Toby B. Cole, and Clement E. Furlong. 2006. Gene-environment interactions: Paraoxonase (PON1) and sensitivity to organophosphate toxicity. LabMedicine.   37(2):109-113.
  • Costa, Lucio G., Toby B. Cole, and Clement E. Furlong. 2006. Genetic ponymorphisms of human paraoxonase (PON1) and susceptibility to organophosphorous insecticide toxicity. In: 28th International Congress on Occupational Health (ICOH); May 11-16. Milan, Italy.
  • Costa, Lucio G., Toby B. Cole, and Clement E. Furlong. 2006. PON1 and organophosphate toxicity. In: 2nd International Conference on paraoxonases; September 7-10. Debrecen, Hungary.
  • Costa, Lucio G., Toby B. Cole, Annabella Vitalone, and Clement E. Furlong. 2006. Paraoxonase polymorphisms and toxicity of organophosphates. Toxicology of Organophosphate and Carbamate Pesticides.  
  • Furlong, Clement E. 2006. A surface plasmon resonance (SPR)-based sensor system for near real-time monitoring of analytes. In: Center for Process Analytical Chemistry Fall Sponser Meeting, November 7-10. Seattle, WA.
  • Furlong, Clement E., Toby B. Cole, Rebecca J. Richter, V. Brophy, Christopher S. Carlson, R. Rieder, Deborah A. Nickerson, Lucio G. Costa, Jane Ranchalis, Gail P. Jarvik, Aldons J. Lusis, Diana M. Shih, and Aaron Tward. 2006. The functional consequences of polymorphisms in the human PON1 gene. In: 2nd International Conference on paraoxonases; September 7-10. Debrecen, Hungary.
2005
  • Cole, Toby B., Betsy J. Walter, Diana M. Shih, Aaron Tward, Aldons J. Lusis, Charles Timchalk, Rebecca J. Richter, Lucio G. Costa, and Clement E. Furlong. 2005. Toxicity of chlorpyrifos and chlorpyrifos oxon in a transgenic mouse model of the human paraoxonase (PON1) Q192R polymorphism. Pharmacogenetics and Genomics.   15(8):589-598.
  • Costa, Lucio G., Toby B. Cole, and Clement E. Furlong. 2005. Paraoxonase (PON1): from toxicology to cardiovascular medicine. Acta Bio-Medica de I Ateneo Parmense. 76Suppl.2:50-57.
  • Costa, Lucio G., Toby B. Cole, Annabella Vitalone, and Clement E. Furlong. 2005. Measurement of paraoxonase (PON1) status as a potential biomarker of susceptibility to organophosphate toxicity. Clinica Chimica Acta.   352(1-2):37-47.
  • Costa, Lucio G., Annabella Vitalone, Toby B. Cole, and Clement E. Furlong. 2005. Modulation of paraoxonase (PON1) activity. Biochemical Pharmacology.   69(4):541-550.
  • Furlong, Clement E., Toby B. Cole, Gail P. Jarvik, Christina Pettan-Brewer, Gary K. Geiss, Rebecca J. Richter, Diana M. Shih, Aaron Tward, Aldons J. Lusis, and Lucio G. Costa. 2005. Role of paraoxonase (PON1) status in pesticide sensitivity: genetic and temporal determinants. NeuroToxicology.   26(4):651-659.
  • Furlong, Clement E., Toby B. Cole, Betsy J. Walter, Diana M. Shih, Aaron Tward, Aldons J. Lusis, Charles Timchalk, Rebecca J. Richter, and Lucio G. Costa. 2005. Paraoxonase 1 (PON1) status and risk of insecticide exposure. Journal of Biochemical and Molecular Toxicology.   19(3):182-183.
2004
  • Costa, Lucio G., Samir N. Kelada, Paola Costa-Mallen, Federico M. Farin, Hanna A. Viernes, Terri Smith-Weller, Gary M. Franklin, William T. Longstreth, Phillip D. Swanson, Harvey Checkoway, and Clement E. Furlong. 2004. Paraoxonase 2 (PON2) polymorphisms and Parkinson's disease. Neuroscience Research Communications.   34(3):130-135.
  • Furlong, Clement E., Toby B. Cole, Gail P. Jarvik, Christina Pettan-Brewer, Gary K. Geiss, Rebecca J. Richter, Diana M. Shih, Aaron Tward, Aldons J. Lusis, and Lucio G. Costa. 2004. Role of paraoxonase (PON1) status in pesticide sensitivity; genetic and temporal determinants. NeuroToxicology.   26(4):651-659.
2003
  • Cole, Toby B., Rachel L. Jampsa, Betsy J. Walter, Tara L. Arndt, Rebecca J. Richter, Diana M. Shih, Aaron Tward, Aldons J. Lusis, Rhona M. Jack, Lucio G. Costa, and Clement E. Furlong. 2003. Expression of human paraoxonase (PON1) during development. Pharmacogenetics and Genomics.   13(6):357-364.
  • Costa, Lucio G., Toby B. Cole, and Clement E. Furlong. 2003. Polymorphisms of paraoxonse (PONl)and their significance in clinical toxicology of organophosphates. Toxicology.   41(1):37-45.
  • Costa, Lucio G., Toby B. Cole, Gail P. Jarvik, and Clement E. Furlong. 2003. Functional genomic of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism. Annual Review of Medicine.   54:371-392.
  • Costa, Lucio G., Rebecca J. Richter, W.E. Li, Toby B. Cole, Marina Guizzetti, and Clement E. Furlong. 2003. Paraoxonase (PON 1) as a biomarker of susceptibility for organophosphate toxicity. Biomarkers.   8(1):1-12.
  • Kelada, Samir N., Paola Costa-Mallen, Harvey Checkoway, Hanna A. Viernes, Federico M. Farin, Lucio G. Costa, William T. Longstreth, Clement E. Furlong, Gail P. Jarvik, and Phillip D. Swanson. 2003. Paraoxonase 1 promoter and coding region polymorphisms in Parkinson's disease. Journal of Neurology, Neurosurgery & Psychiatry.   74(4):546-547.
2002
  • Costa, Lucio G. and Clement E. Furlong. 2002. Perspectives in PONI research. Chapter 10. In: Paraoxonase (PON1) in Health and Disease: Basic and Clinical Aspects. Kluwer Academic Publishers, pp.197-210.
  • Costa, Lucio G., W.F. Li, Rebecca J. Richter, Diana M. Shih, Aldons J. Lusis, and Clement E. Furlong. 2002. PONl and organophosphate toxicity. Chapter 8. In: Paraoxonase (PON1) in Health and Disease: Basic and Clinical Aspects. Kluwer Academic Publishers, pp.165-183.
  • Furlong, Clement E., Toby B. Cole, Gail P. Jarvik, and Lucio G. Costa. 2002. Pharmacogenomic considerations of the paraoxonase polymorphisms. Pharmacogenetics and Genomics.   3(3):341-348.