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National Institute of Environmental Health Sciences

 

Person Details

Superfund Research Program

Margaret R. Karagas

Dartmouth College
Department of Community and Family Medicine
7927 Norris Cotton Cancer Center
One Medical Center Drive
Lebanon, NH 03756-1000
Phone: 603-653-9010
Fax: 603-653-0578
Email:

Projects

Research Briefs

Superfund Sites

18 SF sites in State of New Hampshire

  • Dartmouth College: Epidemiology, Biomarkers and Exposure Assessment of Metals

Elizabeth Mine

  • Dartmouth College: Epidemiology, Biomarkers and Exposure Assessment of Metals

Sites in Concord, New Hampshire

  • Dartmouth College: Epidemiology, Biomarkers and Exposure Assessment of Metals

Sites in Lebanon, New Hampshire and Surrounding Communities

  • Dartmouth College: Epidemiology, Biomarkers and Exposure Assessment of Metals

Publications

2014
  • Koestler, Devin C., Jing Li, John A. Baron, Gregory J. Tsongalis, Lynn F. Butterly, Martha Goodrich, Corina Lesseur, Margaret R. Karagas, Carmen J. Marsit, Jason H. Moore, Angeline S. Andrew, and Amitabh Srivastava. 2014. Distinct patterns of DNA methylation in conventional adenomas involving the right and left colon. Modern Pathology. 27:145-155. doi:10.1038/modpathol.2013.104  
  • Pan, Qinxin, Ting Hu, James D. Malley, Angeline S. Andrew, Margaret R. Karagas, and Jason H. Moore. 2014. A system-level pathway-phenotype association analysis using synthetic feature random forest. Genetic Epidemiology. 38:209-219. doi:10.1002/gepi.21794  
2013
  • Cottingham, Kathyrn L., Roxanne Karimi, Joann F. Gruber, Michael S. Zens, Vicki Sayarath, Carol L. Folt, Tracy Punshon, Margaret R. Karagas, and J. Steven Morris. 2013. Diet and toenail arsenic concentrations in a New Hampshire population with arsenic-containing water. Nutrition Journal. 12:149. doi:10.1186/1475-2891-12-149  
  • Fei, Dennis L., Devin C. Koestler, Zhigang Li, Camilla Giambelli, Avencia Sanchez-Mejias, Julie A. Gosse, Carmen J. Marsit, Margaret R. Karagas, and David J. Robbins. 2013. Association between In Utero arsenic exposure, placental gene expression, and infant birth weight: A US birth cohort study. Environmental Health.   12:doi:10.1186/1476-069X-12-58  
  • Gilbert-Diamond, Diane, Zhigang Li, Ann E. Perry, Steven K. Spencer, A Jay Gandolfi, and Margaret R. Karagas. 2013. A population-based case-control study of urinary arsenic species and squamous cell carcinoma in New Hampshire, USA. Environmental Health Perspectives. 121(10):1154-1160. doi:10.1289/ehp.1206178  
  • Hu, Ting, Angeline S. Andrew, Margaret R. Karagas, and Jason H. Moore. 2013. Statistical epistasis networks reduce the computational complexity of searching three-locus genetic models. Pacific Symposium on Biocomputing. 397-408. doi:10.1142/9789814447973_0039  
  • Saunders, J.E., B.G. Jastrzembski, J.C. Buckey, D. Enriquez, Todd A. MacKenzie, and Margaret R. Karagas. 2013. Hearing loss and heavy metal toxicity in a Nicaraguan mining community: Audiological results and case reports. Audiology & Neuro-otology. 18:101-113. doi:10.1159/000345470  
  • Urbanowicz, Ryan J., Angeline S. Andrew, Margaret R. Karagas, and Jason H. Moore. 2013. Role of genetic heterogeneity and epistasis in bladder cancer susceptibility and outcome: A learning classifier system approach. Journal of the American Medical Informatics Association. 20:603-612. doi:10.1136/amiajnl-2012-001574  
  • Wyszynski, Asaf, Sam A. Tanyos, Judy R. Rees, Carmen J. Marsit, Karl T. Kelsey, Alan R. Schned, Eben M. Pendleton, Michael S. Zens, Margaret R. Karagas, and Angeline S. Andrew. 2013. Body mass and smoking are modifiable risk factors for recurrent bladder cancer. Cancer.   doi:10.1002/cncr.28394  
2012
  • Andrew, Angeline S., Ting Hu, Jian Gu, Jiang Gui, Yuanqing Ye, Carmen J. Marsit, Karl T. Kelsey, Alan R. Schned, Sam A. Tanyos, Eben M. Pendleton, Rebecca A. Mason, Elaine V. Morlock, Michael S. Zens, Zhongze Li, Jason H. Moore, Xifeng Wu, and Margaret R. Karagas. 2012. HSD3B and gene-gene interactions in a pathway-based analysis of genetic susceptibility to bladder cancer. PLoS ONE.   7(12):e51301. doi:10.1371/journal.pone.0051301  
  • Davis, Matthew A., Todd A. MacKenzie, Kathyrn L. Cottingham, Diane Gilbert-Diamond, Tracy Punshon, and Margaret R. Karagas. 2012. Rice consumption and urinary arsenic concentrations in U.S. children. Environmental Health Perspectives. 1290:1418-1424.
  • Gruber, Joann F., Margaret R. Karagas, Diane Gilbert-Diamond, Pamela J. Bagley, Michael S. Zens, Vicki Sayarath, Tracy Punshon, Joe B. Morrissey, and Kathyrn L. Cottingham. 2012. Associations between toenail arsenic concentration and dietary factors in a New Hampshire population. Nutrition Journal. 11:45. doi:10.1186/1475-2891-11-45  
  • Jackson, Brian P., Vivien F. Taylor, Tracy Punshon, Kathyrn L. Cottingham, and Margaret R. Karagas. 2012. Arsenic, organic foods, and brown rice syrup. Environmental Health Perspectives. 120:623-626. doi:10.1289/ehp.1104619  
  • Karagas, Margaret R., Angeline S. Andrew, Heather H. Nelson, Z. Li, Tracy Punshon, Alan R. Schned, Carmen J. Marsit, J Steven Morris, Jason H. Moore, A.L. Tyler, Diane Gilbert-Diamond, Mary L. Guerinot, and Karl T. Kelsey. 2012. SLC39A2 and FSIP1 polymorphisms as potential modifiers of arsenic-related bladder cancer. Human Genetics.   131:453-461. doi:10.1007/s00439-011-1090-x  
  • Karagas, Margaret R., Anna L. Choi, Emily Oken, Milena Horvat, Rita Schoeny, Elizabeth Kamai, Whitney Cowell, Philippe Grandjean, and Susan A. Korrick. 2012. Evidence on the Human Health Effects of Low-Level Methylmercury Exposure. Environmental Health Perspectives. 120:799-806. doi:10.1289/ehp.1104494  
  • Karagas, Margaret R., Elsie M. Sunderland, Aria Amirbahman, Neil M. Burgess, John Dalziel, Gareth Harding, Stephen H. Jones, Elizabeth Kamai, Xun Shi, and Celia Y. Chen. 2012. Mercury sources and fate in the Gulf of Maine. Environmental Research.   119:27-41. doi:10.1016/j.envres.2012.03.011  
  • Lesseur, Corina, Diane Gilbert-Diamond, Angeline S. Andrew, R.M. Ekstrom, Z. Li, Karl T. Kelsey, Carmen J. Marsit, and Margaret R. Karagas. 2012. A case-control study of polymorphisms in zenobiotic and arsenic metabolism genes and arsenic-related bladder cancer in New Hampshire. Toxicology Letters.   210:100-106. doi:10.1016/j.toxlet.2012.01.015  
  • Madan, J.C., Devin C. Koestler, Bruce A. Stanton, L. Davidson, L.A. Moulton, M.L. Housman, Jason H. Moore, M.F. Guill, Hilary G. Morrison, Mitchell L. Sogin, Thomas H. Hampton, Margaret R. Karagas, P.E. Palumbo, J.A. Foster, P.L. Hibberd, and George A. O'Toole. 2012. Serial analysis of the gut and respiratory microbiome in cystic fibrosis in infancy: Interactions between intestinal and respiratory tracts and impact of nutritional exposures. mBio. 3(4):e00251-12. doi:10.1128/mBio.00251-12  
  • Oken, Emily, Anna L. Choi, Margaret R. Karagas, Koenraad Marien, Christoph M. Rheinberger, Rita Schoeny, Elsie M. Sunderland, and Susan A. Korrick. 2012. Which Fish Should I Eat? Perspectives Influencing Fish Consumption Choices. Environmental Health Perspectives. 120(6):790-798. doi:10.1289/ehp.1104500  
  • Sloan, Chantel D., Angeline S. Andrew, Joann F. Gruber, K.M. Mwenda, Jason H. Moore, Tracy Onega, Margaret R. Karagas, Xianglin Shi, and Eric J. Duell. 2012. Indoor and outdoor air pollution and lung cancer in New Hampshire and Vermont. Toxicology and Environmental Chemistry. 94:605-615. doi:10.1080/02772248.2012.659930  
2011
  • Brinkman, Maree T., Margaret R. Karagas, Michael S. Zens, Alan R. Schned, Raoul C. Reulen, and Maurice P. Zeegers. 2011. Intake of alpha-linolenic acid and other fatty acids in relation to the risk of bladder cancer: results from the New Hampshire case-control study. British Journal of Nutrition.   106(7):1070-1077. doi:10.1017/s0007114511001346   (Completed with ARRA Funds)
  • Cowper-Sallari, Richard, Michael D. Cole, Margaret R. Karagas, Mathieu Lupien, and Jason H. Moore. 2011. Layers of epistasis: genome-wide regulatory networks and network approaches to genome-wide association studies. Wiley Interdisciplinary Reviews: Systems Biology and Medicine.   3:513-526. doi:10.1002/wsbm.132  
  • Dietrich, K., Eugene Demidenko, Alan R. Schned, Michael S. Zens, John A. Heaney, and Margaret R. Karagas. 2011. Parity, early menopause and the incidence of bladder cancer in women: A case-control study and meta-analysis. European Journal of Cancer.   47(4):592-599. doi:10.1016/j.ejca.2010.10.007   (Completed with ARRA Funds)
  • Fan, R., M. Zhong, Shirley Wang, Y. Zhang, Angeline S. Andrew, Margaret R. Karagas, H. Chen, M. Xiong, Jason H. Moore, and Christopher I. Amos. 2011. Entropy-based information gain approaches to detect and to characterize gene-gene and gene-environment interactions/correlations of complex diseases. Genetic Epidemiology. 35(7):706-721. doi:10.1002/gepi.20621  
  • Gilbert-Diamond, Diane, Kathyrn L. Cottingham, Joann F. Gruber, Tracy Punshon, Vicki Sayarath, A Jay Gandolfi, Emily Baker, Brian P. Jackson, Carol L. Folt, and Margaret R. Karagas. 2011. Rice consumption contributes to arsenic exposure in US women. Proceedings of the National Academy of Sciences of the United States of America (PNAS).   108(51):20656-20660. doi:10.1073/pnas.1109127108  
  • Gui, Jiang, Angeline S. Andrew, Peter C. Andrews, Heather Nelson, Karl T. Kelsey, Margaret R. Karagas, and Jason H. Moore. 2011. A robust multifactor dimensionality reduction method for detecting gene-gene interactions with application to the genetic analysis of bladder cancer susceptibility. Annals of Human Genetics.   75(1):20-28. doi:10.1111/j.1469-1809.2010.00624.x   (Completed with ARRA Funds)
  • Gui, Jiang, Jason H. Moore, Karl T. Kelsey, Carmen J. Marsit, Margaret R. Karagas, and Angeline S. Andrew. 2011. A novel survival multifactor dimensionality reduction method for detecting gene-gene interactions with application to bladder cancer prognosis. Human Genetics.   129(1):101-110. doi:10.1007/s00439-010-0905-5   (Completed with ARRA Funds)
  • Hu, Ting, Nicholas A. Sinnott-Armstrong, Jeff W. Kiralis, Angeline S. Andrew, Margaret R. Karagas, and Jason H. Moore. 2011. Characterizing genetic interactions in human disease association studies using statistical epistasis networks. BMC Bioinformatics. 12:364. doi:10.1186/1471-2105-12-364   (Completed with ARRA Funds)
  • Koutros, S., Debra T. Silverman, Dalsu Baris, Shelia H. Zahm, L.M. Morton, Joanne S. Colt, D.W. Hein, Lee E. Moore, Alison Johnson, Molly Schwenn, S.S. Cherala, Alan R. Schned, M.A. Doll, Nathaniel Rothman, and Margaret R. Karagas. 2011. Hair dye use and risk of bladder cancer in the New England bladder cancer study. International Journal of Cancer.   129:2894-2904. doi:10.1002/ijc.26245  
  • Langevin, Scott M., E. Andrés Houseman, Brock C. Christensen, John K. Wiencke, Heather H. Nelson, Margaret R. Karagas, Carmen J. Marsit, and Karl T. Kelsey. 2011. The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood. Epigenetics. 6:908-919. doi:10.4161/epi.6.7.16431   (Completed with ARRA Funds)
  • Linos, Athena, Athanassios Petralias, Costas A. Christophi, Eleni Christoforidou, Paraskevi Kouroutou, Melina Stoltidis, Afroditi Veloudaki, Evangelia Tzala, Konstantinos Makris, and Margaret R. Karagas. 2011. Oral ingestion of hexavalent chromium through drinking water and cancer mortality in an industrial area of Greece - An ecological study. Environmental Health.   10:50. doi:10.1186/1476-069X-10-50  
  • MacKenzie, Todd A., Michael S. Zens, Assiamira Ferrara, Alan R. Schned, and Margaret R. Karagas. 2011. Diabetes and risk of bladder cancer: Evidence from a case-control study in New England. Cancer.   117(7):1552-1556. doi:10.1002/cncr.25641   (Completed with ARRA Funds)
  • Marsit, Carmen J., Devin C. Koestler, Brock C. Christensen, Margaret R. Karagas, E. Andrés Houseman, and Karl T. Kelsey. 2011. DNA Methylation Array Analysis Identifies Profiles of Blood-Derived DNA Methylation Associated With Bladder Cancer. Journal of Clinical Oncology.   29(9):1133-1139. doi:10.1200/JCO.2010.31.3577   (Completed with ARRA Funds)
  • Nuckols, J.R., Laura E B. Freeman, Jay H. Lubin, Matthew S. Airola, Dalsu Baris, Joseph D. Ayotte, Anne Taylor, Christopher Paulu, Margaret R. Karagas, Joanne S. Colt, M. Ward, An-Tsun Huang, William Bress, Sai Cherala, and Kenneth P. Cantor. 2011. Estimating water supply arsenic levels in the new England bladder cancer study. Environmental Health Perspectives. 199(9):doi:doi:10.1289/ehp.1002345   (Completed with ARRA Funds)
  • Wilhelm-Benartzi, Charlotte, Brock C. Christensen, Devin C. Koestler, E. Andrés Houseman, Alan R. Schned, Margaret R. Karagas, Karl T. Kelsey, and Carmen J. Marsit. 2011. Association of secondhand smoke exposures with DNA methylation in bladder carcinomas. Cancer Causes & Control. 22:1205-1213. doi:10.1007/s10552-011-9788-6  
  • Wilhelm-Benartzi, Charlotte, Brock C. Christensen, Devin C. Koestler, E. Andrés Houseman, Alan R. Schned, Margaret R. Karagas, Karl T. Kelsey, Carmen J. Marsit, and John K. Wiencke. 2011. Association of second hand smoke exposures with DNA methylation in bladder cancer cases. Cancer Causes & Control. 22(8):1205-1213. doi:10.1007/s10552-011-9788-6   (Completed with ARRA Funds)
2010
  • Christensen, Brock C., A. Smith, Shichun Zheng, Devin C. Koestler, E Andres Houseman, Carmen J. Marsit, Joseph L. Wiemels, Heather Nelson, Margaret R. Karagas, Margaret R. Wrensch, Karl T. Kelsey, and John K. Wiencke. 2010. DNA Methylation, Isocitrate Dehydrogenase Mutation, and Survival in Glioma. Journal of the National Cancer Institute.   103:143-153.
  • Fei, Dennis L., Hua Li, Courtney D. Kozul-Horvath, Kendall E. Black, Samer Singh, Julie A. Gosse, James DiRenzo, Kathleen A. Martin, Baolin Wang, Joshua W. Hamilton, Margaret R. Karagas, and David J. Robbins. 2010. Activation of hedgehog signaling by the environmental toxicant arsenic may contribute to the etiology of arsenic-induced tumors. Cancer Research.   70(5):1981-1988. doi:10.1158/0008-5472.can-09-2898  
  • Greene, Casey S., Daniel S. Himmelstein, Heather H. Nelson, Karl T. Kelsey, Scott M. Williams, Angeline S. Andrew, Margaret R. Karagas, and Jason H. Moore. 2010. Enabling personal genomics with an explicit test of epistasis. Pacific Symposium on Biocomputing. 327-36. doi:10.1142/9789814295291_0035  
  • Gui, Jiang, Angeline S. Andrew, Peter C. Andrews, H.A. Nelson, Karl T. Kelsey, Margaret R. Karagas, and Jason H. Moore. 2010. A simple and computationally efficient sampling approach to covariate adjustment for multifactor dimensionality reduction analysis of epistasis. Human Heredity. 70:219-225. doi:10.1159/000319175  
  • Karagas, Margaret R. 2010. Arsenic-related mortality in Bangladesh. The Lancet.   376(9737):213-214. doi:10.1016/S0140-6736(10)61002-1   (Completed with ARRA Funds)
  • Koestler, Devin C., Carmen J. Marsit, Brock C. Christensen, Margaret R. Karagas, Raphael Bueno, David J. Sugarbaker, Karl T. Kelsey, and E. Andrés Houseman. 2010. Semi-supervised recursively partitioned mixture models for identifying cancer subtypes. Bioinformatics.   26(20):2578-2585. doi:10.1093/bioinformatics/btq470   (Completed with ARRA Funds)
  • Kwong, Ryan C., Margaret R. Karagas, Karl T. Kelsey, Rebecca A. Mason, Sam A. Tanyos, Alan R. Schned, Carmen J. Marsit, and Angeline S. Andrew. 2010. Arsenic exposure predicts bladder cancer survival in a US population. World Journal of Urology.   28:487-92. doi:10.1007/s00345-009-0477-y   (Completed with ARRA Funds)
  • Marsit, Carmen J., E. Andrés Houseman, Brock C. Christensen, Luc A. Gagne, Margaret R. Wrensch, Heather H. Nelson, Joseph L. Wiemels, Shichun Zheng, John K. Wiencke, Angeline S. Andrew, Alan R. Schned, Margaret R. Karagas, and Karl T. Kelsey. 2010. Identification of Methylated Genes Associated with Aggressive Bladder Cancer. PLoS ONE.   5:e12334. doi:10.1371/journal.pone.0012334  
  • Moore, Lee E., Dalsu Baris, Jonine D. Figueroa, Montserrat Garcia-Closas, Molly Schwenn, Alison Johnson, Jay H. Lubin, D.W. Hein, C.L. Dagnall, Joanne S. Colt, M. Kida, M.A. Jones, Alan R. Schned, S.S. Cherala, Stephen J. Chanock, Kenneth P. Cantor, Debra T. Silverman, Nathaniel Rothman, and Margaret R. Karagas. 2010. GSTM1 null and NAT2 slow acetylation genotypes, smoking intensity and bladder cancer risk: results from the New England bladder cancer study and NAT2 meta-analysis. Carcinogenesis.   32:182-9. doi:10.1093/carcin/bgq223  
  • Rothman, Nathaniel, Montserrat Garcia-Closas, Nilanjan Chatterjee, Nuria Malats, Xifeng Wu, Jonine D. Figueroa, Francisco X. Real, David Van Den Berg, Giuseppe Matullo, Dalsu Baris, Michael Thun, Lambertus A. Kiemeney, Paolo Vineis, Immaculata De Vivo, Demetrius Albanes, Mark P. Purdue, Thorunn Rafnar, Michelle AT Hildebrandt, Anne E. Kiltie, Olivier Cussenot, Klaus Golka, Rajiv Kumar, Jack A. Taylor, Jose I. Mayordomo, Kevin B. Jacobs, Manolis Kogevinas, Amy Hutchinson, Zhaoming Wang, Yi-Ping Fu, Ludmila Prokunina-Olsson, Laurie Burdett, Meredith Yeager, William Wheeler, Adonina Tardon, Consol Serra, Alfredo Carrato, Reina Garcia-Closas, Josep Lloreta, Alison Johnson, Molly Schwenn, Margaret R. Karagas, Alan R. Schned, Gerald Andriole, Robert Grubb, Amanda Black, Eric J. Jacobs, W.R. Diver, Susan M. Gapstur, Stephanie J. Weinstein, Jarmo Virtamo, Victoria K. Cortessis, Manuela Gago-Dominguez, Malcolm C. Pike, Mariana C. Stern, Jian-Min Yuan, David J. Hunter, Monica McGrath, Colin P. Dinney, Bogdan Czerniak, Meng Chen, Hushan Yang, Sita H. Vermeulen, Katja K. Aben, J Alfred Witjes, Remco R. Makkinje, Patrick Sulem, Soren Besenbacher, Kari Stefansson, Elio Riboli, Paul Brennan, Salvatore Panico, Carmen Navarro, Naomi E. Allen, H.B. Bueno-de-Mesquita, Dimitrios Trichopoulos, Neil Caporaso, Maria Teresa Landi, Federico Canzian, Borje Ljungberg, Anne Tjonneland, Francoise Clavel-Chapelon, David T. Bishop, Mark TW Teo, Margaret A. Knowles, Simonetta Guarrera, Silvia Polidoro, Fulvio Ricceri, Carlotta Sacerdote, Alessandra Allione, Geraldine Cancel-Tassin, Silvia Selinski, Jan G. Hengstler, Holger Dietrich, Tony Fletcher, Peter Rudnai, Eugen Gurzau, Kvetoslava Koppova, Sophia CE Bolick, Ashley Godfrey, Zongli Xu, Jose I. Sanz-Velez, Maria D. Garcia-Prats, Manuel Sanchez, Gabriel Valdivia, Stefano Porru, Simone Benhamou, Robert N. Hoover, Joseph F. Fraumeni, Debra T. Silverman, and Stephen J. Chanock. 2010. A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Nature Genetics.   42(11):978-984. doi:10.1038/ng.687  
  • Wilhelm, Charlotte S., Karl T. Kelsey, Rondi A. Butler, Silvia Plaza, Luc A. Gagne, Michael S. Zens, Angeline S. Andrew, Steven Morris, Heather H. Nelson, Alan R. Schned, Margaret R. Karagas, and Carmen J. Marsit. 2010. Implications of LINE1 methylation for bladder cancer risk in women. Clinical Cancer Research.   16:1682-1689. doi:10.1158/1078-0432.ccr-09-2983  
  • Wilhelm-Benartzi, Charlotte, Devin C. Koestler, Brock C. Christensen, John K. Wiencke, Alan R. Schned, Margaret R. Karagas, Karl T. Kelsey, Carmen J. Marsit, and E Andres Houseman. 2010. DNA methylation profiles delineate etiologic heterogeneity and clinically important subgroups of bladder cancer. Carcinogenesis.   31:1972-1976. doi:10.1093/carcin/bgq178   (Completed with ARRA Funds)
2009
  • Andrew, Angeline S., Jiang Gui, Arthur Sanderson, Rebecca A. Mason, Elaine V. Morlock, Alan R. Schned, Karl Kelsey, Carmen J. Marsit, Jason H. Moore, and Margaret R. Karagas. 2009. Bladder cancer SNP panel predicts susceptibility and survival. Human Genetics.   125(5-6):527-539. doi:10.1007/s00439-009-0645-6  
  • Andrew, Angeline S., Rebecca A. Mason, Karl Kelsey, Alan R. Schned, Carmen J. Marsit, Heather H. Nelson, and Margaret R. Karagas. 2009. DNA repair genotype interacts with arsenic exposure to increase bladder cancer risk. Toxicology Letters.   187(1):10-14. doi:10.1016/j.toxlet.2009.01.013  
  • Baris, Dalsu, Margaret R. Karagas, Castine Verrill, Alison Johnson, Angeline S. Andrew, Carmen J. Marsit, Joanne S. Colt, Sai Cherala, Claudine Samanic, Richard Waddell, Kenneth P. Cantor, Alan R. Schned, Nathaniel Rothman, Jay H. Lubin, Joseph F. Fraumeni, Robert N. Hoover, Karl T. Kelsey, Debra T. Silverman, and Molly Schwenn. 2009. A case-control study of smoking and bladder cancer risk: Emergent patterns over time. Journal of the National Cancer Institute.   101(22):1553-61. doi:10.1093/jnci/djp361  
  • Brinkman, Maree T., Margaret R. Karagas, Michael S. Zens, Alan R. Schned, Raoul C. Reulen, and Maurice P. Zeegers. 2009. Minerals and vitamins and the risk of bladder cancer: results from the New Hampshire Study. Cancer Causes & Control.   doi:10.1007/s10552-009-9490-0  
  • Christensen, Brock C., E. Andrés Houseman, Carmen J. Marsit, Shichun Zheng, Margaret R. Wrensch, Joseph L. Wiemels, Heather H. Nelson, Margaret R. Karagas, J. Padbury, Raphael Bueno, David J. Sugarbaker, Ru-Fang Yeh, John K. Wiencke, and Karl T. Kelsey. 2009. Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genetics.   5(8):e1000602. doi:10.1371/journal.pgen.1000602  
  • Dietrich, K., Alan R. Schned, J. Fortuny, John A. Heaney, Carmen J. Marsit, Karl T. Kelsey, and Margaret R. Karagas. 2009. Glucocorticoid therapy and risk of bladder cancer. British Journal of Cancer.   101(8):1316-20. doi:10.1038/sj.bjc.6605314  
  • Heck, Julia E., Angeline S. Andrew, Tracy Onega, James R. Rigas, Brian P. Jackson, Margaret R. Karagas, and Eric J. Duell. 2009. Lung cancer in a U.S. population with low to moderate arsenic exposure. Environmental Health Perspectives. 117(11):1718-23.
  • Kelsey, Karl T., Alan R. Schned, J Steven Morris, Angeline S. Andrew, Margaret R. Karagas, and Kristin Wallace. 2009. Selenium and risk of bladder cancer: a population-based case-control study. Cancer Prevention Research.   2(1):70-73. doi:10.1158/1940-6207.CAPR-08-0046  
  • Mason, Rebecca A., Elaine V. Morlock, Margaret R. Karagas, Karl T. Kelsey, Carmen J. Marsit, Alan R. Schned, and Angeline S. Andrew. 2009. EGFR pathway polymorphisms in bladder cancer susceptibility and prognosis. Carcinogenesis.   30(7):1155-1160. doi:10.1093/carcin/bgp077  
  • Sloan, Chantel D., Angeline S. Andrew, Eric J. Duell, Scott M. Williams, Margaret R. Karagas, and Jason H. Moore. 2009. Genetic population structure analysis in New Hampshire reveals Eastern European ancestry. PLoS ONE.   4(9):e6928. doi:10.1371/journal.pone.0006928  
  • Stern, Mariana C., Jie Lin, Jonine D. Figueroa, Karl T. Kelsey, Anne E. Kiltie, Jian-Min Yuan, Giuseppe Matullo, Tony Fletcher, Simone Benhamou, Jack A. Taylor, Donatella Placidi, Zuo-feng Zhang, Gunnar Steineck, Nathaniel Rothman, Manolis Kogevinas, Debra T. Silverman, Nuria Malats, Stephen J. Chanock, Xifeng Wu, Margaret R. Karagas, Angeline S. Andrew, Heather H. Nelson, David T. Bishop, Sei Chung Sak, Ananya Choudhury, Jennifer H. Barrett, Faye Elliot, Roman Corral, Amit D. Joshi, Manuela Gago-Dominguez, Victoria K. Cortessis, Yu-Tang Gao, Yong-Bing Xiang, Paolo Vineis, Carlotta Sacerdote, Simonetta Guarrera, Silvia Polidoro, Alessandra Allione, Eugen Gurzau, Kvetoslava Koppova, Rajiv Kumar, Peter Rudnai, Stefano Porru, Angela Carta, Marcello Campagna, Cecilia Arici, Sung Shim Park, and Montserrat Garcia-Closas. 2009. Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: Findings from the International Consortium of Bladder Cancer. Cancer Research.   69(17):6857-64. doi:10.1158/0008-5472.CAN-09-1091  
  • Wu, Xifeng, Yuanqing Ye, Lambertus A. Kiemeney, Patrick Sulem, Thorunn Rafnar, Giuseppe Matullo, Daniela Seminara, Teruhiko Yoshida, Norihisa Saeki, Angeline S. Andrew, Colin P. Dinney, Bogdan Czerniak, Zuo-feng Zhang, Anne E. Kiltie, D Timothy Bishop, Paolo Vineis, Stefano Porru, Frank Buntinx, Eliane Kellen, Maurice P. Zeegers, Rajiv Kumar, Peter Rudnai, Eugen Gurzau, Kvetoslava Koppova, Jose Ignacio Mayordomo, Manuel Sanchez, Berta Saez, A. Lindblom, Petra de Verdier,, Gunnar Steineck, Gordan B. Mills, Alan R. Schned, Simonetta Guarrera, Silvia Polidoro, Shen-Chih Chang, Jie Lin, David W. Chang, Katherine S. Hale, Tadeusz Majewski, H.B. Grossman, Steinunn Thorlacius, Unnur Thorsteinsdottir, Katja K. Aben, J Alfred Witjes, Kari Stefansson, Christopher I. Amos, Margaret R. Karagas, and Jian Gu. 2009. Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer. Nature Genetics.   41(9):991-995. doi:10.1038/ng.421  
2008
  • Andrew, Angeline S., David A. Jewell, Rebecca A. Mason, Michael L. Whitfield, Jason H. Moore, and Margaret R. Karagas. 2008. Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. population. Environmental Health Perspectives. 116(4):524-531. doi:10.1289/ehp.10861  
  • Houseman, E.Andrés, Brock C. Christensen, Ru-Fang Yeh, Carmen J. Marsit, Margaret R. Karagas, Margaret R. Wrensch, Heather H. Nelson, Joseph L. Wiemels, Shichun Zheng, John K. Wiencke, and Karl T. Kelsey. 2008. Model-based clustering of DNA methylation array data: A recursive-partitioning algorithm for high-dimensional data arising as a mixture of beta distributions. BMC Biochemistry.   9:365. doi:10.1186/1471-2105-9-365  
  • Moore, Jason H., Margaret R. Karagas, and Angeline S. Andrew. 2008. Analysis of Complex Datasets. Chapter 16 in: Molecular Epidemiology of Chronic Diseases. John Wiley & Sons Ltd, West Sussex, pp.207-222.
  • Moore, Jason H., Margaret R. Karagas, and Angeline S. Andrew. 2008. Novel analytical methods for association studies. Chapter 12 in: Molecular Epidemiology: Applications in Cancer and Other Human Diseases. nforma Health Care, pp.169-187.
  • Schned, Alan R., Angeline S. Andrew, Carmen J. Marsit, Karl T. Kelsey, Michael S. Zens, and Margaret R. Karagas. 2008. Histological classification and stage of newly diagnosed bladder cancer in a population-based study from the Northeastern United States. Scandinavian Journal of Urology and Nephrology.   42(3):237-42.
2007
  • Andrew, Angeline S., Margaret R. Karagas, Heather H. Nelson, Simonetta Guarrera, Silvia Polidoro, Sara Gamberini, Carlotta Sacerdote, Jason H. Moore, Karl T. Kelsey, Eugene Demidenko, Paolo Vineis, and Giuseppe Matullo. 2007. DNA repair polymorphisms modify bladder cancer risk: A multi-factor analytic strategy. Cancer Epidemiology Biomarkers & Prevention.   65(2):105-118. doi:10.1159/000108942  
2006
  • Andrew, Angeline S., Jefferey L. Burgess, Maria Mercedes Meza, Eugene Demidenko, Mary G. Waugh, Joshua W. Hamilton, and Margaret R. Karagas. 2006. Arsenic exposure is associated with decreased DNA repair in vitro and in individuals exposed to drinking water arsenic. Environmental Health Perspectives. 114:1193-1198. doi:10.1289/ehp.9008  
  • Andrew, Angeline S., Heather H. Nelson, Karl T. Kelsey, Jason H. Moore, Alexis C. Meng, Daniel P. Casella, Tor Devin Tosteson, Alan R. Schned, and Margaret R. Karagas. 2006. Concordance of multiple analytical approaches demonstrates a complex relationship between DNA repair gene SNPs, smoking and bladder cancer susceptibility. Carcinogenesis.   27(5):1030-1037.
  • Ayotte, Joseph D., Dalsu Baris, Kenneth P. Cantor, Joanne S. Colt, Gilpin R. Robinson, Jay H. Lubin, Margaret R. Karagas, Robert N. Hoover, Joseph F. Fraumeni, and Debra T. Silverman. 2006. Bladder cancer mortality and private well use in New England: an ecological study. Journal of Epidemiology and Community Health.   60:168-172. doi:10.1136/jech.2005.038620  
  • Ayotte, Joseph D., Bernard T. Nolan, John R. Nuckols, Kenneth P. Cantor, Gilpin R. Robinson, Dalsu Baris, Laura Hayes, Margaret R. Karagas, William Bress, Debra T. Silverman, and Jay H. Lubin. 2006. Modeling the probability of arsenic in groundwater in New England as a tool for exposure assessment. Environmental Science & Technology.   40(11):3578-85. doi:10.1021/es051972f  
  • Karagas, Margaret R., Martin A. Weinstock, and Heather H. Nelson. 2006. Keratinocyte Carcinomas. Chapter 64 in: Cancer Epidemiology and Prevention   . Oxford University Press, New York, NY.
  • Manuguerra, M., F. Saletta, Margaret R. Karagas, M. Berwick, F. Veglia, Paolo Vineis, and G. Matullo. 2006. XRCC3 and XPD/ERCC2 single nucleotide polymorphisms and the risk of cancer: a HuGE review. American Journal of Epidemiology.   164(4):297-302.
  • Marsit, Carmen J., E. Andrés Houseman, Karen Eddy, Raphael Bueno, David J. Sugarbaker, Heather H. Nelson, Margaret R. Karagas, Karl T. Kelsey, and Brock C. Christensen. 2006. Examination of a CpG island methylator phenotype and implications of methylation profiles in solid tumors. Cancer Research.   66(21):10621-9.
  • Marsit, Carmen J., Margaret R. Karagas, Hadi Danaee, Mei Liu, Angeline S. Andrew, Alan R. Schned, Heather H. Nelson, and Karl T. Kelsey. 2006. Carcinogen exposure and gene promoter hypermethylation in bladder cancer. Carcinogenesis.   27(1):112-116.
  • Marsit, Carmen J., Margaret R. Karagas, Alan R. Schned, and Karl T. Kelsey. 2006. Carcinogen exposure and epigenetic silencing in bladder cancer. Annals of the New York Academy of Sciences.   1076:810-21.
  • Sturup, Stefan, Carol L. Folt, Margaret R. Karagas, Judy R. Rees, and Celia Y. Chen. 2006. Toenail mercury and dietary fish consumption. Journal of Exposure Analysis and Environmental Epidemiology.   17:25-30. doi:10.1038/sj.jes.7500516  
2005
  • Hirao, Shuya, Tomoko Hirao, Yoko Hirao, Carmen J. Marsit, Alan R. Schned, Tara Devi-Ashok, Heather H. Nelson, Angeline S. Andrew, Margaret R. Karagas, and Karl T. Kelsey. 2005. Loss of heterozygosity on chromosome 9q and p53 alterations in human bladder cancer. Cancer.   104(9):1918-1923.
  • Karagas, Margaret R., Sunyeong Park, Heather H. Nelson, Angeline S. Andrew, Leila A. Mott, Alan R. Schned, and Karl T. Kelsey. 2005. Methylenetetrahydrofolate reductase (MTHFR) variants and bladder cancer: A population-based case-control study. International Journal of Hygiene and Environmental Health.   208(5):321-327.
  • Karagas, Margaret R., Sunyeong Park, Amy J. Warren, Joshua W. Hamilton, Heather H. Nelson, Leila A. Mott, and Karl T. Kelsey. 2005. Gender, smoking, glutathione-S-transferase variants and bladder cancer incidence: a population-based study. Cancer Letters.   219(1):63-69. doi:10.1016/j.canlet.2004.10.006  
  • Kelsey, Karl T., Tomoko Hirao, Shuya Hirao, Tara Devi-Ashok, Heather H. Nelson, Angeline S. Andrew, Joanne S. Colt, Dalsu Baris, J Steven Morris, Alan R. Schned, and Margaret R. Karagas. 2005. TP53 alterations and patterns of carcinogen exposure in a U.S. population-based study of bladder cancer. International Journal of Cancer.   117(3):370-375.
  • Marsit, Carmen J., Margaret R. Karagas, Angeline S. Andrew, Mei Liu, Hadi Danaee, Alan R. Schned, Heather H. Nelson, and Karl T. Kelsey. 2005. Epigenetic Inactivation of SFRP Genes and TP53 Alteration Act Jointly as Markers of Invasive Bladder Cancer. Cancer Research.   65(16):7081-7085.
2004
  • Andrew, Angeline S., Alan R. Schned, John A. Heaney, and Margaret R. Karagas. 2004. Bladder cancer risk and personal hair dye use. International Journal of Cancer.   109(4):581-586.
  • Carroll, Raymond J., David Ruppert, Tor Devin Tosteson, and Margaret R. Karagas. 2004. Nonlinear and nonparametric regression and instrumental variables. Journal of the American Statistical Association.   99(467):736-750.
  • Colt, Joanne S., Dalsu Baris, Patricia Stewart, Alan R. Schned, John A. Heaney, Leila A. Mott, Debra T. Silverman, and Margaret R. Karagas. 2004. Occupation and bladder cancer risk in a population-based case-control study in New Hampshire. Cancer Causes & Control.   15(8):759-769.
  • Karagas, Margaret R., Tor Devin Tosteson, J Steven Morris, Eugene Demidenko, Leila A. Mott, John A. Heaney, and Alan R. Schned. 2004. Incidence of transitional cell carcinoma of the bladder and arsenic exposure in New Hampshire. Cancer Causes & Control.   15(5):465-472.
  • Kelsey, Karl T., Tomoko Hirao, Alan R. Schned, Shuya Hirao, Tara Devi-Ashok, Heather H. Nelson, Angeline S. Andrew, and Margaret R. Karagas. 2004. A population-based study of immunohistochemical detection of p53 alteration in bladder cancer. British Journal of Cancer.   90(8):1572-1576.
  • Kelsey, Karl T., Sunyeong Park, Heather H. Nelson, and Margaret R. Karagas. 2004. A Population-Based Case-Control Study of the XRCC1 Arg399Gln Polymorphism and Susceptibility to Bladder Cancer. Cancer Epidemiology Biomarkers & Prevention.   13(8):1337-1341.
  • Wickre, Joel B., Carol L. Folt, Stefan Sturup, and Margaret R. Karagas. 2004. Environmental exposure and fingernail analysis of arsenic and mercury in children and adults in a Nicaraguan gold mining community. Archives of Environmental Health.   59(8):400-409.
2003
  • Andrew, Angeline S., Margaret R. Karagas, and Joshua W. Hamilton. 2003. Decreased DNA repair gene expression among individuals exposed to arsenic in United States drinking water. International Journal of Cancer.   104(3):263-268.
  • Andrew, Angeline S., Margaret R. Karagas, L. Klei, and Joshua W. Hamilton. 2003. Drinking water arsenic exposure is associated with decreased DNA repair gene expression. Toxicological Sciences.   72(S1):184.
  • Tosteson, Tor Devin, Jeffery S. Buzas, Eugene Demidenko, and Margaret R. Karagas. 2003. Power and sample size calculations for generalized regression models with covariate measurement error. Statistics in Medicine.   22(7):1069-1082.
2002
  • Andrew, Angeline S., Margaret R. Karagas, Alan R. Schned, and Joshua W. Hamilton. 2002. Decreased expression of DNA repair genes ERCC1, XPF, and XPB, but not XPG or XPA among individuals exposed to arsenic in drinking water. In: Proceedings of the 93rd Annual Meeting of the American Association for Cancer Research, April 6-10, 2002. San Francisco, CA.
  • Andrew, Angeline S., Leila A. Mott, John A. Heaney, Alan R. Schned, and Margaret R. Karagas. 2002. Bladder cancer risk and personal hair dye use in women. In: Proceedings of the 93rd Annual Meeting of the American Association for Cancer Research, April 6-10, 2002. San Francisco, CA.
  • Colt, Joanne S., Dalsu Baris, S.F. Clark, Joseph D. Ayotte, M. Ward, J.R. Nuckols, Kenneth P. Cantor, Debra T. Silverman, and Margaret R. Karagas. 2002. Sampling private wells at past homes to estimate arsenic exposure: a methodologic study in New England. Journal of Exposure Analysis and Environmental Epidemiology.   12(5):329-334.
  • Danaee, Hadi, Heather H. Nelson, Margaret R. Karagas, Alan R. Schned, Tara Devi-Ashok, Tomoko Hirao, Ann E. Perry, and Karl T. Kelsey. 2002. Microsatellite instability at tetranucleotide repeats in skin and bladder cancer. Oncogene.   21(32):4894-4899.
  • Danaee, Hadi, Heather H. Nelson, Margaret R. Karagas, Alan R. Schned, Tara Devi-Ashok, Tomoko Hirao, Ann E. Perry, and Karl T. Kelsey. 2002. Microsatellite instability at tetranucleotide repeats in skin and bladder cancer. In: Proceedings of the 93rd Annual Meeting of the American Association for Cancer Research, April 6-10, 2002. San Francisco, CA.
  • Karagas, Margaret R., H.A. Nelson, Karl T. Kelsey, S. Morris, Joel D. Blum, Tor Devin Tosteson, M. Carey, and X Chris Le. 2002. Urinary Arsenic species in relation to drinking water and toenail arsenic concentrations and genetic polymorphisms in GSTM1 in New Hampshire. In: Biomarkers of Environmentally Associated Disease: Technologies, Concepts, and Perspectives   . CRC Press Company, Boca Raton, FL.
  • Karagas, Margaret R., H.A. Nelson, Karl T. Kelsey, S. Morris, Joel D. Blum, Tor Devin Tosteson, M. Carey, and X Chris Le. 2002. Urinary arsenic species in relation to drinking water and toenail arsenic concentrations and genetic polymorphisms in GSTM1 in New Hampshire. Proceedings in Nucleic Research. 17:251-261.
  • Karagas, Margaret R., Therese A. Stukel, and Tor Devin Tosteson. 2002. Assessment of cancer risk and environmental levels of arsenic in New Hampshire. International Journal of Hygiene and Environmental Health.   205(1-2):85-94.
  • Schned, Alan R., Margaret R. Karagas, and Karl T. Kelsey. 2002. Prevalence of bladder tumour types in a non-selected patient Population, classified according tothe World Health Organization/International Society of Urologic Pathologists(WHO/ISUP) System. Histopathology. 41(S1):52-53.
2001
  • Karagas, Margaret R., X Chris Le, S. Morris, Joel D. Blum, Xiufen Lu, Vickie L. Spate, M. Carey, Virginia Stannard, Bjoern Klaue, and Tor Devin Tosteson. 2001. Markers of low level arsenic exposure for evaluating human cancer risks in a U.S. population. International Journal of Occupational Medicine and Environmental Health. 14(2):171-175.
  • Karagas, Margaret R., Therese A. Stukel, J Steven Morris, Tor Devin Tosteson, Steven K. Spencer, and E. Robert Greenberg. 2001. Skin cancer risk in relation to toenail arsenic concentrations in a US population-based case-control study. American Journal of Epidemiology.   153(6):559-565.
  • Park, S., Margaret R. Karagas, Heather H. Nelson, Leila A. Mott, Kali M. Bronson, and Karl T. Kelsey. 2001. X-ray repair cross-complementing gene 1 (XRCC1) polymorphisms and the risk of bladder cancer. In: Proceedings of the American Association for Cancer Research Annual Meeting, 2001.
2000
  • Karagas, Margaret R., Tor Devin Tosteson, Joel D. Blum, Bjoern Klaue, Julia E. Weiss, Virginia Stannard, Vickie L. Spate, and J Steven Morris. 2000. Measurement of low levels of arsenic exposure: a comparison of water and toenail concentrations. American Journal of Epidemiology.   152(1):84-90.
  • Tosteson, Tor Devin and Margaret R. Karagas. 2000. Designing an arsenic and bladder cancer case-control study. What sample size is needed to detect the beginning of dose-response?. Metal Ions in Biology and Medicine. 6:28-30.
1999
  • Peters, Stephen C., Joel D. Blum, Bjoern Klaue, and Margaret R. Karagas. 1999. Arsenic occurrence in New Hampshire drinking water. Environmental Science & Technology.   33(9):1328-1333.
1998
  • Karagas, Margaret R., Tor Devin Tosteson, Joel D. Blum, J Steven Morris, John A. Baron, and Bjoern Klaue. 1998. Design of an epidemiological study of drinking water arsenic exposure and cancer risk in a US population. Environmental Health Perspectives. 106Suppl.4:1047-1050.
  • Nichols, T.A., J Steven Morris, M.M. Mason, Vickie L. Spate, Connie K. Baskett, T.P. Cheng, C.J. Tharp, J.A. Scott, T.L. Horsman, A.E. Tawson, Margaret R. Karagas, Virginia Stannard, and J.W. Colbert. 1998. The study of human nails as an intake monitor for arsenic using neutron activation analysis. Journal of Radioanalytical and Nuclear Chemistry.   236(1-2):51-56. doi:10.1007/BF02386317  
1996
  • Karagas, Margaret R., J Steven Morris, Julia E. Weiss, Vickie L. Spate, Connie K. Baskett, and E. Robert Greenberg. 1996. Toenail samples as an indicator of drinking water arsenic exposure. Cancer Epidemiology Biomarkers & Prevention.   5(10):849-852.