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Person Details

Superfund Research Program

Elwood Linney

Duke University
Duke Medical Center
Box 3020 Med Ctr.
Durham, NC 27710
Phone: 919-684-6095
Fax: 919-684-8735
Email:

Projects

• Duke University: Transgenic Fish Facility (2000 - 2005)
• Duke University: Transgenic Fish as Biosensors for Superfund Chemicals (2000-2009)
• Duke University: Vulnerability of the Early Embryonic Nervous System to Chlorpyrifos (2011 - 2016)
• Duke University: Zebrafish as a Detector and Discriminator of Organophosphate (2000-2009)

Research Briefs

• 102 - Multidisciplinary Research to Develop Models to Study the Impacts of Exposure to Chlorpyrifos

Publications

2012

• Roy, N.M., B. Arpie, Elwood Linney, Edward D. Levin, D.T. Cerutti, and J. Lugo. 2012. Brief embryonic strychnine exposure in zebrafish causes long-term adult behavioral impairment with indications of Embryonic synaptic changes. Neurotoxicology and Teratology.   34:587-591. doi:10.1016/j.ntt.2012.08.001  

2011

• Levin, Edward D., Ann Petro, Sue Donerly, Elwood Linney, Damiyon Sledge, and Stephanie Roach. 2011. Persistent behavioral impairment caused by embryonic methylphenidate exposure in zebrafish. Neurotoxicology and Teratology.   33:668-673. doi:10.1016/j.ntt.2011.06.004  
• Sledge, Damiyon, J. Yen, Terrell Morton, Laura Dishaw, Ann Petro, Sue Donerly, Elwood Linney, and Edward D. Levin. 2011. Critical duration of exposure for developmental chlorpyrifos-induced neurobehavioral toxicity. Neurotoxicology and Teratology.   33:742-751. doi:10.1016/j.ntt.2011.06.005  
• Yen, J., Sue Donerly, Edward D. Levin, and Elwood Linney. 2011. Differential acetylcholinesterase inhibition of chlorpyrifos, diazinon and parathion in larval zebrafish. Neurotoxicology and Teratology.   33:735-741. doi:10.1016/j.ntt.2011.10.004  

2010

• Alexeyenko, A., Deena M. Wassenberg, E.K. Lobenhofer, J. Yen, Elwood Linney, E. Sonnhammer, and Joel N. Meyer. 2010. Dynamic zebrafish interactome reveals transcriptional mechanisms of dioxin toxicity. PLoS ONE.   5(5):e10465. doi:10.1371/journal.pone.0010465  
• Powers, C., J. Yen, Elwood Linney, and Fredric J. Seidler. 2010. Silver exposure in developing zebrafish (Danio rerio): Persistent effects on larval behavior and survival. Neurotoxicology and Teratology.   32:391-397. doi:10.1016/j.ntt.2010.01.009  

2009

• Levin, Edward D., Michael Aschner, Ulrike Heberlein, Douglas Ruden, Kathleen A. Welsh-Bohmer, Selena Bartlett, Karen Berger, Lang Chen, Ammon B. Corl, Donnie Eddins, Rachael French, Kathleen M. Hayden, Kirsten Helmcke, Helmut VB Hirsch, Elwood Linney, Greg Lnenicka, Grier P. Page, Debra Possidente, Bernard Possidente, and Annette Kirshner. 2009. Genetic aspects of behavioral neurotoxicology. NeuroToxicology.   30(5):741-53. doi:10.1016/j.neuro.2009.07.014  
• Timme-Laragy, Alicia R., Lindsey A. Van Tiem, Elwood Linney, and Richard T. Di Giulio. 2009. Antioxidant responses and NRF2 in synergistic developmental toxicity of PAHs in zebrafish. Toxicological Sciences.   109(2):217-27. doi:10.1093/toxsci/kfp038  

2007

• Beyer, Richard, Michael Lasarev, Lisiane B. Meira, Valerie S. Palmer, P.K. Ross, Theodor K. Bammler, Blair U. Bradford, Michael L. Cunningham, Greg Higgins, Patrick Hurban, Robert J. Kayton, Oksana Kosyk, Portia A. Vliet, R. Wolfinger, Courtney G. Woods, Jonathan H. Freedman, Elwood Linney, William K. Kaufmann, Terrance J. Kavanagh, Ivan Rusyn, Leona D. Samson, Peter S. Spencer, William A. Suk, and Helmet F. Zarbl. 2007. Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses. Toxicological Sciences.   99(1):326-37.
• Lassiter, Chris S. and Elwood Linney. 2007. Embryonic expression and steroid regulation of brain Aromatase (cyp19a1b) in zebrafish (Danio rerio). Zebrafish.   4(1):49-58.

2006

• Cook, J., Nancy D. Denslow, T. Iguchi, Elwood Linney, A. Miracle, Joseph R. Shaw, Mark R. Viant, and Timothy R. Zacharewski. 2006. "Omics" approaches in the context of environment toxicology. (In: Emerging Molecular and Computational Approaches for Cross-Species Extrapolations). Chapter 1in: Society of Environmental Toxicology and Chemistry (SETAC) Annual Meeting 2006. Washington, DC. pp.1-29.
• Cook, Jon, Nancy D. Denslow, T. Iguchi, Elwood Linney, Ann L. Miracle, Joseph R. Shaw, Mark R. Viant, and Timothy R. Zacharewski. 2006. "Omics" approaches in the context of human and environmental toxicology. Chapter 1 in: Genomic Approaches for Cross-Species Extrapolation in Toxicology. pp.1-25.

2004

• Levin, Edward D., Holly A. Swain, Sue Donerly, and Elwood Linney. 2004. Developmental chlorpyrifos effects on hatchling zebrafish swimming behavior. Neurotoxicology and Teratology.   26(6):719-723.
• Linney, Elwood and Ava J. Udvadia. 2004. Construction and detection of fluorescent germline transgenic zebrafish. Chapter Vol. 254 in: Methods in Molecular Biology, 2004. Humana Press, Inc, Louisville, KY. pp.271-288.
• Linney, Elwood, Lucia Upchurch, and Sue Donerly. 2004. Zebrafish as a neurotoxicological model. Neurotoxicology and Teratology.   26(6):709-718.

2003

• Levin, Edward D., Elizabeth Chrysanthis, Kari Yacsin, and Elwood Linney. 2003. Chlorpyrifos exposure of developing zebrafish: effects on survival and long-term effects on response latency and spatial discrimination. Neurotoxicology and Teratology.   25(1):51-57.
• Linney, Elwood and Ava J. Udvadia. 2003. Construction and detection of fluorescent germ-line transgenic zebrafish. In: Methods in Molecular Medicine. (). Humana Press,
• Udvadia, Ava J. and Elwood Linney. 2003. Windows into development: historic, current, and future perspectives on transgenic zebrafish. Developmental Biology.   256(1):1-17.

2002

• Lassiter, Chris S., B. Kelley, and Elwood Linney. 2002. Genomic structure and embryonic expression of estrogen receptor beta a (ERBa) in zebrafish (Danio rerio). Gene.   292(1-2):141-151.