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National Institute of Environmental Health Sciences

 

Person Details

Superfund Research Program

Rita Loch-Caruso

University of Michigan
Toxicology Program
Ann Arbor, MI 48109-2029
Phone: 734-936-1256
Fax: 734-647-9770
Email:

Projects

Research Briefs

Publications

2014
  • Ferguson, Kelly K., David E. Cantonwine, Luis O. Rivera-Gonzalez, Rita Loch-Caruso, Bhramar Mukherjee, Liza V. Anzalota del Toro, Braulio Jimenez, Antonia M. Calafat, Xiaoyun Ye, Akram N. Alshawabkeh, Jose F. Cordero, and John D. Meeker. 2014. Urinary phthalate metabolite associations with biomarkers of inflammation and oxidative stress across pregnancy in Puerto Rico. Environmental Science & Technology.   48(12):7018-7025. doi:10.1021/es502076j  
  • Park, Hae-Ryung and Rita Loch-Caruso. 2014. Protective effect of nuclear factor E2-related factor 2 on inflammatory cytokine response to brominated diphenyl ether-47 in the HTR-8/SVneo human first trimester extravillous trophoblast cell line. Toxicology and Applied Pharmacology.   281(1):67-77. doi:10.1016/j.taap.2014.09.015  
2013
  • Boldenow, E., S. Jones, Richard W. Lieberman, Mark C. Chames, David M. Aronoff, Chuanwu Xi, and Rita Loch-Caruso. 2013. Antimicrobial peptide response to Group B Streptococcus in human extraplacental membranes in culture. Placenta.   34(6):480-485. doi:10.1016/j.placenta.2013.02.010  
  • Tetz, Lauren M., Adrienne A. Cheng, Cassandra Korte, Roger W. Giese, Poguang Wang, Craig Harris, John D. Meeker, and Rita Loch-Caruso. 2013. Mono-2-ethylhexyl phthalate induces oxidative stress responses in human placental cells in vitro. Toxicology and Applied Pharmacology.   268(1):47-54. doi:10.1016/j.taap.2013.01.020  
  • Tetz, Lauren M., Patricia W. Kamau, Adrienne A. Cheng, John D. Meeker, and Rita Loch-Caruso. 2013. Troubleshooting the dichlorofluorescein assay to avoid artifacts in measurement of toxicant-stimulated cellular production of reactive oxidant species. Journal of Pharmacological and Toxicological Methods. 67(2):56-60. doi:10.1016/j.vascn.2013.01.195  
2012
  • Cordero, Jose F., J.D. Meeker, Thomas C. Sheahan, Ingrid Padilla, Roger W. Giese, Michael Silevitch, Rita Loch-Caruso, David Kaeli, and Akram N. Alshawabkeh. 2012. Case Study - Puerto Rico Testsite for Exploring Contamination Threats. Proceedings of Geo-Congress. 3553-3562. doi:10.1061/9780784412121.364  
  • Ferguson, Kelly K., Rita Loch-Caruso, and John D. Meeker. 2012. Exploration of oxidative stress and inflammatory markers in relation to urinary phthalate metabolites: NHANES 1999-2006. Environmental Science & Technology.   46(1):477-485. doi:10.1021/es202340b  
  • Mao, Xuhui, Ali Ciblak, Kitae Baek, Mohammad Amiri, Rita Loch-Caruso, and Akram N. Alshawabkeh. 2012. Optimization of electrochemical dechlorination of trichloroethylene in reducing electrolytes. Water Research.   46(6):1847–1857. doi:10.1016/j.watres.2012.01.002  
  • Mao, Xuhui, Songhu Yuan, Noushin Fallahpour, Ali Ciblak, Joniqua Howard, Ingrid Padilla, Rita Loch-Caruso, and Akram N. Alshawabkeh. 2012. Electrochemically induced dual reactive barriers for transformation of TCE and mixture of contaminants in groundwater. Environmental Science & Technology.   46(21):12003-12011. doi:10.1021/es301711a  
  • Tetz, Lauren M., Rita Loch-Caruso, Roger W. Giese, and Poguang Wang. 2012. Mono-2-ethylhexyl phthalate induced oxidative stress in human placental cells. The Toxicologist - Supplement to Toxicol. Sci., Abstract #2383, 2012. .
  • Loch-Caruso, Rita, Kimani, P W, Park, H R. 2012. Brominated diphenyl ether-47 enhanced mRNA expression of pro-inflammatory cytokines and prostaglandin-endoperoxide synthase 2 in human placental cells. The Toxicologist - Supplement to Toxicol. Sci., Abstract #2386, 2012. .
  • Korte, Cassandra, Loch-Caruso, Rita. 2012. Oxidative insult activates parturition-associated pathways in a human placental cell line. The Toxicologist - Supplement to Toxicol. Sci., Abstract #2383, 2012. .
2011
2010
  • Silevitch, Michael, Roger W. Giese, David Kaeli, Thomas C. Sheahan, Mariah C. Nobrega, Akram N. Alshawabkeh, Jose F. Cordero, Ingrid Padilla, Rita Loch-Caruso, and John D. Meeker. 2010. Interdisciplinary Three-Level Approach to Study Impact of Contamination on Public Health in Puerto Rico. In: Proceedings of Sixth International Congress on Environmental Geotechnics. New Delhi,
  • Thiex, Natalie W., Mark C. Chames, and Rita Loch-Caruso. 2010. Tissue-specific induction of COX-2 and prostaglandins in lipopolysaccharide-stimulated extraplacental human gestational membranes in a 2-chamber transwell culture system. Reproductive Sciences.   17(12):1120-1129. doi:10.1177/1933719110378344  
2009
  • Meeker, John D., Howard Hu, David E. Cantonwine, Héctor Lamadrid-Figueroa, Antonia M. Calafat, Adrienne S. Ettinger, Mauricio Hernandez-Avila, Rita Loch-Caruso, and Martha Maria Tellez-Rojo. 2009. Urinary phthalate metabolites in relation to preterm birth in Mexico City. Environmental Health Perspectives. 117(10):1587-92.
2008
  • Tsuneta, T., Rita Loch-Caruso, John F. Quensen, Stephen A. Boyd, M. Hanna, and C. Grindatti. 2008. Stimulatory effects of a microbially dechlorinated polychlorinated biphenyl (PCB) mixture on rat uterine contraction in vitro. Environmental Research.   107(2):185-193. doi:10.1016/j.envres.2008.01.011  
2006
  • Brant, Kelly A. and Rita Loch-Caruso. 2006. PCB 50 stimulates release of arachidonic acid and prostaglandins from late gestation rat amnion fibroblast cells. Reproductive Toxicology.   22(4):591-8.
2005
  • Loch-Caruso, Rita, Brad L. Upham, Craig Harris, and James E. Trosko. 2005. Divergent roles for glutathione in lindane-induced acute and delayed-onset inhibition of rat myometrial gap junctions. Toxicological Sciences.   85(1):694-702.
2004
  • Brant, Kelly A. and Rita Loch-Caruso. 2004. Gestational increases and activation of rat uterine phospholipase A2 enzyme expression mediates PCB 50 - induced stimulation of uterine function. In: Proceedings of the 43rd Annual Meeting of the Society of Toxicology (SOT), March 21-25, 2004. Baltimore, MD.
  • Chung, Daesuk and Rita Loch-Caruso. 2004. Role of gap junctions in the modification on rat uterine contraction by 2,2'-dichlorobiphenyl. In: Proceedings of the 43rd Annual Meeting of the Society of Toxicology (SOT), March 21-25, 2004. Baltimore, MD.
  • Loch-Caruso, Rita, Maria M. Galvez, Kelly A. Brant, and Daesuk Chung. 2004. Cell and toxicant specific phosphorylation of conexin43: effects of lindane and TPA on rat myometrial and WB-F344 liver cell gap junctions. Cell Biology and Toxicology. 20(3):147-169. doi:10.1023/B:CBTO.0000029465.74815.62  
  • Loch-Caruso, Rita, T. Tsuneta, M. Hanna, C. Grindatti, and John F. Quensen. 2004. Stimulatory effects of a microbially dechlorinated polychlorinated biphenyl (PCB) mixture on rat uterine contraction in vitro. In: Proceedings of the 43rd Annual Meeting of the Society of Toxicology (SOT), March 21-25, 2004. Baltimore, MD.
2003
  • Brant, Kelly A. and Rita Loch-Caruso. 2003. iPLA2 contributes to the gestation day sensitivity to 2,2',4,6 tetrachlorobiphenyl-induced stimulation of contraction frequency in rat uterus. Biology of Reproduction.   68:382Suppl.1.
  • Chung, Daesuk and Rita Loch-Caruso. 2003. Role of oxidative stress in the modification on rat uterine contraction by 2,2 '-dichlorobiphenyl. Toxicological Sciences.   72(1):376.
  • Nasser, Fadia, Daesuk Chung, and Rita Loch-Caruso. 2003. Roles of endocannabinoids in rat uterine contractions. Biology of Reproduction.   68:390Suppl.1.
2002
2001
  • Bae, Jeehyeon, Mahmoud A. Mousa, John F. Quensen, Stephen A. Boyd, and Rita Loch-Caruso. 2001. Stimulation of contraction of pregnant rat uterus in vitro by non-dechlorinated and microbially dechlorinated mixtures of polychlorinated biphenyls. Environmental Health Perspectives. 109(3):275-282.
1999
  • Bae, Jeehyeon, M. Peters-Golden, and Rita Loch-Caruso. 1999. Stimulation of pregnant rat uterine contraction by the polychlorinated biphenyl (PCB) mixture Aroclor 1242 may be mediated by arachidonic acid release through activation of phospholipase A2 enzymes. Journal of Pharmacology and Experimental Therapeutics.   289:1112-1120.
  • Bae, Jeehyeon, Edward Stuenkel, and Rita Loch-Caruso. 1999. Stimulation of oscillatory uterine contraction by the PCB mixture Aroclor 1242 may involve increased [Ca2+]i through voltage-operated calcium channels. Toxicology and Applied Pharmacology.   155(3):261-272.
1997
  • Tsai, M-L, R.C. Webb, and Rita Loch-Caruso. 1997. The increase of oxytocin-induced oscillatory contractions by 4-hydroxy-2',4',6'-trichlorobiphenyl is estrogen receptor-mediated. Biology of Reproduction.   56(2):341-347.
1996
  • Bae, Jeehyeon and Rita Loch-Caruso. 1996. Stimulation of rat uterine oscillatory contraction by a polychlorinated biphenyl mixture, Aroclor 1242, and its sustained effect after removal of the compound. Biology of Reproduction.   54(supp.):182.
  • Loch-Caruso, Rita and M-L Tsai. 1996. Possible involvement of gap junctions in the development of spontaneous oscillatory contractions in uteri. Biology of Reproduction.   54(supp.):118.
  • Tsai, M-L, R.C. Webb, and Rita Loch-Caruso. 1996. Congener-specific effects of PCBs on contractions of pregnant rat uteri. Reproductive Toxicology.   10(1):21-28.
1995
  • Criswell, K.A. and Rita Loch-Caruso. 1995. Lindane-Induced Elimination of Gap Junctional Communication in Rat Uterine Myocytes Is Mediated by an Arachidonic Acid-Sensitive cAMP-Independent Mechanism. Toxicology and Applied Pharmacology.   135(1):127-138.
  • Criswell, K.A., Rita Loch-Caruso, and Edward Stuenkel. 1995. Lindane inhibition of gap junctional communication in myometrial myocytes is partially dependent on phosphoinositide-generated second messenger. Toxicology and Applied Pharmacology.   130:280-293.
  • Tsai, M-L, R.C. Webb, and Rita Loch-Caruso. 1995. Acute inhibition of uterine contraction by 4-hydroxy-2',4',6'-trichlorobiphenyl (4OHTCB) may result from disruption of gap junctional communication. The Toxicologist.   15:275.
  • Tsai, M-L, R.C. Webb, and Rita Loch-Caruso. 1995. Inhibition of spontaneous oscillatory uterine contractions by 17β-estradiol is associated with disruption of gap junctional communication. Biology of Reproduction.   52(supp.1):115.

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