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Study Information
Study Attribute Value
CEBS Accession Number: 002-01006-0034-0000-6
Chemical Name: Wyeth 14,643 (WY)
CASRN: 50892-23-4
NTP Study Type: Genetic Toxicology - Micronucleus
NTP Study ID: G91069
Strain and Species: Harlan Sprague Dawley Rat
Study Result: Male: Negative; Female: Negative

Blood

Start Date Sample Collection Time Sex Methodology Used Route Dosing Regimen
2012-02-24 24 hour Male Flow Cytometry Gavage Gavage x 28, 28 day
  Dose
(mg/kg)		 Animal
Number		 Polychromatic Erythrocytes
Trend P: 0.09568127399966087		 Normochromatic Erythrocytes
Trend P: 0.126316966577815
No. Examined Total MN Cells Percent PCE MN Cells
per 1000		 No. Examined Total MN Cells Percent NCE MN Cells
per 1000
Vehicle Control Deionized Water with 2% Tween 80 
 0         
 451 20000 16 1.1 0.8 1819113 204 98.9 0.1 
 0         
 452 20000 6 0.8 0.3 2413642 96 99.2 0.0 
 0         
 453 20000 7 1.0 0.4 1899474 192 99.0 0.1 
 0         
 454 20000 10 0.9 0.5 2263751 166 99.1 0.1 
 0         
 455 20000 12 1.0 0.6 1893505 126 99.0 0.1
Average ± SEM   0.974 ± 0.053 0.510 ± 0.090   0.000 ± 0.000 0.079 ± 0.013
 
Test Chemical Wyeth 14,643 (WY) 
6.25      
 461 20000 16 0.7 0.8 2755054 476 99.3 0.2 
6.25      
 462 20000 16 0.8 0.8 2447817 650 99.2 0.3 
6.25      
 463 20000 16 0.7 0.8 2822591 286 99.3 0.1 
6.25      
 464 20000 12 0.8 0.6 2457650 164 99.2 0.1 
6.25      
 465 20000 20 0.8 1.0 2634471 517 99.2 0.2
Average ± SEM   0.759 ± 0.022 0.800 ± 0.063   0.000 ± 0.000 0.161 ± 0.035
Pairwise P   0.055   0.131
 
Test Chemical Wyeth 14,643 (WY) 
12.5       
 471 20000 12 0.9 0.6 2125171 237 99.1 0.1 
12.5       
 472 20000 11 1.7 0.6 1144379 261 98.3 0.2 
12.5       
 473 20000 16 0.9 0.8 2174730 193 99.1 0.1 
12.5       
 474 20000 14 1.2 0.7 1706815 400 98.8 0.2 
12.5       
 475 20000 33 1.2 1.7 1708900 1357 98.8 0.8
Average ± SEM   1.175 ± 0.146 0.860 ± 0.202   0.000 ± 0.000 0.291 ± 0.129
Pairwise P   0.050   0.032
 
Test Chemical Wyeth 14,643 (WY) 
25         
 481 20000 21 1.0 1.1 1996432 411 99.0 0.2 
25         
 482 20000 12 1.3 0.6 1462435 98 98.7 0.1 
25         
 483 20000 16 1.0 0.8 1979703 242 99.0 0.1 
25         
 484 20000 14 1.0 0.7 1962819 129 99.0 0.1 
25         
 485 20000 16 1.1 0.8 1854541 255 98.9 0.1
Average ± SEM   1.083 ± 0.068 0.790 ± 0.075   0.000 ± 0.000 0.120 ± 0.026
Pairwise P   0.053   0.465
 

Blood

Start Date Sample Collection Time Sex Methodology Used Route Dosing Regimen
2012-02-25 24 hour Female Flow Cytometry Gavage Gavage x 28, 28 day
  Dose
(mg/kg)		 Animal
Number		 Polychromatic Erythrocytes
Trend P: 0.29183630126594623		 Normochromatic Erythrocytes
Trend P: 0.44646987566911356
No. Examined Total MN Cells Percent PCE MN Cells
per 1000		 No. Examined Total MN Cells Percent NCE MN Cells
per 1000
Vehicle Control Deionized Water with 2% Tween 80 
 0         
 491 20000 6 1.0 0.3 1929751 74 99.0 0.0 
 0         
 492 20000 10 1.4 0.5 1382209 51 98.6 0.0 
 0         
 493 20000 15 1.2 0.8 1700377 84 98.8 0.0 
 0         
 494 20000 11 0.9 0.6 2106381 57 99.1 0.0 
 0         
 495 20000 5 1.0 0.3 2054529 56 99.0 0.0
Average ± SEM   1.104 ± 0.089 0.470 ± 0.090   0.000 ± 0.000 0.036 ± 0.004
 
Test Chemical Wyeth 14,643 (WY) 
6.25      
 501 20000 15 1.2 0.8 1601823 76 98.8 0.0 
6.25      
 502 20000 23 1.0 1.2 1977820 137 99.0 0.1 
6.25      
 503 20000 9 0.9 0.5 2215874 102 99.1 0.0 
6.25      
 504 20000 17 0.7 0.9 2811364 206 99.3 0.1 
6.25      
 505 20000 9 0.9 0.5 2161672 111 99.1 0.1
Average ± SEM   0.950 ± 0.086 0.730 ± 0.132   0.000 ± 0.000 0.057 ± 0.006
Pairwise P   0.105   0.056
 
Test Chemical Wyeth 14,643 (WY) 
12.5       
 511 20000 10 1.3 0.5 1510174 40 98.7 0.0 
12.5       
 512 20000 12 1.2 0.6 1649084 48 98.8 0.0 
12.5       
 513 20000 17 1.5 0.9 1299638 71 98.5 0.1 
12.5       
 514 20608 10 1.1 0.5 1873318 148 98.9 0.1 
12.5       
 515 20000 9 1.3 0.5 1477205 45 98.7 0.0
Average ± SEM   1.289 ± 0.072 0.577 ± 0.073   0.000 ± 0.000 0.044 ± 0.010
Pairwise P   0.127   0.889
 
Test Chemical Wyeth 14,643 (WY) 
25         
 521 20722 12 1.7 0.6 1231182 43 98.3 0.0 
25         
 522 20000 9 1.3 0.5 1525073 85 98.7 0.1 
25         
 523 20000 15 1.1 0.8 1783976 51 98.9 0.0 
25         
 524 20000 15 1.3 0.8 1548455 57 98.7 0.0 
25         
 525 20000 11 1.7 0.6 1175862 50 98.3 0.0
Average ± SEM   1.401 ± 0.112 0.616 ± 0.059   0.000 ± 0.000 0.040 ± 0.005
Pairwise P   0.135   0.946