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Study Information
Study Attribute Value
CEBS Accession Number: 002-01006-0034-0000-6
Chemical Name: Wyeth 14,643 (WY)
CASRN: 50892-23-4
NTP Study Type: Genetic Toxicology - Micronucleus
NTP Study ID: G91069
Strain and Species: Harlan Sprague Dawley Rat
Study Result: Male: Negative; Female: Negative

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2012-02-24 24 hour Male PCE Flow Cytometry Gavage x 28, 28 day Gavage 0.096
  Dose (mg/kg) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control Deionized Water with 2% Tween 80 
 0         
 5 0.510 ± 0.090
Test Chemical Wyeth 14,643 (WY) 
6.25      
 5 0.800 ± 0.063 0.055 
12.5       
 5 0.860 ± 0.202 0.050 
25         
 5 0.790 ± 0.075 0.053

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2012-02-24 24 hour Male PCE Flow Cytometry Gavage x 28, 28 day Gavage 0.110
  Dose (mg/kg) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control Deionized Water with 2% Tween 80 
 0         
 5 0.974 ± 0.053
Test Chemical Wyeth 14,643 (WY) 
6.25      
 5 0.759 ± 0.022 1.000 
12.5       
 5 1.175 ± 0.146 0.236 
25         
 5 1.083 ± 0.068 0.249

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2012-02-24 24 hour Male NCE Flow Cytometry Gavage x 28, 28 day Gavage 0.126
  Dose (mg/kg) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Vehicle Control Deionized Water with 2% Tween 80 
 0         
 5 0.079 ± 0.013
Test Chemical Wyeth 14,643 (WY) 
6.25      
 5 0.161 ± 0.035 0.131 
12.5       
 5 0.291 ± 0.129 0.032 
25         
 5 0.120 ± 0.026 0.465

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2012-02-25 24 hour Female PCE Flow Cytometry Gavage x 28, 28 day Gavage 0.292
  Dose (mg/kg) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control Deionized Water with 2% Tween 80 
 0         
 5 0.470 ± 0.090
Test Chemical Wyeth 14,643 (WY) 
6.25      
 5 0.730 ± 0.132 0.105 
12.5       
 5 0.577 ± 0.073 0.127 
25         
 5 0.616 ± 0.059 0.135

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2012-02-25 24 hour Female PCE Flow Cytometry Gavage x 28, 28 day Gavage 0.013
  Dose (mg/kg) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control Deionized Water with 2% Tween 80 
 0         
 5 1.104 ± 0.089
Test Chemical Wyeth 14,643 (WY) 
6.25      
 5 0.950 ± 0.086 1.000 
12.5       
 5 1.289 ± 0.072 0.187 
25         
 5 1.401 ± 0.112 0.052

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2012-02-25 24 hour Female NCE Flow Cytometry Gavage x 28, 28 day Gavage 0.446
  Dose (mg/kg) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Vehicle Control Deionized Water with 2% Tween 80 
 0         
 5 0.036 ± 0.004
Test Chemical Wyeth 14,643 (WY) 
6.25      
 5 0.057 ± 0.006 0.056 
12.5       
 5 0.044 ± 0.010 0.889 
25         
 5 0.040 ± 0.005 0.946