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Study Information
Study Attribute Value
CEBS Accession Number: 002-02042-0014-0000-5
Chemical Name: Diethylstilbestrol
CASRN: 56-53-1
NTP Study Type: Genetic Toxicology - Micronucleus
NTP Study ID: A66561
Strain and Species: Tg.AC Mouse
Study Result: Male: Negative; Female: Negative

Blood

Start Date Sample Collection Time Sex Methodology Used Route Dosing Regimen
2000-04-25 24 hour Female Slide Scoring Gavage Gavage x 52, 26 week
  Dose
(ug/kg)		 Animal
Number		 Normochromatic Erythrocytes
Trend P: 0.156
No. Examined Total MN Cells Percent NCE MN Cells
per 1000
Vehicle Control Corn Oil 
 0         
 61 2000 0 96.7 0.0 
 0         
 62 2000 6 97.8 3.0 
 0         
 63 2000 3 97.3 1.5 
 0         
 64 2000 1 96.9 0.5 
 0         
 68 2000 4 96.1 2.0 
 0         
 69 2000 3 97.6 1.5 
 0         
 70 2000 1 98.0 0.5 
 0         
 74 2000 1 97.2 0.5
Average ± SEM   97.200 ± 0.220 1.190 ± 0.350
 
Test Chemical Diethylstilbestrol 
30         
 76 2000 4 96.4 2.0 
30         
 77 2000 2 96.6 1.0 
30         
 78 2000 1 97.3 0.5 
30         
 80 2000 2 97.8 1.0 
30         
 81 2000 1 97.3 0.5 
30         
 82 2000 1 97.7 0.5 
30         
 83 2000 5 98.5 2.5 
30         
 84 2000 3 97.1 1.5 
30         
 85 2000 4 97.4 2.0 
30         
 86 2000 3 98.4 1.5 
30         
 87 2000 1 97.5 0.5 
30         
 89 2000 4 97.3 2.0
Average ± SEM   97.440 ± 0.180 1.290 ± 0.210
Pairwise P   0.386
 
Test Chemical Diethylstilbestrol 
240         
 100 2000 1 98.0 0.5 
240         
 101 2000 3 97.5 1.5 
240         
 102 2000 1 98.4 0.5 
240         
 105 2000 1 98.0 0.5 
240         
 91 2000 1 97.8 0.5 
240         
 92 2000 1 98.7 0.5 
240         
 93 2000 0 96.6 0.0 
240         
 94 2000 1 97.0 0.5 
240         
 95 2000 4 97.6 2.0 
240         
 98 2000 2 97.0 1.0 
240         
 99 2000 2 96.9 1.0
Average ± SEM   97.590 ± 0.200 0.770 ± 0.170
Pairwise P   0.903
 
Test Chemical Diethylstilbestrol 
480         
 108 2000 6 98.3 3.0 
480         
 110 2000 2 97.4 1.0 
480         
 113 2000 3 97.4 1.5 
480         
 114 2000 4 98.4 2.0 
480         
 115 2000 3 98.0 1.5 
480         
 116 2000 5 98.3 2.5 
480         
 118 2000 2 97.2 1.0 
480         
 119 2000 3 97.9 1.5
Average ± SEM   97.860 ± 0.170 1.750 ± 0.250
Pairwise P   0.095
 

Blood

Start Date Sample Collection Time Sex Methodology Used Route Dosing Regimen
2000-04-25 24 hour Male Slide Scoring Gavage Gavage x 52, 26 week
  Dose
(ug/kg)		 Animal
Number		 Normochromatic Erythrocytes
Trend P: 0.237
No. Examined Total MN Cells Percent NCE MN Cells
per 1000
Vehicle Control Corn Oil 
 0         
 1 2000 1 96.5 0.5 
 0         
 10 2000 3 96.5 1.5 
 0         
 12 2000 0 96.9 0.0 
 0         
 13 2000 1 92.2 0.5 
 0         
 15 2000 3 97.1 1.5 
 0         
 2 2000 3 97.6 1.5 
 0         
 3 2000 2 97.1 1.0 
 0         
 4 2000 0 92.3 0.0 
 0         
 6 2000 3 97.2 1.5 
 0         
 7 2000 1 97.4 0.5 
 0         
 8 2000 3 97.9 1.5 
 0         
 9 2000 4 94.6 2.0
Average ± SEM   96.110 ± 0.570 1.000 ± 0.190
 
Test Chemical Diethylstilbestrol 
30         
 17 2000 0 97.5 0.0 
30         
 18 2000 3 96.2 1.5 
30         
 19 2000 3 97.6 1.5 
30         
 22 2000 1 96.0 0.5 
30         
 23 2000 4 97.2 2.0 
30         
 24 2000 5 96.3 2.5 
30         
 25 2000 4 98.1 2.0 
30         
 26 2000 0 96.1 0.0 
30         
 27 2000 4 96.6 2.0 
30         
 28 2000 3 96.3 1.5 
30         
 30 2000 2 96.7 1.0
Average ± SEM   96.780 ± 0.210 1.320 ± 0.250
Pairwise P   0.158
 
Test Chemical Diethylstilbestrol 
240         
 31 2000 4 97.3 2.0 
240         
 32 2000 1 96.3 0.5 
240         
 33 2000 1 96.5 0.5 
240         
 34 2000 1 96.1 0.5 
240         
 35 2000 1 96.4 0.5 
240         
 36 2000 2 97.0 1.0 
240         
 37 2000 0 91.2 0.0 
240         
 38 2000 4 95.1 2.0 
240         
 39 2000 1 96.6 0.5 
240         
 40 2000 1 98.6 0.5 
240         
 41 2000 1 97.6 0.5 
240         
 42 2000 1 97.2 0.5 
240         
 45 2000 1 98.3 0.5
Average ± SEM   96.480 ± 0.510 0.730 ± 0.170
Pairwise P   0.848
 
Test Chemical Diethylstilbestrol 
480         
 48 2000 3 95.8 1.5 
480         
 49 2000 1 96.6 0.5 
480         
 50 2000 1 94.6 0.5 
480         
 51 2000 4 95.6 2.0 
480         
 53 2000 6 93.7 3.0 
480         
 54 2000 2 97.6 1.0 
480         
 55 2000 4 96.3 2.0 
480         
 56 2000 3 97.1 1.5 
480         
 57 2000 1 97.6 0.5 
480         
 58 2000 2 97.7 1.0 
480         
 59 2000 1 97.6 0.5 
480         
 60 2000 6 97.3 3.0
Average ± SEM   96.460 ± 0.380 1.420 ± 0.270
Pairwise P   0.094