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Study Information
Study Attribute Value
CEBS Accession Number: 002-02128-0002-0000-7
Chemical Name: Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE)
CASRN: 54464-57-2
NTP Study Type: Genetic Toxicology - Micronucleus
NTP Study ID: F35719
Strain and Species: B6C3F1 Mouse
Study Result: Male: Equivocal; Female: Positive

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-15 24 hour Male PCE Flow Cytometry Dermal x 91, 13 week Dermal 0.865
  Dose (%) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control 95% Ethanol 
 0         
 5 2.420 ± 0.160
Test Chemical Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) 
6.25      
 5 2.550 ± 0.240 0.397 
12.5       
 5 2.780 ± 0.300 0.471 
25         
 5 2.430 ± 0.200 0.501 
50         
 5 2.240 ± 0.140 0.518

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-15 24 hour Male PCE Flow Cytometry Dermal x 91, 13 week Dermal 0.851
  Dose (%) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control 95% Ethanol 
 0         
 5 1.455 ± 0.079
Test Chemical Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) 
6.25      
 5 1.524 ± 0.120 0.620 
12.5       
 5 1.583 ± 0.080 0.651 
25         
 5 1.518 ± 0.042 0.695 
50         
 5 1.466 ± 0.054 0.717

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-15 24 hour Male NCE Flow Cytometry Dermal x 91, 13 week Dermal 0.442
  Dose (%) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Vehicle Control 95% Ethanol 
 0         
 5 1.470 ± 0.020
Test Chemical Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) 
6.25      
 5 1.480 ± 0.040 0.703 
12.5       
 5 1.430 ± 0.040 0.787 
25         
 5 1.390 ± 0.050 0.820 
50         
 5 1.490 ± 0.020 0.477

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-15 24 hour Male PCE Flow Cytometry Dermal x 91, 13 week Dermal
  Dose (%) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Untreated Control 
 0         
 5 2.660 ± 0.140
Test Chemical Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) 
100         
 5 2.290 ± 0.150 0.805

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-15 24 hour Male PCE Flow Cytometry Dermal x 91, 13 week Dermal
  Dose (%) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Untreated Control 
 0         
 5 1.599 ± 0.059
Test Chemical Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) 
100         
 5 2.000 ± 0.196 0.066

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-15 24 hour Male NCE Flow Cytometry Dermal x 91, 13 week Dermal
  Dose (%) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Untreated Control 
 0         
 5 1.450 ± 0.020
Test Chemical Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) 
100         
 5 1.590 ± 0.030 0.001

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-15 24 hour Male PCE Flow Cytometry Dermal x 91, 13 week Dermal
  Dose (%) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control 95% Ethanol 
 0         
 5 2.420 ± 0.160 0.707
Untreated Control 
 0         
 5 2.660 ± 0.140

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-15 24 hour Male PCE Flow Cytometry Dermal x 91, 13 week Dermal
  Dose (%) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control 95% Ethanol 
 0         
 5 1.455 ± 0.079 0.190
Untreated Control 
 0         
 5 1.599 ± 0.059

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-15 24 hour Male NCE Flow Cytometry Dermal x 91, 13 week Dermal
  Dose (%) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Vehicle Control 95% Ethanol 
 0         
 5 1.470 ± 0.020 0.235
Untreated Control 
 0         
 5 1.450 ± 0.020

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-16 24 hour Female PCE Flow Cytometry Dermal x 91, 13 week Dermal 0.856
  Dose (%) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control 95% Ethanol 
 0         
 5 2.130 ± 0.120
Test Chemical Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) 
6.25      
 5 1.760 ± 0.100 0.877 
12.5       
 5 2.150 ± 0.050 0.887 
25         
 5 1.950 ± 0.140 0.912 
50         
 5 1.850 ± 0.120 0.924

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-16 24 hour Female PCE Flow Cytometry Dermal x 91, 13 week Dermal 0.050
  Dose (%) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control 95% Ethanol 
 0         
 5 1.522 ± 0.116
Test Chemical Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) 
6.25      
 5 1.510 ± 0.092 1.000 
12.5       
 5 2.060 ± 0.134 0.053 
25         
 5 1.842 ± 0.207 0.056 
50         
 5 1.961 ± 0.140 0.045

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-16 24 hour Female NCE Flow Cytometry Dermal x 91, 13 week Dermal <0.001
  Dose (%) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Vehicle Control 95% Ethanol 
 0         
 5 1.010 ± 0.020
Test Chemical Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) 
6.25      
 5 1.010 ± 0.020 0.472 
12.5       
 5 1.070 ± 0.040 0.064 
25         
 5 1.080 ± 0.020 0.039 
50         
 5 1.150 ± 0.010 0.001

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-16 24 hour Female PCE Flow Cytometry Dermal x 91, 13 week Dermal
  Dose (%) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Untreated Control 
 0         
 5 1.980 ± 0.140
Test Chemical Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) 
100         
 5 2.880 ± 0.230 0.005

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-16 24 hour Female PCE Flow Cytometry Dermal x 91, 13 week Dermal
  Dose (%) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Untreated Control 
 0         
 5 1.075 ± 0.149
Test Chemical Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) 
100         
 5 1.893 ± 0.246 0.031

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-16 24 hour Female NCE Flow Cytometry Dermal x 91, 13 week Dermal
  Dose (%) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Untreated Control 
 0         
 5 1.030 ± 0.040
Test Chemical Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) 
100         
 5 1.270 ± 0.010 <0.001

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-16 24 hour Female PCE Flow Cytometry Dermal x 91, 13 week Dermal
  Dose (%) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control 95% Ethanol 
 0         
 5 2.130 ± 0.120 0.230
Untreated Control 
 0         
 5 1.980 ± 0.140

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-16 24 hour Female PCE Flow Cytometry Dermal x 91, 13 week Dermal
  Dose (%) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control 95% Ethanol 
 0         
 5 1.522 ± 0.116 0.048
Untreated Control 
 0         
 5 1.075 ± 0.149

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-16 24 hour Female NCE Flow Cytometry Dermal x 91, 13 week Dermal
  Dose (%) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Vehicle Control 95% Ethanol 
 0         
 5 1.010 ± 0.020 0.581
Untreated Control 
 0         
 5 1.030 ± 0.040