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Study Information
Study Attribute Value
CEBS Accession Number: 002-02706-0009-0000-6
Chemical Name: Polybrominated biphenyl mixture (Firemaster FF-1)
CASRN: 67774-32-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 103512_CA
Study Result: Negative

View Detailed Data
Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 02/01/89 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.5334
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 11.75 ± 2.15 0.0000
Test Chemical Polybrominated biphenyl mixture (Firemaster FF-1) 
1250         
 8 5.50 ± 2.20 0.0046
  
2500         
 8 7.00 ± 1.56 0.0003
  
5000         
 8 2.50 ± 0.73 0.3168
Vehicle Control No Stressor 
 0         
 8 2.00 ± 0.53 0.0000


View Detailed Data
Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 12/02/91 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.6538
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 7 7.71 ± 2.16 0.0000
Test Chemical Polybrominated biphenyl mixture (Firemaster FF-1) 
1250         
 8 0.50 ± 0.33 0.7938
  
2500         
 8 0.00 ± 0.00 0.9775
  
5000         
 8 0.75 ± 0.37 0.6479
Vehicle Control No Stressor 
 0         
 8 1.00 ± 0.53 0.0000


View Detailed Data
Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 12/08/92 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.1220
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 36.00 ± 3.25 0.0000
Test Chemical Polybrominated biphenyl mixture (Firemaster FF-1) 
1250         
 7 2.00 ± 0.76 0.0682
  
2500         
 8 1.75 ± 0.80 0.1015
  
5000         
 8 2.00 ± 0.65 0.0645
Vehicle Control No Stressor 
 0         
 8 0.75 ± 0.37 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed