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Your Environment. Your Health.

ROLE OF EPIGENETICALLY ACTIVE ENVIRONMENTAL COMPOUNDS IN NEURODEVELOPMENTAL DISORDERS

Export to Word (http://www.niehs.nih.gov//portfolio/index.cfm/portfolio/grantdetail/grant_number/R21ES030804/format/word)
Principal Investigator: Terskikh, Alexey V
Institute Receiving Award Sanford Burnham Prebys Medical Discovery Institute
Location La Jolla, CA
Grant Number R21ES030804
Funding Organization National Institute of Environmental Health Sciences
Award Funding Period 25 Sep 2020 to 31 Aug 2022
DESCRIPTION (provided by applicant): PROJECT SUMMARY Neurodevelopmental disorders (NDDs), are increasingly recognized as originating from dysregulation of early brain development, which represents a window of vulnerability to environmental compounds. Environmental compounds may alter neurodevelopment via epigenetic mechanisms, which may not induce massive cell death, but change the brain function through their epigenetic effect on stem cell fate and lineage development. However, tools to systematically examine the epigenetic impact of environment on neurodevelopment are lacking. Here we employ Microscopic Imaging of Epigenetic Landscape (MIEL) to screen ToxCast Phase III chemical library (4700 compounds) and to characterize hits that alter epigenetic landscape of human neural precursors without inducing cytotoxicity. Recognizing environmental insults and understanding their mechanism of action will enable the development of regulations and guidelines aimed at avoiding such insults and the development of antidotes and protective agents when exposure is unavoidable.
Science Code(s)/Area of Science(s) Primary: 61 - Neurodevelopmental
Secondary: 03 - Carcinogenesis/Cell Transformation
Publications No publications associated with this grant
Program Officer Jonathan Hollander
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