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Your Environment. Your Health.

Who We Fund: Publication Detail

Project Title: MECHANISTIC EVALUATION OF CHEMICALS THAT INDUCE ORAL ACUTE TOXICITY BY NOVEL READ-ACROSS APPROACHES USING PUBLIC BIG DATA
PI: Zhu, Hao
Institution: Rutgers The State Univ Of Nj Camden
Grant Number: R15ES023148

These search results have not been confirmed by NIEHS and are therefore, not official. They are to be used only for general information and to inform the public and grantees on the breadth of research funded by NIEHS.

Viewing 43 publications
Export to Excel (http://www.niehs.nih.gov//portfolio/index.cfm/portfolio/grantpubdetail/grant_number/R15ES023148/format/excel)
Publication Title Authors Grant Number(s) Journal (Pub date) PubMed Link Pub Year
Advancing computer-aided drug discovery (CADD) by big data and data-driven machine learning modeling ...   Zhao, Linlin; Ciallella, Heather L; Aleksunes, Lauren M; Zhu, Hao P30ES005022, R01ES031080, R15ES023148, R15ES023148 Drug Discov Today (2020 09) 32663517 Exiting the NIEHS site 2020 
Analysis of model PM2.5-induced inflammation and cytotoxicity by the combination of a virtual carbon ...   Liu, Guohong; Yan, Xiliang; Sedykh, Alexander; Pan, Xiujiao; Zhao, Xiaoli; Yan, Bing; Zhu, Ha ... R15ES023148, R15ES023148 Ecotoxicol Environ Saf (2020 Mar 15) 31972454 Exiting the NIEHS site 2020 
Big Data and Artificial Intelligence Modeling for Drug Discovery.   Zhu, Hao R15ES023148, R15ES023148 Annu Rev Pharmacol Toxicol (2020 01 06) 31518513 Exiting the NIEHS site 2020 
Construction of a web-based nanomaterial database by big data curation and modeling friendly nanostr ...   Yan, Xiliang; Sedykh, Alexander; Wang, Wenyi; Yan, Bing; Zhu, Hao P30ES005022, R01ES031080, R15ES023148, R15ES023148 Nat Commun (2020 05 20) 32433469 Exiting the NIEHS site 2020 
Mechanism-Driven Read-Across of Chemical Hepatotoxicants Based on Chemical Structures and Biological ...   Zhao, Linlin; Russo, Daniel P; Wang, Wenyi; Aleksunes, Lauren M; Zhu, Hao P30ES005022, R01ES031080, R15ES023148, R15ES023148 Toxicol Sci (2020 04 01) 32073637 Exiting the NIEHS site 2020 
Predictive modeling of estrogen receptor agonism, antagonism, and binding activities using machine- ...   Ciallella, Heather L; Russo, Daniel P; Aleksunes, Lauren M; Grimm, Fabian A; Zhu, Hao P30ES005022, R01ES031080, R15ES023148, R15ES023148 Lab Invest (2020 Aug 10) 32778734 Exiting the NIEHS site 2020 
Advancing Computational Toxicology in the Big Data Era by Artificial Intelligence: Data-Driven and M ...   Ciallella, Heather L; Zhu, Hao R15ES023148, R15ES023148 Chem Res Toxicol (2019 04 15) 30907586 Exiting the NIEHS site 2019 
Nonanimal Models for Acute Toxicity Evaluations: Applying Data-Driven Profiling and Read-Across.   Russo, Daniel P; Strickland, Judy; Karmaus, Agnes L; Wang, Wenyi; Shende, Sunil; Hartung, Thom ... R15ES023148, R15ES023148 Environ Health Perspect (2019 04) 30933541 Exiting the NIEHS site 2019 
Using a hybrid read-across method to evaluate chemical toxicity based on chemical structure and biol ...   Guo, Yajie; Zhao, Linlin; Zhang, Xiaoyi; Zhu, Hao R15ES023148, R15ES023148 Ecotoxicol Environ Saf (2019 Aug 30) 31004930 Exiting the NIEHS site 2019 
Comparing Multiple Machine Learning Algorithms and Metrics for Estrogen Receptor Binding Prediction.   Russo, Daniel P; Zorn, Kimberley M; Clark, Alex M; Zhu, Hao; Ekins, Sean R15ES023148, R15ES023148 Mol Pharm (2018 10 01) 30114914 Exiting the NIEHS site 2018 
Alternative approaches for identifying acute systemic toxicity: Moving from research to regulatory t ...   Hamm, Jon; Sullivan, Kristie; Clippinger, Amy J; Strickland, Judy; Bell, Shannon; Bhhatarai, B ... P30ES005022, R15ES023148, R15ES023148 Toxicol In Vitro (2017 Jun) 28069485 Exiting the NIEHS site 2017 
CIIPro: a new read-across portal to fill data gaps using public large-scale chemical and biological ...   Russo, Daniel P; Kim, Marlene T; Wang, Wenyi; Pinolini, Daniel; Shende, Sunil; Strickland, Jud ... P30ES005022, R15ES023148, R15ES023148 Bioinformatics (2017 02 01) 28172359 Exiting the NIEHS site 2017 
Elucidation of the Molecular Determinants for Optimal Perfluorooctanesulfonate Adsorption Using a Co ...   Liu, Yin; Su, Gaoxing; Wang, Fei; Jia, Jianbo; Li, Shuhuan; Zhao, Linlin; Shi, Yali; Cai, Ya ... R15ES023148, R15ES023148 Environ Sci Technol (2017 Jun 20) 28537376 Exiting the NIEHS site 2017 
Experimental Errors in QSAR Modeling Sets: What We Can Do and What We Cannot Do.   Zhao, Linlin; Wang, Wenyi; Sedykh, Alexander; Zhu, Hao P30ES005022, R15ES023148, R15ES023148 ACS Omega (2017 Jun 30) 28691113 Exiting the NIEHS site 2017 
Predicting Nano-Bio Interactions by Integrating Nanoparticle Libraries and Quantitative Nanostructur ...   Wang, Wenyi; Sedykh, Alexander; Sun, Hainan; Zhao, Linlin; Russo, Daniel P; Zhou, Hongyu; Yan, ... P30ES005022, R15ES023148, R15ES023148 ACS Nano (2017 12 26) 29149552 Exiting the NIEHS site 2017 
Toward a systematic exploration of nano-bio interactions.   Bai, Xue; Liu, Fang; Liu, Yin; Li, Cong; Wang, Shenqing; Zhou, Hongyu; Wang, Wenyi; Zhu, Hao ... P30ES005022, R15ES023148, R15ES023148 Toxicol Appl Pharmacol (2017 05 15) 28344110 Exiting the NIEHS site 2017 
Accessing the High-Throughput Screening Data Landscape.   Russo, Daniel P; Zhu, Hao R15ES023148, R15ES023148 Methods Mol Biol (2016) 27518633 Exiting the NIEHS site 2016 
Analysis of Draize eye irritation testing and its prediction by mining publicly available 2008-2014 ...   Luechtefeld, Thomas; Maertens, Alexandra; Russo, Daniel P; Rovida, Costanza; Zhu, Hao; Hartung, ... R15ES023148, R15ES023148, T32ES007141 ALTEX (2016) 26863293 Exiting the NIEHS site 2016 
Analysis of public oral toxicity data from REACH registrations 2008-2014.   Luechtefeld, Thomas; Maertens, Alexandra; Russo, Daniel P; Rovida, Costanza; Zhu, Hao; Hartung, ... R15ES023148, R15ES023148, T32ES007141 ALTEX (2016) 26863198 Exiting the NIEHS site 2016 
Analysis of publically available skin sensitization data from REACH registrations 2008-2014.   Luechtefeld, Thomas; Maertens, Alexandra; Russo, Daniel P; Rovida, Costanza; Zhu, Hao; Hartung, ... R15ES023148, R15ES023148, T32ES007141 ALTEX (2016) 26863411 Exiting the NIEHS site 2016 
CIIPro: a new read-across portal to fill data gaps using public large-scale chemical and biological ...   Russo, Daniel P; Kim, Marlene T; Wang, Wenyi; Pinolini, Daniel; Shende, Sunil; Strickland, Jud ... P30ES005022, R15ES023148, R15ES023148 Bioinformatics (2016 Oct 14) 27742693 Exiting the NIEHS site 2016 
Curating and Preparing High-Throughput Screening Data for Quantitative Structure-Activity Relationsh ...   Kim, Marlene T; Wang, Wenyi; Sedykh, Alexander; Zhu, Hao R15ES023148, R15ES023148 Methods Mol Biol (2016) 27518634 Exiting the NIEHS site 2016 
Discovery of Novel Tricyclic Thiazepine Derivatives as Anti-Drug-Resistant Cancer Agents by Combinin ...   Xiang, Jinbao; Zhang, Zhuoqi; Mu, Yan; Xu, Xianxiu; Guo, Sigen; Liu, Yongjin; Russo, Daniel P ... P30ES005022, R15ES023148, R15ES023148 ACS Comb Sci (2016 05 09) 27082930 Exiting the NIEHS site 2016 
From fighting depression to conquering tumors: a novel tricyclic thiazepine compound as a tubulin po ...   Mu, Y; Liu, Y; Xiang, J; Zhang, Q; Zhai, S; Russo, D P; Zhu, H; Bai, X; Yan, B R15ES023148, R15ES023148 Cell Death Dis (2016 Mar 17) 26986511 Exiting the NIEHS site 2016 
Global analysis of publicly available safety data for 9,801 substances registered under REACH from 2 ...   Luechtefeld, Thomas; Maertens, Alexandra; Russo, Daniel P; Rovida, Costanza; Zhu, Hao; Hartung, ... R15ES023148, R15ES023148, T32ES007141 ALTEX (2016) 26863090 Exiting the NIEHS site 2016 
Mechanism Profiling of Hepatotoxicity Caused by Oxidative Stress Using Antioxidant Response Element ...   Kim, Marlene Thai; Huang, Ruili; Sedykh, Alexander; Wang, Wenyi; Xia, Menghang; Zhu, Hao P30ES005022, R15ES023148, R15ES023148 Environ Health Perspect (2016 05) 26383846 Exiting the NIEHS site 2016 
Predictive Modeling of Estrogen Receptor Binding Agents Using Advanced Cheminformatics Tools and Mas ...   Ribay, Kathryn; Kim, Marlene T; Wang, Wenyi; Pinolini, Daniel; Zhu, Hao P30ES005022, R15ES023148, R15ES023148 Front Environ Sci (2016 Mar) 27642585 Exiting the NIEHS site 2016 
Supporting read-across using biological data.   Zhu, Hao; Bouhifd, Mounir; Donley, Elizabeth; Egnash, Laura; Kleinstreuer, Nicole; Kroese, E D ... P30ES005022, R15ES023148, R15ES023148, T32ES007141 ALTEX (2016) 26863516 Exiting the NIEHS site 2016 
Toward Good Read-Across Practice (GRAP) guidance.   Ball, Nicholas; Cronin, Mark T D; Shen, Jie; Blackburn, Karen; Booth, Ewan D; Bouhifd, Mounir; ... P30ES005022, R15ES023148, R15ES023148, T32ES007141 ALTEX (2016) 26863606 Exiting the NIEHS site 2016 
Developing Enhanced Blood-Brain Barrier Permeability Models: Integrating External Bio-Assay Data in ...   Wang, Wenyi; Kim, Marlene T; Sedykh, Alexander; Zhu, Hao R15ES023148, R15ES023148 Pharm Res (2015 Sep) 25862462 Exiting the NIEHS site 2015 
Experimental modulation and computational model of nano-hydrophobicity.   Li, Shuhuan; Zhai, Shumei; Liu, Yin; Zhou, Hongyu; Wu, Jinmei; Jiao, Qing; Zhang, Bin; Zhu, ... R15ES023148, R15ES023148 Biomaterials (2015 Jun) 25818437 Exiting the NIEHS site 2015 
Improving both aqueous solubility and anti-cancer activity by assessing progressive lead optimizatio ...   Liu, Yin; Li, Fei; Wu, Ling; Wang, Wenyi; Zhu, Hao; Zhang, Qiu; Zhou, Hongyu; Yan, Bing R15ES023148, R15ES023148 Bioorg Med Chem Lett (2015 May 01) 25827524 Exiting the NIEHS site 2015 
Big data in chemical toxicity research: the use of high-throughput screening assays to identify pote ...   Zhu, Hao; Zhang, Jun; Kim, Marlene T; Boison, Abena; Sedykh, Alexander; Moran, Kimberlee R15ES023148, R15ES023148 Chem Res Toxicol (2014 Oct 20) 25195622 Exiting the NIEHS site 2014 
Critical evaluation of human oral bioavailability for pharmaceutical drugs by using various cheminfo ...   Kim, Marlene T; Sedykh, Alexander; Chakravarti, Suman K; Saiakhov, Roustem D; Zhu, Hao R15ES023148, R15ES023148 Pharm Res (2014 Apr) 24306326 Exiting the NIEHS site 2014 
Design, synthesis and experimental validation of novel potential chemopreventive agents using random ...   Sprague, Brienne; Shi, Qian; Kim, Marlene T; Zhang, Liying; Sedykh, Alexander; Ichiishi, Eiich ... R15ES023148, R15ES023148 J Comput Aided Mol Des (2014 Jun) 24840854 Exiting the NIEHS site 2014 
Profiling animal toxicants by automatically mining public bioassay data: a big data approach for com ...   Zhang, Jun; Hsieh, Jui-Hua; Zhu, Hao R15ES023148, R15ES023148 PLoS One (2014) 24950175 Exiting the NIEHS site 2014 
Tuning cell autophagy by diversifying carbon nanotube surface chemistry.   Wu, Ling; Zhang, Yi; Zhang, Chengke; Cui, Xuehui; Zhai, Shumei; Liu, Yin; Li, Changlong; Zhu, ... R15ES023148, R15ES023148 ACS Nano (2014 Mar 25) 24552177 Exiting the NIEHS site 2014 
Discovery of novel antimalarial compounds enabled by QSAR-based virtual screening.   Zhang, Liying; Fourches, Denis; Sedykh, Alexander; Zhu, Hao; Golbraikh, Alexander; Ekins, Sean ... R15ES023148, R15ES023148 J Chem Inf Model (2013 Feb 25) 23252936 Exiting the NIEHS site 2013 
From QSAR to QSIIR: searching for enhanced computational toxicology models.   Zhu, Hao R15ES023148, R15ES023148 Methods Mol Biol (2013) 23086837 Exiting the NIEHS site 2013 
Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux an ...   Sedykh, Alexander; Fourches, Denis; Duan, Jianmin; Hucke, Oliver; Garneau, Michel; Zhu, Hao; B ... R15ES023148, R15ES023148 Pharm Res (2013 Apr) 23269503 Exiting the NIEHS site 2013 
Identification of putative estrogen receptor-mediated endocrine disrupting chemicals using QSAR- and ...   Zhang, Liying; Sedykh, Alexander; Tripathi, Ashutosh; Zhu, Hao; Afantitis, Antreas; Mouchlis, ... R15ES023148, R15ES023148 Toxicol Appl Pharmacol (2013 Oct 01) 23707773 Exiting the NIEHS site 2013 
The use of pseudo-equilibrium constant affords improved QSAR models of human plasma protein binding.   Zhu, Xiang-Wei; Sedykh, Alexander; Zhu, Hao; Liu, Shu-Shen; Tropsha, Alexander R15ES023148, R15ES023148 Pharm Res (2013 Jul) 23568522 Exiting the NIEHS site 2013 
Predicting chemical ocular toxicity using a combinatorial QSAR approach.   Solimeo, Renee; Zhang, Jun; Kim, Marlene; Sedykh, Alexander; Zhu, Hao R15ES023148, R15ES023148 Chem Res Toxicol (2012 Dec 17) 23148656 Exiting the NIEHS site 2012 
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