Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Haemoglobin adducts of aromatic amines in people exposed to cigarette smoke.

Authors: Bryant, M S; Vineis, P; Skipper, P L; Tannenbaum, S R

Published In IARC Sci Publ, (1988)

Abstract: In a population-based study in Turin, Italy, smokers of blond tobacco showed 4-aminobiphenyl (4-ABP) adduct levels some three times higher than nonsmoking subjects, and smokers of black tobacco showed levels about five times greater than nonsmokers. A dose-response relationship between the number of cigarettes smoked per day and 4-ABP adduct level was observed, but did not account for the higher adduct levels observed in smokers of black tobacco. Smoking-related increases in haemoglobin adducts were also observed for o-toluidine, p-toluidine, 2,4-dimethylaniline and 2-ethylaniline. Smoking subjects showed 3-aminobiphenyl adduct levels about 12 times greater than those of nonsmokers, who rarely showed a detectable level. This may indicate that there are fewer sources of 3-aminobiphenyl exposure not related to tobacco smoke. Smokers of black tobacco showed higher adduct levels than smokers of blond tobacco for 4-ABP, p-toluidine and 2,4-dimethylaniline.

PubMed ID: 3198197 Exiting the NIEHS site

MeSH Terms: 2-Naphthylamine/blood; Adult; Aminobiphenyl Compounds/blood*; Environmental Monitoring; Hemoglobins/metabolism*; Humans; Male; Smoking/blood*; Urinary Bladder Neoplasms/etiology

Back
to Top