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Publication Detail

Title: Responses of dopaminergic and serotonergic systems to triethyllead intoxication.

Authors: DeHaven-Hudkins, D L; Schulz, D W; Walsh, T J; Mailman, R B

Published In Neurotoxicol Teratol, (1988 Jul-Aug)

Abstract: Rats treated with triethyllead (TEL) exhibit a behavioral supersensitivity to challenge with dopamine agonists at 7 days following administration of TEL. In the present series of experiments, some neurochemical mechanisms which may affect this behavioral supersensitivity were detected. Administration of a single dose of TEL chloride (7.88 mg/kg, SC) to male Fischer-344 rats decreased the concentrations of dopamine in hippocampus, and of serotonin in olfactory tubercle, at Day 7 posttreatment. The ratio of 5-hydroxyindoleacetic acid/5-hydroxytryptamine (one estimate of serotonin turnover) was increased in nucleus accumbens (p less than 0.05), with a similar trend in olfactory tubercle and striatum (p less than 0.10). No changes were detected in binding of [3H]spiperone to D2 dopamine receptors in striatum or olfactory tubercle. However, although basal adenylate cyclase activity was unaltered in TEL-treated rats, the Vmax for dopamine-stimulated adenylate cyclase activity was significantly elevated in olfactory tubercle. Conversely, TEL at micromolar concentrations markedly attenuated both basal and dopamine-stimulated adenylate cyclase activity in vitro in striatal homogenates. These data suggest the hypothesis that administration of TEL to rats results in an up-regulation of D1 dopamine receptors in olfactory tubercle, and that the behavioral supersensitivity of TEL-treated animals to dopamine agonists may, in part, be a result of this receptor supersensitivity.

PubMed ID: 2465482 Exiting the NIEHS site

MeSH Terms: Animals; Brain/drug effects; Brain/metabolism*; Cyclic AMP/metabolism; Dopamine/metabolism*; Hydroxyindoleacetic Acid/metabolism; Male; Neurotoxins/pharmacology*; Organometallic Compounds/toxicity*; Rats; Receptors, Serotonin/drug effects; Receptors, Serotonin/metabolism; Serotonin/metabolism*; Spiperone/metabolism; Time Factors

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