Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document
Use this QR code to view the newest version of this document

Your Environment. Your Health.

Publication Detail

Title: Ubiquitin lysine 63 chain forming ligases regulate apical dominance in Arabidopsis.

Authors: Yin, Xiao-Jun; Volk, Sara; Ljung, Karin; Mehlmer, Norbert; Dolezal, Karel; Ditengou, Franck; Hanano, Shigeru; Davis, Seth J; Schmelzer, Elmon; Sandberg, Göran; Teige, Markus; Palme, Klaus; Pickart, Cecile; Bachmair, Andreas

Published In Plant Cell, (2007 Jun)

Abstract: Lys-63-linked multiubiquitin chains play important roles in signal transduction in yeast and in mammals, but the functions for this type of chain in plants remain to be defined. The RING domain protein RGLG2 (for RING domain Ligase2) from Arabidopsis thaliana can be N-terminally myristoylated and localizes to the plasma membrane. It can form Lys-63-linked multiubiquitin chains in an in vitro reaction. RGLG2 has overlapping functions with its closest sequelog, RGLG1, and single mutants in either gene are inconspicuous. rglg1 rglg2 double mutant plants exhibit loss of apical dominance and altered phyllotaxy, two traits critically influenced by the plant hormone auxin. Auxin and cytokinin levels are changed, and the plants show a decreased response to exogenously added auxin. Changes in the abundance of PIN family auxin transport proteins and synthetic lethality with a mutation in the auxin transport regulator BIG suggest that the directional flow of auxin is modulated by RGLG activity. Modification of proteins by Lys-63-linked multiubiquitin chains is thus important for hormone-regulated, basic plant architecture.

PubMed ID: 17586653 Exiting the NIEHS site

MeSH Terms: Arabidopsis/drug effects; Arabidopsis/enzymology*; Arabidopsis/genetics; Arabidopsis/growth & development*; Biological Transport/drug effects; Catalysis/drug effects; Cytokinins/metabolism; Enzyme Activation/drug effects; Gene Expression Regulation, Plant/drug effects; Genes, Plant; Indoleacetic Acids/metabolism; Lysine/metabolism*; Membrane Proteins/metabolism; Meristem/drug effects; Mutation/genetics; Myristic Acid/pharmacology; Phenotype; Plant Leaves/cytology; Plant Leaves/drug effects; Plant Shoots/drug effects; Plant Shoots/growth & development*; Protein Transport/drug effects; Recombinant Fusion Proteins/metabolism; Two-Hybrid System Techniques; Ubiquitin-Protein Ligases/metabolism*

Back
to Top