Title: Forging new ties between E. coli genes.
Authors: Ideker, Trey
Published In Cell, (2008 Jun 27)
Abstract: A recent study in Nature (Isalan et al., 2008) has examined the effects of systematically adding new transcriptional interactions in the bacterium Escherichia coli. Surprisingly, the majority of the engineered connections have no effect on growth, and in some cases the new connections enhance fitness. These findings reveal insights into the robustness and evolvability of gene networks.
PubMed ID: 18585345
MeSH Terms: Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Escherichia coli/genetics*; Escherichia coli/growth & development; Escherichia coli/metabolism*; Gene Expression Regulation, Bacterial; Gene Regulatory Networks*; Green Fluorescent Proteins/genetics; Green Fluorescent Proteins/metabolism; Protein Engineering; Transcription Factors/genetics; Transcription Factors/metabolism; Transcription, Genetic