Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Arsenic and cardiovascular disease.

Authors: States, J Christopher; Srivastava, Sanjay; Chen, Yu; Barchowsky, Aaron

Published In Toxicol Sci, (2009 Feb)

Abstract: Chronic arsenic exposure is a worldwide health problem. Although arsenic-induced cancer has been widely studied, comparatively little attention has been paid to arsenic-induced vascular disease. Epidemiological studies have shown that chronic arsenic exposure is associated with increased morbidity and mortality from cardiovascular disease. In addition, studies suggest that susceptibility to arsenic-induced vascular disease may be modified by nutritional factors in addition to genetic factors. Recently, animal models for arsenic-induced atherosclerosis and liver sinusoidal endothelial cell dysfunction have been developed. Initial studies in these models show that arsenic exposure accelerates and exacerbates atherosclerosis in apolipoprotein E-knockout mice. Microarray studies of liver mRNA and micro-RNA abundance in mice exposed in utero suggest that a permanent state of stress is induced by the arsenic exposure. Furthermore, the livers of the arsenic-exposed mice have activated pathways involved in immune responses suggesting a pro-hyperinflammatory state. Arsenic exposure of mice after weaning shows a clear dose-response in the extent of disease exacerbation. In addition, increased inflammation in arterial wall is evident. In response to arsenic-stimulated oxidative signaling, liver sinusoidal endothelium differentiates into a continuous endothelium that limits nutrient exchange and waste elimination. Data suggest that nicotinamide adenine dinucleotide phosphate oxidase-derived superoxide or its derivatives are essential second messengers in the signaling pathway for arsenic-stimulated vessel remodeling. The recent findings provide future directions for research into the cardiovascular effects of arsenic exposure.

PubMed ID: 19015167 Exiting the NIEHS site

MeSH Terms: Animals; Apolipoproteins E/genetics; Arsenic Poisoning/epidemiology; Arsenic Poisoning/genetics; Arsenic Poisoning/pathology*; Arsenic Poisoning/urine; Arsenic/toxicity*; Arsenic/urine; Atherosclerosis/chemically induced; Atherosclerosis/genetics; Atherosclerosis/pathology; Cardiovascular Diseases/epidemiology; Cardiovascular Diseases/genetics; Cardiovascular Diseases/pathology*; Cardiovascular Diseases/urine; Endoplasmic Reticulum/drug effects; Endoplasmic Reticulum/pathology; Environmental Exposure; Hemodynamics/drug effects; Humans; Mice; Mice, Knockout; Oxidative Stress/genetics; Oxidative Stress/physiology; Vasculitis/chemically induced; Vasculitis/genetics; Vasculitis/pathology

to Top