Title: Effects of bisphenol A on adipokine release from human adipose tissue: Implications for the metabolic syndrome.
Authors: Ben-Jonathan, Nira; Hugo, Eric R; Brandebourg, Terry D
Published In Mol Cell Endocrinol, (2009 May 25)
Abstract: Bisphenol A (BPA) is one of the most prevalent and best studied endocrine disruptors. After years of exposure to consumer products containing BPA, most individuals tested have circulating BPA at the low nanomolar levels. In addition to its well documented actions on the reproductive system, BPA exerts a wide variety of metabolic effects. This review summarizes recent findings on the ability of BPA, at environmentally relevant doses, to inhibit adiponectin and stimulate the release of inflammatory adipokines such as interleukin-6 (IL-6) and tumor necrosis factor alpha (TNFalpha) from human adipose tissue. Expression of several classical and non-classical estrogen receptors in human adipose tissue raises the possibility of their involvement as mediators of BPA actions. The implications of these observations to the obesity-related metabolic syndrome and its sequelae are discussed.
PubMed ID: 19433247
MeSH Terms: Adipokines/metabolism*; Adiponectin/metabolism; Adipose Tissue*/drug effects; Adipose Tissue*/metabolism; Air Pollutants, Occupational/chemistry; Air Pollutants, Occupational/metabolism; Air Pollutants, Occupational/pharmacology; Animals; Benzhydryl Compounds; Endocrine Disruptors/chemistry; Endocrine Disruptors/metabolism; Endocrine Disruptors/pharmacology*; Estrogens, Non-Steroidal/chemistry; Estrogens, Non-Steroidal/metabolism; Estrogens, Non-Steroidal/pharmacology; Humans; Interleukin-6/metabolism; Metabolic Syndrome/metabolism*; Molecular Structure; Obesity/metabolism; Phenols/chemistry; Phenols/metabolism; Phenols/pharmacology*; Receptors, Estrogen/metabolism; Tumor Necrosis Factor-alpha/metabolism