Title: The biological functions of NF-kappaB1 (p50) and its potential as an anti-cancer target.
Authors: Yu, Yonghui; Wan, Yu; Huang, Chuanshu
Published In Curr Cancer Drug Targets, (2009 Jun)
Abstract: Nuclear factor-kappaB (NF-kappaB) is a key transcriptional factor family that consists of five members in mammalian cells, including NF-kappaB1 (p50), NF-kappaB2 (p52), RelA (p65), RelB and c-Rel. NF-kappaB is implicated in multiple physiological and pathological processes, including cell proliferation and differentiation, inflammatory and immune response, cell survival and apoptosis, cellular stress reactions and tumorigenesis. Recent studies by our group and others have highlighted the novel functions of the p50 protein. In this review, we will focus on the regulation and functions of NF-kappaB p50.
PubMed ID: 19519322
MeSH Terms: Apoptosis/physiology; Cell Cycle Proteins/biosynthesis; Cell Proliferation; Drug Delivery Systems; Humans; Inflammation/physiopathology; Models, Biological; NF-kappa B p50 Subunit/biosynthesis; NF-kappa B p50 Subunit/physiology*; NF-kappa B p50 Subunit/therapeutic use*; Neoplasms/drug therapy*; Neoplasms/metabolism; Nuclear Proteins/biosynthesis