Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Arsenic exposure predicts bladder cancer survival in a US population.

Authors: Kwong, Ryan C; Karagas, Margaret R; Kelsey, Karl T; Mason, Rebecca A; Tanyos, Sam A; Schned, Alan R; Marsit, Carmen J; Andrew, Angeline S

Published In World J Urol, (2010 Aug)

Abstract: Chronic arsenic exposure at levels found in US drinking water has been associated with bladder cancer. While arsenic is a known carcinogen, recent studies suggest that it is useful as a therapeutic agent for leukemia. This study examined the relationship between arsenic exposure and bladder cancer mortality.We studied 832 cases of bladder cancer diagnosed in New Hampshire from a population-based case-control study. Individual exposure to arsenic was determined in home drinking water using ICP-MS and in toenail samples by instrumental neutron activation analysis.Among the high arsenic exposure group, found using toenail arsenic level or arsenic consumption, cases experienced a de-escalated survival hazard ratio (HR) [high (> or =75 percent) versus low (<25th percentile) toenail arsenic overall survival HR 0.5 (95% CI 0.4-0.8)], controlled for tumor stage, grade, gender, age and treatment regimen. This association was found largely among invasive tumors, in smokers and was not modified by TP53 status. Bladder cancer cause-specific survival showed a similar trend, but did not reach statistical significance [HR 0.5 (95% CI 0.3-1.1)].Arsenic exposure may be related to the survival of patients with bladder cancer.

PubMed ID: 19834714 Exiting the NIEHS site

MeSH Terms: Adult; Aged; Arsenic/analysis*; Case-Control Studies; Environmental Exposure/statistics & numerical data*; Female; Humans; Male; Middle Aged; Nails/chemistry; New Hampshire/epidemiology; Predictive Value of Tests; Risk Factors; Risk Reduction Behavior; Smoking/mortality; Survival Analysis; United States/epidemiology; Urinary Bladder Neoplasms/mortality*; Water Supply/statistics & numerical data*

to Top