Title: Arsenic exposure predicts bladder cancer survival in a US population.
Authors: Kwong, Ryan C; Karagas, Margaret R; Kelsey, Karl T; Mason, Rebecca A; Tanyos, Sam A; Schned, Alan R; Marsit, Carmen J; Andrew, Angeline S
Published In World J Urol, (2010 Aug)
Abstract: Chronic arsenic exposure at levels found in US drinking water has been associated with bladder cancer. While arsenic is a known carcinogen, recent studies suggest that it is useful as a therapeutic agent for leukemia. This study examined the relationship between arsenic exposure and bladder cancer mortality.We studied 832 cases of bladder cancer diagnosed in New Hampshire from a population-based case-control study. Individual exposure to arsenic was determined in home drinking water using ICP-MS and in toenail samples by instrumental neutron activation analysis.Among the high arsenic exposure group, found using toenail arsenic level or arsenic consumption, cases experienced a de-escalated survival hazard ratio (HR) [high (> or =75 percent) versus low (<25th percentile) toenail arsenic overall survival HR 0.5 (95% CI 0.4-0.8)], controlled for tumor stage, grade, gender, age and treatment regimen. This association was found largely among invasive tumors, in smokers and was not modified by TP53 status. Bladder cancer cause-specific survival showed a similar trend, but did not reach statistical significance [HR 0.5 (95% CI 0.3-1.1)].Arsenic exposure may be related to the survival of patients with bladder cancer.
PubMed ID: 19834714
MeSH Terms: Adult; Aged; Arsenic/analysis*; Case-Control Studies; Environmental Exposure/statistics & numerical data*; Female; Humans; Male; Middle Aged; Nails/chemistry; New Hampshire/epidemiology; Predictive Value of Tests; Risk Factors; Risk Reduction Behavior; Smoking/mortality; Survival Analysis; United States/epidemiology; Urinary Bladder Neoplasms/mortality*; Water Supply/statistics & numerical data*