Title: Mechanisms of metal-induced centrosome amplification.
Authors: Holmes, Amie L; Wise, John Pierce
Published In Biochem Soc Trans, (2010 Dec)
Abstract: Exposure to toxic and carcinogenic metals is widespread; however, their mechanisms of action remain largely unknown. One potential mechanism for metal-induced carcinogenicity and toxicity is centrosome amplification. Here we review the mechanisms for metal-induced centrosome amplification, including arsenic, chromium, mercury and nano-titanium dioxide.
PubMed ID: 21118148
MeSH Terms: Animals; Arsenic/toxicity*; Carcinogens/toxicity; Cell Line; Centrosome/drug effects*; Centrosome/metabolism*; Chromium/toxicity*; Environmental Exposure; Humans; Mercury/toxicity*; Nanostructures/toxicity; Titanium/chemistry; Titanium/toxicity*