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Publication Detail

Title: Mechanisms of metal-induced centrosome amplification.

Authors: Holmes, Amie L; Wise, John Pierce

Published In Biochem Soc Trans, (2010 Dec)

Abstract: Exposure to toxic and carcinogenic metals is widespread; however, their mechanisms of action remain largely unknown. One potential mechanism for metal-induced carcinogenicity and toxicity is centrosome amplification. Here we review the mechanisms for metal-induced centrosome amplification, including arsenic, chromium, mercury and nano-titanium dioxide.

PubMed ID: 21118148 Exiting the NIEHS site

MeSH Terms: Animals; Arsenic/toxicity*; Carcinogens/toxicity; Cell Line; Centrosome/drug effects*; Centrosome/metabolism*; Chromium/toxicity*; Environmental Exposure; Humans; Mercury/toxicity*; Nanostructures/toxicity; Titanium/chemistry; Titanium/toxicity*

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