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Publication Detail

Title: Mechanistic basis of resistance to PCBs in Atlantic tomcod from the Hudson River.

Authors: Wirgin, Isaac; Roy, Nirmal K; Loftus, Matthew; Chambers, R Christopher; Franks, Diana G; Hahn, Mark E

Published In Science, (2011 Mar 11)

Abstract: The mechanistic basis of resistance of vertebrate populations to contaminants, including Atlantic tomcod from the Hudson River (HR) to polychlorinated biphenyls (PCBs), is unknown. HR tomcod exhibited variants in the aryl hydrocarbon receptor 2 (AHR2) that were nearly absent elsewhere. In ligand-binding assays, AHR2-1 protein (common in the HR) was impaired as compared to widespread AHR2-2 in binding TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) and in driving expression in reporter gene assays in AHR-deficient cells treated with TCDD or PCB126. We identified a six-base deletion in AHR2 as the basis of resistance and suggest that the HR population has undergone rapid evolution, probably due to contaminant exposure. This mechanistic basis of resistance in a vertebrate population provides evidence of evolutionary change due to selective pressure at a single locus.

PubMed ID: 21330491 Exiting the NIEHS site

MeSH Terms: Animals; Cell Line, Tumor; DNA, Mitochondrial/genetics; Drug Resistance; Evolution, Molecular; Gadiformes/genetics*; Gadiformes/metabolism*; Gene Expression; Gene Frequency; Genes, Reporter; Haplotypes; Ligands; Mice; Molecular Sequence Data; New York; Polychlorinated Biphenyls/metabolism; Polychlorinated Biphenyls/toxicity*; Polychlorinated Dibenzodioxins/metabolism; Polychlorinated Dibenzodioxins/toxicity*; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Receptors, Aryl Hydrocarbon/chemistry; Receptors, Aryl Hydrocarbon/genetics*; Receptors, Aryl Hydrocarbon/metabolism*; Rivers; Selection, Genetic; Sequence Deletion; Water Pollutants, Chemical/metabolism; Water Pollutants, Chemical/toxicity*

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