Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Dietary whey protein lowers the risk for metabolic disease in mice fed a high-fat diet.

Authors: Shertzer, Howard G; Woods, Sally E; Krishan, Mansi; Genter, Mary Beth; Pearson, Kevin J

Published In J Nutr, (2011 Apr 1)

Abstract: Consuming a high-fat (HF) diet produces excessive weight gain, adiposity, and metabolic complications associated with risk for developing type 2 diabetes and fatty liver disease. This study evaluated the influence of whey protein isolate (WPI) on systemic energy balance and metabolic changes in mice fed a HF diet. Female C57BL/6J mice received for 11 wk a HF diet, with or without 100 g WPI/L drinking water. Energy consumption and glucose and lipid metabolism were examined. WPI mice had lower rates of body weight gain and percent body fat and greater lean body mass, although energy consumption was unchanged. These results were consistent with WPI mice having higher basal metabolic rates, respiratory quotients, and hepatic mitochondrial respiration. Health implications for WPI were reflected in early biomarkers for fatty liver disease and type 2 diabetes. Livers from WPI mice had significantly fewer hepatic lipid droplet numbers and less deposition of nonpolar lipids. Furthermore, WPI improved glucose tolerance and insulin sensitivity. We conclude that in mice receiving a HF diet, consumption of WPI results in higher basal metabolic rates and altered metabolism of dietary lipids. Because WPI mice had less hepatosteatosis and insulin resistance, WPI dietary supplements may be effective in slowing the development of fatty liver disease and type 2 diabetes.

PubMed ID: 21310864 Exiting the NIEHS site

MeSH Terms: Animals; Body Composition; Diabetes Mellitus, Type 2/prevention & control*; Dietary Fats/administration & dosage*; Dietary Proteins/administration & dosage*; Energy Metabolism; Fatty Liver/prevention & control*; Female; Humans; Insulin Resistance; Mice; Mice, Inbred C57BL; Milk Proteins/administration & dosage*; Risk

Back
to Top