Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Bioavailability, toxicity, and bioaccumulation of quantum dot nanoparticles to the amphipod Leptocheirus plumulosus.

Authors: Jackson, Brian P; Bugge, Deenie; Ranville, James F; Chen, Celia Y

Published In Environ Sci Technol, (2012 May 15)

Abstract: Understanding the relative toxicities of different modes of nanoparticle exposure as compared with their dissolved metal ions are emerging areas in ecotoxicology. Here, we report on bioavailability, toxicity, and bioaccumulation of carboxyl-functionalized CdSe/ZnS quantum dots (QDs) to the amphipod Leptocheirus plumulosus exposed to equivalent Cd concentrations via dissolved Cd, QDs in water, or QDs in algal food. Both modes of QD exposure were accumulated to greater extent than dissolved Cd. Exposure to QDs via algae resulted in high amphipod mortality. Cadmium and Se in amphipods exposed to QDs in water were highly correlated and spatially localized within the amphipod. In contrast, when exposed to QDs via algae the metals were more disperse and not highly correlated suggesting QD dissolution and resultant metal ion toxicity. This study suggests QDs are accumulated to a greater extent than the dissolved ion and could lead to trophic transfer. QDs ingested with algae are bioavailable and result in toxicity, which is not observed in the absence of algae.

PubMed ID: 22471552 Exiting the NIEHS site

MeSH Terms: Amphipoda/drug effects*; Amphipoda/metabolism*; Animals; Biological Availability; Environmental Exposure/analysis; Metals, Heavy/toxicity; Nanoparticles/toxicity*; Quantum Dots*; Spectrophotometry, Atomic; Survival Analysis

to Top