Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans.

Authors: Myers, Rachel A; Himes, Blanca E; Gignoux, Christopher R; Yang, James J; Gauderman, W James; Rebordosa, Cristina; Xie, Jianming; Torgerson, Dara G; Levin, Albert M; Baurley, James; Graves, Penelope E; Mathias, Rasika A; Romieu, Isabelle; Roth, Lindsey A; Conti, David; Avila, Lydiana; Eng, Celeste; Vora, Hita; LeNoir, Michael A; Soto-Quiros, Manuel; Liu, Jinghua; Celedón, Juan C; Galanter, Joshua M; Farber, Harold J; Kumar, Rajesh; Avila, Pedro C; Meade, Kelley; Serebrisky, Denise; Thyne, Shannon; Rodriguez-Cintron, William; Rodriguez-Santana, Jose R; Borrell, Luisa N; Lemanske Jr, Robert F; Bleecker, Eugene R; Meyers, Deborah A; London, Stephanie J; Barnes, Kathleen C; Raby, Benjamin A; Martinez, Fernando D; Gilliland, Frank D; Williams, L Keoki; Burchard, Esteban G; Weiss, Scott T; Nicolae, Dan L; Ober, Carole

Published In J Allergy Clin Immunol, (2012 Dec)

Abstract: Genome-wide association studies of asthma have implicated many genetic risk factors, with well-replicated associations at approximately 10 loci that account for only a small proportion of the genetic risk.We aimed to identify additional asthma risk loci by performing an extensive replication study of the results from the EVE Consortium meta-analysis.We selected 3186 single nucleotide polymorphisms for replication based on the P values from the EVE Consortium meta-analysis. These single nucleotide polymorphisms were genotyped in ethnically diverse replication samples from 9 different studies, totaling 7202 cases, 6426 controls, and 507 case-parent trios. Association analyses were conducted within each participating study, and the resulting test statistics were combined in a meta-analysis.Two novel associations were replicated in European Americans: rs1061477 in the KLK3 gene on chromosome 19 (combined odds ratio = 1.18; 95% CI, 1.10-1.25) and rs9570077 (combined odds ratio =1.20; 95% CI, 1.12-1.29) on chromosome 13q21. We could not replicate any additional associations in the African Americans or Latinos.This extended replication study identified 2 additional asthma risk loci in populations of European descent. The absence of additional loci for African Americans and Latinos highlights the difficulty in replicating associations in admixed populations.

PubMed ID: 23040885 Exiting the NIEHS site

MeSH Terms: African Americans; Asthma/epidemiology*; Asthma/genetics*; Asthma/immunology; Chromosomes, Human, Pair 19/genetics*; DNA Mutational Analysis; European Continental Ancestry Group; Genetic Loci/immunology; Genetic Predisposition to Disease; Genome-Wide Association Study; Hispanic Americans; Humans; Kallikreins/genetics*; Meta-Analysis as Topic; Polymorphism, Single Nucleotide; Prostate-Specific Antigen/genetics*; Risk Factors; United States

Back
to Top