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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer.

Authors: Zhang, Guodong; Kodani, Sean; Hammock, Bruce D

Published In Prog Lipid Res, (2014 Jan)

Abstract: Epoxygenated fatty acids (EpFAs), which are lipid mediators produced by cytochrome P450 epoxygenases from polyunsaturated fatty acids, are important signaling molecules known to regulate various biological processes including inflammation, pain and angiogenesis. The EpFAs are further metabolized by soluble epoxide hydrolase (sEH) to form fatty acid diols which are usually less-active. Pharmacological inhibitors of sEH that stabilize endogenous EpFAs are being considered for human clinical uses. Here we review the biology of ω-3 and ω-6 EpFAs on inflammation, pain, angiogenesis and tumorigenesis.

PubMed ID: 24345640 Exiting the NIEHS site

MeSH Terms: Animals; Fatty Acids/chemistry; Fatty Acids/metabolism*; Humans; Inflammation/metabolism; Neoplasms/metabolism*; Neovascularization, Pathologic/metabolism*; Pain/metabolism*

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