Title: Molecular responses to hypoxia-inducible factor 1α and beyond.
Authors: Brocato, Jason; Chervona, Yana; Costa, Max
Published In Mol Pharmacol, (2014 May)
Abstract: Cellular response to changes in oxygen tension during normal development or pathologic processes is, in part, regulated by hypoxia-inducible factor (HIF), an oxygen-sensitive transcription factor. HIF activity is primarily controlled through post-translational modifications and stabilization of HIF-1α and HIF-2α proteins and is regulated by a number of cellular pathways involving both oxygen-dependent and -independent mechanisms. Stabilization of HIF-1α activates transcription of genes that participate in key pathways in carcinogenesis, such as angiogenesis, dedifferentiation, and invasion. Since its discovery more than two decades ago, HIF-1α has become a hot topic in molecular research and has been implicated not only in disease pathology but also in prognosis. In this review, we will focus on recent insights into HIF-1α regulation, function, and gene expression. We will also discuss emerging data on the involvement of HIF in cancer prognosis and therapeutic interventions.
PubMed ID: 24569087
MeSH Terms: Animals; Cell Hypoxia/physiology; Humans; Hypoxia-Inducible Factor 1, alpha Subunit/genetics*; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism*; Neoplasms/diagnosis; Neoplasms/genetics; Neoplasms/metabolism; Neovascularization, Pathologic/diagnosis; Neovascularization, Pathologic/genetics; Neovascularization, Pathologic/metabolism; Transcription Factors/genetics; Transcription Factors/metabolism