Title: Prenatal exposure to air toxics and risk of Wilms' tumor in 0- to 5-year-old children.
Authors: Shrestha, Anshu; Ritz, Beate; Wilhelm, Michelle; Qiu, Jiaheng; Cockburn, Myles; Heck, Julia E
Published In J Occup Environ Med, (2014 Jun)
Abstract: To study prenatal air toxic exposure and Wilms' tumor in children.We identified 337 Wilms' tumor cases among children younger than 6 years (1988 to 2008) from the California Cancer Registry, randomly selected 96,514 controls from California birth rolls in 20:1 ratio matched to all cancer cases, then linked birth addresses to air monitors within 15 miles to assess exposures. Multiple logistic regressions were applied to estimate effects.Children prenatally exposed to formaldehyde, polycyclic aromatic hydrocarbons, perchloroethylene, or acetaldehyde in the third trimester had an increased odds of Wilms' tumor per interquartile increase in concentration (odds ratio [95% confidence interval]: 1.28 [1.12 to 1.45], 1.10 [0.99 to 1.22], 1.09 [1.00 to 1.18], 1.25 [1.07 to 1.45], respectively).We found positive associations for four air toxics. This is the first study of this kind. Future studies are needed to confirm our findings.
PubMed ID: 24854250
MeSH Terms: Air Pollutants; California/epidemiology; Child, Preschool; Female; Formaldehyde; Humans; Infant; Infant, Newborn; Kidney Neoplasms/epidemiology*; Logistic Models; Male; Polycyclic Aromatic Hydrocarbons; Pregnancy; Pregnancy Trimester, Third; Prenatal Exposure Delayed Effects*/epidemiology; Wilms Tumor/epidemiology*