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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Association between chlorinated pesticides in the serum of prepubertal Russian boys and longitudinal biomarkers of metabolic function.

Authors: Burns, Jane S; Williams, Paige L; Korrick, Susan A; Hauser, Russ; Sergeyev, Oleg; Revich, Boris; Lam, Thuy; Lee, Mary M

Published In Am J Epidemiol, (2014 Nov 01)

Abstract: Organochlorine pesticides (OCPs) have been linked to adult metabolic disorders; however, few studies have examined these associations in childhood. We prospectively evaluated the associations of baseline serum OCPs (hexachlorobenzene, β-hexachlorocyclohexane, and p,p'-dichlorodiphenyldichloroethylene) in Russian boys with subsequent repeated measurements of serum glucose, insulin, lipids, leptin, and calculated homeostatic model assessment of insulin resistance (IR). During 2003-2005, we enrolled 499 boys aged 8-9 years in a prospective cohort; 318 had baseline serum OCPs and serum biomarkers measured at ages 10-13 years. Multivariable generalized estimating equation and mediation regression models were used to examine associations and direct and indirect (via body mass index (BMI) (weight (kg)/height (m)(2))) effects of prepubertal OCP tertiles and quintiles with biomarkers. In multivariable models, higher p,p'-dichlorodiphenyldichloroethylene (quintile 5 vs. quintile 1) was associated with lower leptin, with relative mean decreases of 61.8% (95% confidence interval: 48.4%, 71.7%) in models unadjusted for BMI and 22.2% (95% confidence interval: 7.1%, 34.9%) in models adjusted for BMI; the direct effect of p,p'-dichlorodiphenyldichloroethylene on leptin accounted for 27% of the total effect. IR prevalence was 6.6% at ages 12-13 years. Higher hexachlorobenzene (tertile 3 vs. tertile 1) was associated with higher odds of IR in models adjusted for BMI (odds ratio = 4.37, 95% confidence interval: 1.44, 13.28). These results suggest that childhood OCPs may be associated with IR and lower leptin.

PubMed ID: 25255811 Exiting the NIEHS site

MeSH Terms: Adolescent; Biomarkers/blood; Blood Glucose/analysis; Child; Cholesterol/blood; Humans; Hydrocarbons, Chlorinated/blood*; Insulin Resistance*; Insulin/blood; Leptin/blood; Male; Metabolic Syndrome/blood*; Pesticides/blood*; Prospective Studies; Regression Analysis; Triglycerides/blood

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